[Cobalamin deficiency despite normal serum cobalamins].
Ugeskr Laeger. 1992 Feb 03; 154(6):346-7.UL

Abstract

In a man aged 77 years with normal concentrations of cobalamins in the serum, the concentration of methylmalonic acid in the serum was raised (2,920 nmol/l; 50-370 nmol/l). (The serum cobalamin concentrations were measured both by an old R-binder method (400 pmol/l; reference interval 200-800 pmol/l) and by a more recent S-binder method (164 pmol/l; 95-585 pmol/l)). Following a saturation dose of vitamin B12, the serum concentration of methylmalonic acid became normal (215 nmol/l) indicating that the patient had had functional cobalamin deficiency. The clinician should never let himself be deceived by a normal concentration of cobalamins in the serum and thus discard a suspicion of cobalamin deficiency. Measurement of serum methyl-malonic acid, which is a sensitive and specific analysis to differentiate between the presence or absence of cobalamin deficiency, is recommended to elucidate cases of doubt.

Authors+Show Affiliations

Rasmussen K

Arhus Kommunehospital, klinisk-kemisk afdeling.

Pedersen KO

No affiliation info available

Sillesen S

No affiliation info available

MeSH

AgedChemistry, ClinicalHumansMaleMethylmalonic AcidVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Case Reports

English Abstract

Journal Article

Language

dan

PubMed ID

1539366

Citation

Rasmussen, K, et al. "[Cobalamin Deficiency Despite Normal Serum Cobalamins]." Ugeskrift for Laeger, vol. 154, no. 6, 1992, pp. 346-7.

Rasmussen K, Pedersen KO, Sillesen S. [Cobalamin deficiency despite normal serum cobalamins]. Ugeskr Laeger. 1992;154(6):346-7.

Rasmussen, K., Pedersen, K. O., & Sillesen, S. (1992). [Cobalamin deficiency despite normal serum cobalamins]. Ugeskrift for Laeger, 154(6), 346-7.

Rasmussen K, Pedersen KO, Sillesen S. [Cobalamin Deficiency Despite Normal Serum Cobalamins]. Ugeskr Laeger. 1992 Feb 3;154(6):346-7. PubMed PMID: 1539366.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - [Cobalamin deficiency despite normal serum cobalamins]. AU - Rasmussen,K, AU - Pedersen,K O, AU - Sillesen,S, PY - 1992/2/3/pubmed PY - 1992/2/3/medline PY - 1992/2/3/entrez SP - 346 EP - 7 JF - Ugeskrift for laeger JO - Ugeskr Laeger VL - 154 IS - 6 N2 - In a man aged 77 years with normal concentrations of cobalamins in the serum, the concentration of methylmalonic acid in the serum was raised (2,920 nmol/l; 50-370 nmol/l). (The serum cobalamin concentrations were measured both by an old R-binder method (400 pmol/l; reference interval 200-800 pmol/l) and by a more recent S-binder method (164 pmol/l; 95-585 pmol/l)). Following a saturation dose of vitamin B12, the serum concentration of methylmalonic acid became normal (215 nmol/l) indicating that the patient had had functional cobalamin deficiency. The clinician should never let himself be deceived by a normal concentration of cobalamins in the serum and thus discard a suspicion of cobalamin deficiency. Measurement of serum methyl-malonic acid, which is a sensitive and specific analysis to differentiate between the presence or absence of cobalamin deficiency, is recommended to elucidate cases of doubt. SN - 0041-5782 UR - https://www.unboundmedicine.com/medline/citation/1539366/[Cobalamin_deficiency_despite_normal_serum_cobalamins]_ DB - PRIME DP - Unbound Medicine ER -

Tags

[Cobalamin deficiency despite normal serum cobalamins].Ugeskr Laeger. 1992 Feb 03; 154(6):346-7.UL