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The restless legs syndrome and periodic limb movement disorder: a review of management.
Semin Neurol. 2004 Sep; 24(3):249-59.SN

Abstract

The restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) are distinguishable but overlapping disorders. Both feature nocturnal involuntary limb movements (periodic limb movements) that can cause sleep disruption, but each has distinct clinical features that are relevant to the diagnosis and management of the patient. The diagnosis of RLS is made by meeting established clinical criteria, not from discovery of periodic limb movements of sleep (PLMS) on a sleep study. PLMD, however, does require the presence of PLMS on polysomnography as well as an associated sleep complaint. Moreover, PLMS are themselves nonspecific, occurring both with RLS and with other sleep disorders as well as in normal individuals. The diagnosis of PLMD, then, requires not merely finding a significant number of PLMS but also excluding other potential causes for the associated sleep complaint. Treatment of RLS is based on consideration of the pattern and severity of the disorder, with dopaminergic drugs generally favored for initial treatment. Anticonvulsants, opioids, and sedative/hypnotics also have a role. A treatment algorithm is provided to assist with the management of RLS. Treatment of PLMD relies on many of the same medications, but is generally more straightforward and places a greater reliance on levodopa compounds and sedative-hypnotics.

Authors+Show Affiliations

RLS Center, Department of Neurology, Johns Hopkins Medical School, Baltimore, Maryland, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15449218

Citation

Lesage, Suzanne, and Wayne A. Hening. "The Restless Legs Syndrome and Periodic Limb Movement Disorder: a Review of Management." Seminars in Neurology, vol. 24, no. 3, 2004, pp. 249-59.
Lesage S, Hening WA. The restless legs syndrome and periodic limb movement disorder: a review of management. Semin Neurol. 2004;24(3):249-59.
Lesage, S., & Hening, W. A. (2004). The restless legs syndrome and periodic limb movement disorder: a review of management. Seminars in Neurology, 24(3), 249-59.
Lesage S, Hening WA. The Restless Legs Syndrome and Periodic Limb Movement Disorder: a Review of Management. Semin Neurol. 2004;24(3):249-59. PubMed PMID: 15449218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The restless legs syndrome and periodic limb movement disorder: a review of management. AU - Lesage,Suzanne, AU - Hening,Wayne A, PY - 2004/9/28/pubmed PY - 2004/12/16/medline PY - 2004/9/28/entrez SP - 249 EP - 59 JF - Seminars in neurology JO - Semin Neurol VL - 24 IS - 3 N2 - The restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) are distinguishable but overlapping disorders. Both feature nocturnal involuntary limb movements (periodic limb movements) that can cause sleep disruption, but each has distinct clinical features that are relevant to the diagnosis and management of the patient. The diagnosis of RLS is made by meeting established clinical criteria, not from discovery of periodic limb movements of sleep (PLMS) on a sleep study. PLMD, however, does require the presence of PLMS on polysomnography as well as an associated sleep complaint. Moreover, PLMS are themselves nonspecific, occurring both with RLS and with other sleep disorders as well as in normal individuals. The diagnosis of PLMD, then, requires not merely finding a significant number of PLMS but also excluding other potential causes for the associated sleep complaint. Treatment of RLS is based on consideration of the pattern and severity of the disorder, with dopaminergic drugs generally favored for initial treatment. Anticonvulsants, opioids, and sedative/hypnotics also have a role. A treatment algorithm is provided to assist with the management of RLS. Treatment of PLMD relies on many of the same medications, but is generally more straightforward and places a greater reliance on levodopa compounds and sedative-hypnotics. SN - 0271-8235 UR - https://www.unboundmedicine.com/medline/citation/15449218/The_restless_legs_syndrome_and_periodic_limb_movement_disorder:_a_review_of_management_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-835066 DB - PRIME DP - Unbound Medicine ER -