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[Determination of vitamin b12 deficiency].
Ugeskr Laeger. 1992 Feb 03; 154(6):323-5.UL

Abstract

Development of cobalamin deficiency in the tissues is considered to be a process which lasts for years. Macrocytic anaemia and/or neurological symptoms do not occur until late in this process. Serum cobalamins as the only parameter have proved less suitable for differentiation between healthy individuals with low serum cobalamin values and patients who require cobalamin for the remainder of their lives. The need for a better indicator for cobalamin deficiency has been emphasized. Recently developed methods of measurement have rendered determinations of serum methylmalonic acid possible. This value is raised in cases of cobalamin deficiency in the tissues. The serum methylmalonic values have proved both sensitive and specific to determine the extent to which genuine cobalamin deficiency is present or not and may also be employed for monitoring the effect of treatment as the raised values becomes normalized following substitution therapy with vitamin B12.

Authors+Show Affiliations

Aalborg Sygehus, medicinsk haematologisk afdeling og klinisk kemisk afdeling.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

dan

PubMed ID

1539360

Citation

Mølby, L, et al. "[Determination of Vitamin B12 Deficiency]." Ugeskrift for Laeger, vol. 154, no. 6, 1992, pp. 323-5.
Mølby L, Rasmussen K, Jensen MK, et al. [Determination of vitamin b12 deficiency]. Ugeskr Laeger. 1992;154(6):323-5.
Mølby, L., Rasmussen, K., Jensen, M. K., & Pedersen, K. O. (1992). [Determination of vitamin b12 deficiency]. Ugeskrift for Laeger, 154(6), 323-5.
Mølby L, et al. [Determination of Vitamin B12 Deficiency]. Ugeskr Laeger. 1992 Feb 3;154(6):323-5. PubMed PMID: 1539360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Determination of vitamin b12 deficiency]. AU - Mølby,L, AU - Rasmussen,K, AU - Jensen,M K, AU - Pedersen,K O, PY - 1992/2/3/pubmed PY - 1992/2/3/medline PY - 1992/2/3/entrez SP - 323 EP - 5 JF - Ugeskrift for laeger JO - Ugeskr Laeger VL - 154 IS - 6 N2 - Development of cobalamin deficiency in the tissues is considered to be a process which lasts for years. Macrocytic anaemia and/or neurological symptoms do not occur until late in this process. Serum cobalamins as the only parameter have proved less suitable for differentiation between healthy individuals with low serum cobalamin values and patients who require cobalamin for the remainder of their lives. The need for a better indicator for cobalamin deficiency has been emphasized. Recently developed methods of measurement have rendered determinations of serum methylmalonic acid possible. This value is raised in cases of cobalamin deficiency in the tissues. The serum methylmalonic values have proved both sensitive and specific to determine the extent to which genuine cobalamin deficiency is present or not and may also be employed for monitoring the effect of treatment as the raised values becomes normalized following substitution therapy with vitamin B12. SN - 0041-5782 UR - https://www.unboundmedicine.com/medline/citation/1539360/[Determination_of_vitamin_b12_deficiency]_ DB - PRIME DP - Unbound Medicine ER -
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