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Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis.
Clin Immunol. 2004 Nov; 113(2):140-4.CI

Abstract

Interferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-gamma, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-alpha concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi.

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Authors+Show Affiliations

Chierakul W
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
de Fost M
No affiliation info available
Suputtamongkol Y
No affiliation info available
Limpaiboon R
No affiliation info available
Dondorp A
No affiliation info available
White NJ
No affiliation info available
van der Poll T
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overAnimalsFemaleHumansInterferon-gammaInterleukin-15Interleukin-18Leptospira interrogansLeptospirosisMaleMiddle AgedOrientia tsutsugamushiScrub TyphusThailandTumor Necrosis Factor-alpha

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15451469

Citation

Chierakul, Wirongrong, et al. "Differential Expression of Interferon-gamma and Interferon-gamma-inducing Cytokines in Thai Patients With Scrub Typhus or Leptospirosis." Clinical Immunology (Orlando, Fla.), vol. 113, no. 2, 2004, pp. 140-4.
Chierakul W, de Fost M, Suputtamongkol Y, et al. Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. Clin Immunol. 2004;113(2):140-4.
Chierakul, W., de Fost, M., Suputtamongkol, Y., Limpaiboon, R., Dondorp, A., White, N. J., & van der Poll, T. (2004). Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. Clinical Immunology (Orlando, Fla.), 113(2), 140-4.
Chierakul W, et al. Differential Expression of Interferon-gamma and Interferon-gamma-inducing Cytokines in Thai Patients With Scrub Typhus or Leptospirosis. Clin Immunol. 2004;113(2):140-4. PubMed PMID: 15451469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. AU - Chierakul,Wirongrong, AU - de Fost,Maaike, AU - Suputtamongkol,Yupin, AU - Limpaiboon,Roongreung, AU - Dondorp,Arjen, AU - White,Nicholas J, AU - van der Poll,Tom, PY - 2004/04/16/received PY - 2004/08/09/accepted PY - 2004/9/29/pubmed PY - 2004/12/16/medline PY - 2004/9/29/entrez SP - 140 EP - 4 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 113 IS - 2 N2 - Interferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-gamma, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-alpha concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi. SN - 1521-6616 UR - https://www.unboundmedicine.com/medline/citation/15451469/Differential_expression_of_interferon_gamma_and_interferon_gamma_inducing_cytokines_in_Thai_patients_with_scrub_typhus_or_leptospirosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(04)00248-7 DB - PRIME DP - Unbound Medicine ER -