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Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver.
J Biochem Mol Toxicol. 2004; 18(4):234-8.JB

Abstract

The aim of this study was to examine the effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation (LPO) and the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in the liver of streptozotocin (STZ)-induced diabetic rats. Twenty-seven rats were randomly divided into three groups: group I, control non-diabetic rats (n = 9); group II, STZ-induced, untreated diabetic rats (n = 8); group III, STZ-induced, CAPE-treated diabetic rats (n = 10), which were intraperitoneally injected with CAPE (10 microM kg(-1) day(-1)) after 3 days followed by STZ treatment. The liver was excised after 8 weeks of CAPE treatment, the levels of malondialdehyde (MDA) and the activities of SOD, CAT, and GSH-Px in the hepatic tissues of all groups were analyzed. In the untreated diabetic rats, MDA markedly increased in the hepatic tissue compared with the control rats (p < 0.0001). However, MDA levels were reduced to the control level by CAPE. The activities of SOD, CAT, and GSH-Px in the untreated diabetic group were higher than that in the control group (p < 0.0001). The activities of SOD and GSH-Px in the CAPE-treated diabetic group were higher than that in the control group (respectively, p < 0.0001, p < 0.035). There were no significant differences in the activity of CAT between the rats of CAPE-treated diabetic and control groups. Rats in the CAPE-treated diabetic group had reduced activities of SOD and CAT in comparison with the rats of untreated diabetic group (p < 0.0001). There were no significant differences in the activity of GSH-Px between the rats of untreated diabetic and CAPE-treated groups. It is likely that STZ-induced diabetes caused liver damage. In addition, LPO may be one of the molecular mechanisms involved in STZ-induced diabetic damage. CAPE can reduce LPO caused by STZ-induced diabetes.

Authors+Show Affiliations

Department of Medical Biology and Genetics, Suleyman Demirel University, Faculty of Medicine, and Isparta, Turkey. hramazany@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15452882

Citation

Yilmaz, H Ramazan, et al. "Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) On Lipid Peroxidation and Antioxidant Enzymes in Diabetic Rat Liver." Journal of Biochemical and Molecular Toxicology, vol. 18, no. 4, 2004, pp. 234-8.
Yilmaz HR, Uz E, Yucel N, et al. Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver. J Biochem Mol Toxicol. 2004;18(4):234-8.
Yilmaz, H. R., Uz, E., Yucel, N., Altuntas, I., & Ozcelik, N. (2004). Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver. Journal of Biochemical and Molecular Toxicology, 18(4), 234-8.
Yilmaz HR, et al. Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) On Lipid Peroxidation and Antioxidant Enzymes in Diabetic Rat Liver. J Biochem Mol Toxicol. 2004;18(4):234-8. PubMed PMID: 15452882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation and antioxidant enzymes in diabetic rat liver. AU - Yilmaz,H Ramazan, AU - Uz,Efkan, AU - Yucel,Nezahat, AU - Altuntas,Irfan, AU - Ozcelik,Nurten, PY - 2004/9/29/pubmed PY - 2005/2/17/medline PY - 2004/9/29/entrez SP - 234 EP - 8 JF - Journal of biochemical and molecular toxicology JO - J Biochem Mol Toxicol VL - 18 IS - 4 N2 - The aim of this study was to examine the effect of caffeic acid phenethyl ester (CAPE) on lipid peroxidation (LPO) and the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in the liver of streptozotocin (STZ)-induced diabetic rats. Twenty-seven rats were randomly divided into three groups: group I, control non-diabetic rats (n = 9); group II, STZ-induced, untreated diabetic rats (n = 8); group III, STZ-induced, CAPE-treated diabetic rats (n = 10), which were intraperitoneally injected with CAPE (10 microM kg(-1) day(-1)) after 3 days followed by STZ treatment. The liver was excised after 8 weeks of CAPE treatment, the levels of malondialdehyde (MDA) and the activities of SOD, CAT, and GSH-Px in the hepatic tissues of all groups were analyzed. In the untreated diabetic rats, MDA markedly increased in the hepatic tissue compared with the control rats (p < 0.0001). However, MDA levels were reduced to the control level by CAPE. The activities of SOD, CAT, and GSH-Px in the untreated diabetic group were higher than that in the control group (p < 0.0001). The activities of SOD and GSH-Px in the CAPE-treated diabetic group were higher than that in the control group (respectively, p < 0.0001, p < 0.035). There were no significant differences in the activity of CAT between the rats of CAPE-treated diabetic and control groups. Rats in the CAPE-treated diabetic group had reduced activities of SOD and CAT in comparison with the rats of untreated diabetic group (p < 0.0001). There were no significant differences in the activity of GSH-Px between the rats of untreated diabetic and CAPE-treated groups. It is likely that STZ-induced diabetes caused liver damage. In addition, LPO may be one of the molecular mechanisms involved in STZ-induced diabetic damage. CAPE can reduce LPO caused by STZ-induced diabetes. SN - 1095-6670 UR - https://www.unboundmedicine.com/medline/citation/15452882/Protective_effect_of_caffeic_acid_phenethyl_ester__CAPE__on_lipid_peroxidation_and_antioxidant_enzymes_in_diabetic_rat_liver_ L2 - https://doi.org/10.1002/jbt.20028 DB - PRIME DP - Unbound Medicine ER -