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Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug.
Eur J Pharm Biopharm. 2004 Nov; 58(3):697-703.EJ

Abstract

The objective of the present study is to carry out pharmacokinetic evaluation of oral controlled release formulation (guar gum-based three-layer matrix tablets) containing highly soluble metoprolol tartrate as a model drug. Six healthy volunteers participated in the study, and a two-way crossover design was followed. The plasma concentration of metoprolol tartrate was estimated by reverse-phase HPLC. The pharmacokinetic parameters were calculated from the plasma concentration of metoprolol tartrate versus time data. The delayed T(max) lower C(max) decreased K(a) unaltered bioavailability and prolonged t(1/2) indicated a slow and prolonged release of metoprolol tartrate from guar gum three-layer matrix tablets in comparison with the immediate release tablet dosage form. The results of the study indicated that guar gum three-layer matrix tablets were able to provide oral controlled delivery of highly water-soluble drug such as metoprolol tartrate in humans.

Authors+Show Affiliations

Al-Saidan SM
Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, SAFAT, Kuwait.
Krishnaiah YS
No affiliation info available
Satyanarayana V
No affiliation info available
Bhaskar P
No affiliation info available
Karthikeyan RS
No affiliation info available

MeSH

Administration, OralAdultAnalysis of VarianceChemistry, PharmaceuticalCross-Over StudiesDelayed-Action PreparationsDrug EvaluationGalactansHumansMaleMannansMetoprololModels, ChemicalPlant GumsSolubilityTablets, Enteric-Coated

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15451547

Citation

Al-Saidan, S M., et al. "Pharmacokinetic Evaluation of Guar Gum-based Three-layer Matrix Tablets for Oral Controlled Delivery of Highly Soluble Metoprolol Tartrate as a Model Drug." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 58, no. 3, 2004, pp. 697-703.
Al-Saidan SM, Krishnaiah YS, Satyanarayana V, et al. Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug. Eur J Pharm Biopharm. 2004;58(3):697-703.
Al-Saidan, S. M., Krishnaiah, Y. S., Satyanarayana, V., Bhaskar, P., & Karthikeyan, R. S. (2004). Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 58(3), 697-703.
Al-Saidan SM, et al. Pharmacokinetic Evaluation of Guar Gum-based Three-layer Matrix Tablets for Oral Controlled Delivery of Highly Soluble Metoprolol Tartrate as a Model Drug. Eur J Pharm Biopharm. 2004;58(3):697-703. PubMed PMID: 15451547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug. AU - Al-Saidan,S M, AU - Krishnaiah,Y S R, AU - Satyanarayana,V, AU - Bhaskar,P, AU - Karthikeyan,R S, PY - 2003/10/27/received PY - 2004/04/05/revised PY - 2004/04/25/accepted PY - 2004/9/29/pubmed PY - 2005/3/16/medline PY - 2004/9/29/entrez SP - 697 EP - 703 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 58 IS - 3 N2 - The objective of the present study is to carry out pharmacokinetic evaluation of oral controlled release formulation (guar gum-based three-layer matrix tablets) containing highly soluble metoprolol tartrate as a model drug. Six healthy volunteers participated in the study, and a two-way crossover design was followed. The plasma concentration of metoprolol tartrate was estimated by reverse-phase HPLC. The pharmacokinetic parameters were calculated from the plasma concentration of metoprolol tartrate versus time data. The delayed T(max) lower C(max) decreased K(a) unaltered bioavailability and prolonged t(1/2) indicated a slow and prolonged release of metoprolol tartrate from guar gum three-layer matrix tablets in comparison with the immediate release tablet dosage form. The results of the study indicated that guar gum three-layer matrix tablets were able to provide oral controlled delivery of highly water-soluble drug such as metoprolol tartrate in humans. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/15451547/Pharmacokinetic_evaluation_of_guar_gum_based_three_layer_matrix_tablets_for_oral_controlled_delivery_of_highly_soluble_metoprolol_tartrate_as_a_model_drug_ DB - PRIME DP - Unbound Medicine ER -