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Parkinsonian signs and substantia nigra neuron density in decendents elders without PD.
Ann Neurol. 2004 Oct; 56(4):532-9.AN

Abstract

Substantia nigra (SN) neurons were counted on single, transverse caudal midbrain sections from 217 male participants in the Honolulu-Asia Aging Study, aged 74-97 years at death. Quadrants areas within the SN were determined with a planimeter and neuronal density was expressed as neurons/mm(2) for 10 Parkinson's disease (PD) cases, 29 incidental Lewy body cases, and 178 controls with neither condition. Mean densities in all quadrants were significantly lower in the PD group compared with the other groups (p = 0.006). This relationship was strongest in the ventrolateral quadrant. In a subgroup of 50 controls who were examined with the Unified Parkinson's Disease Rating Scale an average of 2.1 years prior to death, there was an association of stooped posture (p = 0.009), postural instability (p = 0.013), body bradykinesia (p = 0.048), and gait disturbance (p = 0.05) with neuron density in the dorsolateral quadrant; and impaired speech (p = 0.014), abnormal facial expression (p = 0.022), and difficulty rising from a chair (p = 0.032) with neuron density in the dorsomedial quadrant. There was a significant association of increasing number of signs present with decreasing neuron density in both quadrants (p = 0.001 for trend). Low SN neuron density may be the basis for parkinsonian signs in the elderly without PD.

Authors+Show Affiliations

Honolulu Department of Veteran's Affairs, Honolulu, HI, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15389895

Citation

Ross, G Webster, et al. "Parkinsonian Signs and Substantia Nigra Neuron Density in Decendents Elders Without PD." Annals of Neurology, vol. 56, no. 4, 2004, pp. 532-9.
Ross GW, Petrovitch H, Abbott RD, et al. Parkinsonian signs and substantia nigra neuron density in decendents elders without PD. Ann Neurol. 2004;56(4):532-9.
Ross, G. W., Petrovitch, H., Abbott, R. D., Nelson, J., Markesbery, W., Davis, D., Hardman, J., Launer, L., Masaki, K., Tanner, C. M., & White, L. R. (2004). Parkinsonian signs and substantia nigra neuron density in decendents elders without PD. Annals of Neurology, 56(4), 532-9.
Ross GW, et al. Parkinsonian Signs and Substantia Nigra Neuron Density in Decendents Elders Without PD. Ann Neurol. 2004;56(4):532-9. PubMed PMID: 15389895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinsonian signs and substantia nigra neuron density in decendents elders without PD. AU - Ross,G Webster, AU - Petrovitch,Helen, AU - Abbott,Robert D, AU - Nelson,James, AU - Markesbery,William, AU - Davis,Daron, AU - Hardman,John, AU - Launer,Lenore, AU - Masaki,Kamal, AU - Tanner,Caroline M, AU - White,Lon R, PY - 2004/9/25/pubmed PY - 2004/12/16/medline PY - 2004/9/25/entrez SP - 532 EP - 9 JF - Annals of neurology JO - Ann Neurol VL - 56 IS - 4 N2 - Substantia nigra (SN) neurons were counted on single, transverse caudal midbrain sections from 217 male participants in the Honolulu-Asia Aging Study, aged 74-97 years at death. Quadrants areas within the SN were determined with a planimeter and neuronal density was expressed as neurons/mm(2) for 10 Parkinson's disease (PD) cases, 29 incidental Lewy body cases, and 178 controls with neither condition. Mean densities in all quadrants were significantly lower in the PD group compared with the other groups (p = 0.006). This relationship was strongest in the ventrolateral quadrant. In a subgroup of 50 controls who were examined with the Unified Parkinson's Disease Rating Scale an average of 2.1 years prior to death, there was an association of stooped posture (p = 0.009), postural instability (p = 0.013), body bradykinesia (p = 0.048), and gait disturbance (p = 0.05) with neuron density in the dorsolateral quadrant; and impaired speech (p = 0.014), abnormal facial expression (p = 0.022), and difficulty rising from a chair (p = 0.032) with neuron density in the dorsomedial quadrant. There was a significant association of increasing number of signs present with decreasing neuron density in both quadrants (p = 0.001 for trend). Low SN neuron density may be the basis for parkinsonian signs in the elderly without PD. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/15389895/Parkinsonian_signs_and_substantia_nigra_neuron_density_in_decendents_elders_without_PD_ L2 - https://doi.org/10.1002/ana.20226 DB - PRIME DP - Unbound Medicine ER -