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[Assessment of urinary beta-core fragment of hCG as a tumor marker of cervical cancer].
Nihon Sanka Fujinka Gakkai Zasshi. 1992 Feb; 44(2):188-94.NS

Abstract

Beta-core fragment (beta-CF), a fragment of the hCG beta-subunit missing its carboxyterminal peptide, can be detected in the urine of women throughout pregnancy or in trophoblastic disease. It is also found in the urine of patients with nontrophoblastic cancers. We examined the beta-CF level in urine samples from patients with cervical cancer and assessed its value as a tumor marker. beta-CF was measured by an enzyme immunoassay with hCG beta-core directed monoclonal antibody No. 229. Based on the cut-off value (0.2ng/ml) from control subjects, the overall positivity rate for urinary beta-CF in the cervical cancer group was 45% (57 of 128 patients), increasing from 32% (23 of 73) in stage I to 100% (2 of 2) in stage IV. These positivity rates exceeded or equaled those of the other markers, SCC, CEA, CA19-9 and CA125, simultaneously measured in the patients' serum. There was no significant difference between the positivity rates for the two histological types of cancer, squamous cell carcinoma and adenocarcinoma. Serial determination in 28 patients with increased urinary beta-CF prior to therapy showed that 24 patients had a decreased concentration after successful treatment, but 2 of 4 patients with still increased urinary beta-CF during or after treatment subsequently relapsed. The determination of urinary beta-CF may provide a useful tool in monitoring the response to treatment in patients with cervical cancer.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Hyogo Medical Center for Adults.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

jpn

PubMed ID

1545171

Citation

Kinugasa, M, et al. "[Assessment of Urinary Beta-core Fragment of hCG as a Tumor Marker of Cervical Cancer]." Nihon Sanka Fujinka Gakkai Zasshi, vol. 44, no. 2, 1992, pp. 188-94.
Kinugasa M, Nishimura R, Hasegawa K, et al. [Assessment of urinary beta-core fragment of hCG as a tumor marker of cervical cancer]. Nihon Sanka Fujinka Gakkai Zasshi. 1992;44(2):188-94.
Kinugasa, M., Nishimura, R., Hasegawa, K., Okamura, M., Kimura, A., Ohtsu, F., & Takeuchi, K. (1992). [Assessment of urinary beta-core fragment of hCG as a tumor marker of cervical cancer]. Nihon Sanka Fujinka Gakkai Zasshi, 44(2), 188-94.
Kinugasa M, et al. [Assessment of Urinary Beta-core Fragment of hCG as a Tumor Marker of Cervical Cancer]. Nihon Sanka Fujinka Gakkai Zasshi. 1992;44(2):188-94. PubMed PMID: 1545171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Assessment of urinary beta-core fragment of hCG as a tumor marker of cervical cancer]. AU - Kinugasa,M, AU - Nishimura,R, AU - Hasegawa,K, AU - Okamura,M, AU - Kimura,A, AU - Ohtsu,F, AU - Takeuchi,K, PY - 1992/2/1/pubmed PY - 1992/2/1/medline PY - 1992/2/1/entrez SP - 188 EP - 94 JF - Nihon Sanka Fujinka Gakkai zasshi JO - Nihon Sanka Fujinka Gakkai Zasshi VL - 44 IS - 2 N2 - Beta-core fragment (beta-CF), a fragment of the hCG beta-subunit missing its carboxyterminal peptide, can be detected in the urine of women throughout pregnancy or in trophoblastic disease. It is also found in the urine of patients with nontrophoblastic cancers. We examined the beta-CF level in urine samples from patients with cervical cancer and assessed its value as a tumor marker. beta-CF was measured by an enzyme immunoassay with hCG beta-core directed monoclonal antibody No. 229. Based on the cut-off value (0.2ng/ml) from control subjects, the overall positivity rate for urinary beta-CF in the cervical cancer group was 45% (57 of 128 patients), increasing from 32% (23 of 73) in stage I to 100% (2 of 2) in stage IV. These positivity rates exceeded or equaled those of the other markers, SCC, CEA, CA19-9 and CA125, simultaneously measured in the patients' serum. There was no significant difference between the positivity rates for the two histological types of cancer, squamous cell carcinoma and adenocarcinoma. Serial determination in 28 patients with increased urinary beta-CF prior to therapy showed that 24 patients had a decreased concentration after successful treatment, but 2 of 4 patients with still increased urinary beta-CF during or after treatment subsequently relapsed. The determination of urinary beta-CF may provide a useful tool in monitoring the response to treatment in patients with cervical cancer. SN - 0300-9165 UR - https://www.unboundmedicine.com/medline/citation/1545171/[Assessment_of_urinary_beta_core_fragment_of_hCG_as_a_tumor_marker_of_cervical_cancer]_ L2 - https://www.diseaseinfosearch.org/result/7949 DB - PRIME DP - Unbound Medicine ER -