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[The stability of solid food labeled with different radiopharmaceuticals for studying gastric emptying].
Rev Esp Med Nucl. 2004 Sep-Oct; 23(5):343-6.RE

Abstract

OBJECTIVE

Sulfur colloid 99mTc-SC, the radiopharmaceutical of choice for solid gastric emptying studies, is not available in our country. It has led us to assess the solid binding stability of seven alternative radiopharmaceuticals that could present adequate fixation to it a priori.

MATERIALS AND METHOD

The stability of labelled solid food with seven colloidal 99mTc-radiopharmaceuticals of different sizes and nature (MAA, tin colloid, rhenium sulphide macrocolloid, albumin microcolloid, sulfur nanocolloid, albumin nanocolloid and rhenium sulfur nanocolloid) has been studied by measuring their dissociated activity after two hours digestion in simulated gastric fluid (kept 120' in agitation, in HCl 0.1 M at 37). The survey also assesses radiopharmaceutical labelling stability after two hours digestion in identical conditions by measuring their radiochemical purity in ITLC.

RESULTS

In these conditions, MAA, rhenium sulphide macrocolloid, albumin microcolloid and albumin microcolloid present the best behaviour, with an activity linked to food over 90 % of the previously fixed activity.

CONCLUSIONS

According to the results, there is no relationship between the radiopharmaceutical size and nature and the stability of its binding to the solid food. Because rhenium sulphide macrocolloid is no longer manufactured and the other three radiopharmaceuticals which have a binding stability to the solid food over 90 % do not include digestive explorations amongst their indications, nowadays, there is a serious legal limitation to carry out this type of studies in our country.

Authors+Show Affiliations

Unidad de Radiofarmacia, Servicio de Medicina Nuclear, Hospital Universitario Virgen de la Arrixaca, Murcia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

spa

PubMed ID

15450140

Citation

Martínez, T, et al. "[The Stability of Solid Food Labeled With Different Radiopharmaceuticals for Studying Gastric Emptying]." Revista Espanola De Medicina Nuclear, vol. 23, no. 5, 2004, pp. 343-6.
Martínez T, Benítez D, Nuño de la Rosa JA, et al. [The stability of solid food labeled with different radiopharmaceuticals for studying gastric emptying]. Rev Esp Med Nucl. 2004;23(5):343-6.
Martínez, T., Benítez, D., Nuño de la Rosa, J. A., & Fuente, T. (2004). [The stability of solid food labeled with different radiopharmaceuticals for studying gastric emptying]. Revista Espanola De Medicina Nuclear, 23(5), 343-6.
Martínez T, et al. [The Stability of Solid Food Labeled With Different Radiopharmaceuticals for Studying Gastric Emptying]. Rev Esp Med Nucl. 2004 Sep-Oct;23(5):343-6. PubMed PMID: 15450140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The stability of solid food labeled with different radiopharmaceuticals for studying gastric emptying]. AU - Martínez,T, AU - Benítez,D, AU - Nuño de la Rosa,J A, AU - Fuente,T, PY - 2004/9/29/pubmed PY - 2005/2/5/medline PY - 2004/9/29/entrez SP - 343 EP - 6 JF - Revista espanola de medicina nuclear JO - Rev Esp Med Nucl VL - 23 IS - 5 N2 - OBJECTIVE: Sulfur colloid 99mTc-SC, the radiopharmaceutical of choice for solid gastric emptying studies, is not available in our country. It has led us to assess the solid binding stability of seven alternative radiopharmaceuticals that could present adequate fixation to it a priori. MATERIALS AND METHOD: The stability of labelled solid food with seven colloidal 99mTc-radiopharmaceuticals of different sizes and nature (MAA, tin colloid, rhenium sulphide macrocolloid, albumin microcolloid, sulfur nanocolloid, albumin nanocolloid and rhenium sulfur nanocolloid) has been studied by measuring their dissociated activity after two hours digestion in simulated gastric fluid (kept 120' in agitation, in HCl 0.1 M at 37). The survey also assesses radiopharmaceutical labelling stability after two hours digestion in identical conditions by measuring their radiochemical purity in ITLC. RESULTS: In these conditions, MAA, rhenium sulphide macrocolloid, albumin microcolloid and albumin microcolloid present the best behaviour, with an activity linked to food over 90 % of the previously fixed activity. CONCLUSIONS: According to the results, there is no relationship between the radiopharmaceutical size and nature and the stability of its binding to the solid food. Because rhenium sulphide macrocolloid is no longer manufactured and the other three radiopharmaceuticals which have a binding stability to the solid food over 90 % do not include digestive explorations amongst their indications, nowadays, there is a serious legal limitation to carry out this type of studies in our country. SN - 0212-6982 UR - https://www.unboundmedicine.com/medline/citation/15450140/[The_stability_of_solid_food_labeled_with_different_radiopharmaceuticals_for_studying_gastric_emptying]_ DB - PRIME DP - Unbound Medicine ER -