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Comparative cognitive effects of bilateral subthalamic stimulation and subcutaneous continuous infusion of apomorphine in Parkinson's disease.
Mov Disord. 2004 Dec; 19(12):1463-9.MD

Abstract

Bilateral subthalamic deep brain stimulation (STN-DBS) and continuous subcutaneous infusion of apomorphine (APM-csi) can provide a comparable improvement on motor function in patients with advanced Parkinson's disease (PD), but the mechanisms by which both therapies exert their effects are different. We analyzed the cognitive effects of APM-csi. We also compared neuropsychological effects induced by STN-DBS and APM-csi in advanced PD to ascertain the neuropsychological aspects relevant in determining the therapeutic procedure that is the most appropriate in a particular patient. We studied 9 patients treated with STN-DBS and 7 patients with APM-csi. Neuropsychological measures included Rey's Auditory-Verbal Learning, Stroop, Trail Making, phonetic verbal fluency, and Judgment of Line Orientation tests. In the APM-csi group, significant changes were not observed in the neuropsychological tests performance. By contrast, in the STN-DBS group, moderate worsening was found in phonetic verbal fluency and Stroop Naming scores that was partially reversible at long-term follow-up and did not have consequences on regular activities. Consequently, these findings could be interpreted as being not relevant in deciding the most suitable treatment in a given patient.

Authors+Show Affiliations

Parkinson's Disease and Movement Disorders Unit, Service of Neurology, Institut de Malalties del Sistema Nerviós, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15390065

Citation

Alegret, Montse, et al. "Comparative Cognitive Effects of Bilateral Subthalamic Stimulation and Subcutaneous Continuous Infusion of Apomorphine in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 19, no. 12, 2004, pp. 1463-9.
Alegret M, Valldeoriola F, Martí M, et al. Comparative cognitive effects of bilateral subthalamic stimulation and subcutaneous continuous infusion of apomorphine in Parkinson's disease. Mov Disord. 2004;19(12):1463-9.
Alegret, M., Valldeoriola, F., Martí, M., Pilleri, M., Junqué, C., Rumià, J., & Tolosa, E. (2004). Comparative cognitive effects of bilateral subthalamic stimulation and subcutaneous continuous infusion of apomorphine in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 19(12), 1463-9.
Alegret M, et al. Comparative Cognitive Effects of Bilateral Subthalamic Stimulation and Subcutaneous Continuous Infusion of Apomorphine in Parkinson's Disease. Mov Disord. 2004;19(12):1463-9. PubMed PMID: 15390065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative cognitive effects of bilateral subthalamic stimulation and subcutaneous continuous infusion of apomorphine in Parkinson's disease. AU - Alegret,Montse, AU - Valldeoriola,Francesc, AU - Martí,MaJosé, AU - Pilleri,Manuela, AU - Junqué,Carme, AU - Rumià,Jordi, AU - Tolosa,Eduardo, PY - 2004/9/25/pubmed PY - 2005/4/9/medline PY - 2004/9/25/entrez SP - 1463 EP - 9 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 19 IS - 12 N2 - Bilateral subthalamic deep brain stimulation (STN-DBS) and continuous subcutaneous infusion of apomorphine (APM-csi) can provide a comparable improvement on motor function in patients with advanced Parkinson's disease (PD), but the mechanisms by which both therapies exert their effects are different. We analyzed the cognitive effects of APM-csi. We also compared neuropsychological effects induced by STN-DBS and APM-csi in advanced PD to ascertain the neuropsychological aspects relevant in determining the therapeutic procedure that is the most appropriate in a particular patient. We studied 9 patients treated with STN-DBS and 7 patients with APM-csi. Neuropsychological measures included Rey's Auditory-Verbal Learning, Stroop, Trail Making, phonetic verbal fluency, and Judgment of Line Orientation tests. In the APM-csi group, significant changes were not observed in the neuropsychological tests performance. By contrast, in the STN-DBS group, moderate worsening was found in phonetic verbal fluency and Stroop Naming scores that was partially reversible at long-term follow-up and did not have consequences on regular activities. Consequently, these findings could be interpreted as being not relevant in deciding the most suitable treatment in a given patient. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/15390065/Comparative_cognitive_effects_of_bilateral_subthalamic_stimulation_and_subcutaneous_continuous_infusion_of_apomorphine_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.20237 DB - PRIME DP - Unbound Medicine ER -