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Human soleus muscle protein synthesis following resistance exercise.
Acta Physiol Scand. 2004 Oct; 182(2):189-96.AP

Abstract

AIM

It is generally believed the calf muscles in humans are relatively unresponsive to resistance training when compared with other muscles of the body. The purpose of this investigation was to determine the muscle protein synthesis response of the soleus muscle following a standard high intensity bout of resistance exercise.

METHODS

Eight recreationally active males (27 +/- 4 years) completed three unilateral calf muscle exercises: standing calf press/heel raise, bent-knee calf press/heel raise, and seated calf press/heel raise. Each exercise consisted of four sets of 15 repetitions (approximately 15 repetition maximum, RM, or approximately 70% 1RM). Fractional rate of muscle protein synthesis (FSR) was determined with a primed constant infusion of [2H5]phenylalanine coupled with muscle biopsies immediately and 3 h following the exercise in both the exercise and non-exercise (resting control) leg.

RESULTS

FSR was elevated (P < 0.05) in the exercise (0.069 +/- 0.010) vs. the control (0.051 +/- 0.012) leg. Muscle glycogen concentration was lower (P < 0.05) in the exercise compared with the control leg (Decrease from control; immediate post-exercise: 54 +/- 5; 3 h post-exercise: 36 +/- 4 mmol kg(-1) wet wt.). This relatively high amount of glycogen use is comparable with previous studies of resistance exercise of the thigh (i.e. vastus lateralis; approximately 41-49 mmol kg(-1) wet wt.). However, the exercise-induced increase in FSR that has been consistently reported for the vastus lateralis (approximately 0.045-0.060% h(-1)) is on average approximately 200% higher than reported here for the soleus (0.019 +/- 0.003% h(-1)).

CONCLUSIONS

These results suggest the relatively poor response of soleus muscle protein synthesis to an acute bout of resistance exercise may be the basis for the relative inability of the calf muscles to respond to resistance training programs.

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Authors+Show Affiliations

Trappe TA
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Raue U
No affiliation info available
Tesch PA
No affiliation info available

MeSH

AdultElectromyographyExerciseGlycogenHumansLegMaleMuscle ProteinsMuscle, SkeletalPhenylalanine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15450115

Citation

Trappe, T A., et al. "Human Soleus Muscle Protein Synthesis Following Resistance Exercise." Acta Physiologica Scandinavica, vol. 182, no. 2, 2004, pp. 189-96.
Trappe TA, Raue U, Tesch PA. Human soleus muscle protein synthesis following resistance exercise. Acta Physiol Scand. 2004;182(2):189-96.
Trappe, T. A., Raue, U., & Tesch, P. A. (2004). Human soleus muscle protein synthesis following resistance exercise. Acta Physiologica Scandinavica, 182(2), 189-96.
Trappe TA, Raue U, Tesch PA. Human Soleus Muscle Protein Synthesis Following Resistance Exercise. Acta Physiol Scand. 2004;182(2):189-96. PubMed PMID: 15450115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human soleus muscle protein synthesis following resistance exercise. AU - Trappe,T A, AU - Raue,U, AU - Tesch,P A, PY - 2004/9/29/pubmed PY - 2005/1/26/medline PY - 2004/9/29/entrez SP - 189 EP - 96 JF - Acta physiologica Scandinavica JO - Acta Physiol Scand VL - 182 IS - 2 N2 - AIM: It is generally believed the calf muscles in humans are relatively unresponsive to resistance training when compared with other muscles of the body. The purpose of this investigation was to determine the muscle protein synthesis response of the soleus muscle following a standard high intensity bout of resistance exercise. METHODS: Eight recreationally active males (27 +/- 4 years) completed three unilateral calf muscle exercises: standing calf press/heel raise, bent-knee calf press/heel raise, and seated calf press/heel raise. Each exercise consisted of four sets of 15 repetitions (approximately 15 repetition maximum, RM, or approximately 70% 1RM). Fractional rate of muscle protein synthesis (FSR) was determined with a primed constant infusion of [2H5]phenylalanine coupled with muscle biopsies immediately and 3 h following the exercise in both the exercise and non-exercise (resting control) leg. RESULTS: FSR was elevated (P < 0.05) in the exercise (0.069 +/- 0.010) vs. the control (0.051 +/- 0.012) leg. Muscle glycogen concentration was lower (P < 0.05) in the exercise compared with the control leg (Decrease from control; immediate post-exercise: 54 +/- 5; 3 h post-exercise: 36 +/- 4 mmol kg(-1) wet wt.). This relatively high amount of glycogen use is comparable with previous studies of resistance exercise of the thigh (i.e. vastus lateralis; approximately 41-49 mmol kg(-1) wet wt.). However, the exercise-induced increase in FSR that has been consistently reported for the vastus lateralis (approximately 0.045-0.060% h(-1)) is on average approximately 200% higher than reported here for the soleus (0.019 +/- 0.003% h(-1)). CONCLUSIONS: These results suggest the relatively poor response of soleus muscle protein synthesis to an acute bout of resistance exercise may be the basis for the relative inability of the calf muscles to respond to resistance training programs. SN - 0001-6772 UR - https://www.unboundmedicine.com/medline/citation/15450115/Human_soleus_muscle_protein_synthesis_following_resistance_exercise_ L2 - https://doi.org/10.1111/j.1365-201X.2004.01348.x DB - PRIME DP - Unbound Medicine ER -