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Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug.
Eur J Pharm Biopharm. 2004 Nov; 58(3):697-703.EJ

Abstract

The objective of the present study is to carry out pharmacokinetic evaluation of oral controlled release formulation (guar gum-based three-layer matrix tablets) containing highly soluble metoprolol tartrate as a model drug. Six healthy volunteers participated in the study, and a two-way crossover design was followed. The plasma concentration of metoprolol tartrate was estimated by reverse-phase HPLC. The pharmacokinetic parameters were calculated from the plasma concentration of metoprolol tartrate versus time data. The delayed T(max) lower C(max) decreased K(a) unaltered bioavailability and prolonged t(1/2) indicated a slow and prolonged release of metoprolol tartrate from guar gum three-layer matrix tablets in comparison with the immediate release tablet dosage form. The results of the study indicated that guar gum three-layer matrix tablets were able to provide oral controlled delivery of highly water-soluble drug such as metoprolol tartrate in humans.

Authors+Show Affiliations

Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, SAFAT, Kuwait.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15451547

Citation

Al-Saidan, S M., et al. "Pharmacokinetic Evaluation of Guar Gum-based Three-layer Matrix Tablets for Oral Controlled Delivery of Highly Soluble Metoprolol Tartrate as a Model Drug." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 58, no. 3, 2004, pp. 697-703.
Al-Saidan SM, Krishnaiah YS, Satyanarayana V, et al. Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug. Eur J Pharm Biopharm. 2004;58(3):697-703.
Al-Saidan, S. M., Krishnaiah, Y. S., Satyanarayana, V., Bhaskar, P., & Karthikeyan, R. S. (2004). Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 58(3), 697-703.
Al-Saidan SM, et al. Pharmacokinetic Evaluation of Guar Gum-based Three-layer Matrix Tablets for Oral Controlled Delivery of Highly Soluble Metoprolol Tartrate as a Model Drug. Eur J Pharm Biopharm. 2004;58(3):697-703. PubMed PMID: 15451547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug. AU - Al-Saidan,S M, AU - Krishnaiah,Y S R, AU - Satyanarayana,V, AU - Bhaskar,P, AU - Karthikeyan,R S, PY - 2003/10/27/received PY - 2004/04/05/revised PY - 2004/04/25/accepted PY - 2004/9/29/pubmed PY - 2005/3/16/medline PY - 2004/9/29/entrez SP - 697 EP - 703 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 58 IS - 3 N2 - The objective of the present study is to carry out pharmacokinetic evaluation of oral controlled release formulation (guar gum-based three-layer matrix tablets) containing highly soluble metoprolol tartrate as a model drug. Six healthy volunteers participated in the study, and a two-way crossover design was followed. The plasma concentration of metoprolol tartrate was estimated by reverse-phase HPLC. The pharmacokinetic parameters were calculated from the plasma concentration of metoprolol tartrate versus time data. The delayed T(max) lower C(max) decreased K(a) unaltered bioavailability and prolonged t(1/2) indicated a slow and prolonged release of metoprolol tartrate from guar gum three-layer matrix tablets in comparison with the immediate release tablet dosage form. The results of the study indicated that guar gum three-layer matrix tablets were able to provide oral controlled delivery of highly water-soluble drug such as metoprolol tartrate in humans. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/15451547/Pharmacokinetic_evaluation_of_guar_gum_based_three_layer_matrix_tablets_for_oral_controlled_delivery_of_highly_soluble_metoprolol_tartrate_as_a_model_drug_ DB - PRIME DP - Unbound Medicine ER -