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Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis.
Clin Immunol. 2004 Nov; 113(2):140-4.CI

Abstract

Interferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-gamma, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-alpha concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi.

Authors+Show Affiliations

Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15451469

Citation

Chierakul, Wirongrong, et al. "Differential Expression of Interferon-gamma and Interferon-gamma-inducing Cytokines in Thai Patients With Scrub Typhus or Leptospirosis." Clinical Immunology (Orlando, Fla.), vol. 113, no. 2, 2004, pp. 140-4.
Chierakul W, de Fost M, Suputtamongkol Y, et al. Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. Clin Immunol. 2004;113(2):140-4.
Chierakul, W., de Fost, M., Suputtamongkol, Y., Limpaiboon, R., Dondorp, A., White, N. J., & van der Poll, T. (2004). Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. Clinical Immunology (Orlando, Fla.), 113(2), 140-4.
Chierakul W, et al. Differential Expression of Interferon-gamma and Interferon-gamma-inducing Cytokines in Thai Patients With Scrub Typhus or Leptospirosis. Clin Immunol. 2004;113(2):140-4. PubMed PMID: 15451469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. AU - Chierakul,Wirongrong, AU - de Fost,Maaike, AU - Suputtamongkol,Yupin, AU - Limpaiboon,Roongreung, AU - Dondorp,Arjen, AU - White,Nicholas J, AU - van der Poll,Tom, PY - 2004/04/16/received PY - 2004/08/09/accepted PY - 2004/9/29/pubmed PY - 2004/12/16/medline PY - 2004/9/29/entrez SP - 140 EP - 4 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 113 IS - 2 N2 - Interferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-gamma, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-alpha concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi. SN - 1521-6616 UR - https://www.unboundmedicine.com/medline/citation/15451469/Differential_expression_of_interferon_gamma_and_interferon_gamma_inducing_cytokines_in_Thai_patients_with_scrub_typhus_or_leptospirosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(04)00248-7 DB - PRIME DP - Unbound Medicine ER -