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A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59.
Genetics. 2004 Sep; 168(1):553-7.G

Abstract

We isolated a novel rad52 mutation, rad52-L89F, which specifically impairs recombination in rad51Delta cells. rad52-L89F displays phenotypes similar to rad59Delta and encodes a mutant protein impaired in its ability to interact with Rad59. These results support the idea that Rad59 acts in homologous recombination via physical interaction with Rad52.

Authors+Show Affiliations

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15454565

Citation

Cortés-Ledesma, Felipe, et al. "A Novel Yeast Mutation, rad52-L89F, Causes a Specific Defect in Rad51-independent Recombination That Correlates With a Reduced Ability of Rad52-L89F to Interact With Rad59." Genetics, vol. 168, no. 1, 2004, pp. 553-7.
Cortés-Ledesma F, Malagón F, Aguilera A. A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59. Genetics. 2004;168(1):553-7.
Cortés-Ledesma, F., Malagón, F., & Aguilera, A. (2004). A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59. Genetics, 168(1), 553-7.
Cortés-Ledesma F, Malagón F, Aguilera A. A Novel Yeast Mutation, rad52-L89F, Causes a Specific Defect in Rad51-independent Recombination That Correlates With a Reduced Ability of Rad52-L89F to Interact With Rad59. Genetics. 2004;168(1):553-7. PubMed PMID: 15454565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59. AU - Cortés-Ledesma,Felipe, AU - Malagón,Francisco, AU - Aguilera,Andrés, PY - 2004/9/30/pubmed PY - 2005/4/13/medline PY - 2004/9/30/entrez SP - 553 EP - 7 JF - Genetics JO - Genetics VL - 168 IS - 1 N2 - We isolated a novel rad52 mutation, rad52-L89F, which specifically impairs recombination in rad51Delta cells. rad52-L89F displays phenotypes similar to rad59Delta and encodes a mutant protein impaired in its ability to interact with Rad59. These results support the idea that Rad59 acts in homologous recombination via physical interaction with Rad52. SN - 0016-6731 UR - https://www.unboundmedicine.com/medline/citation/15454565/A_novel_yeast_mutation_rad52_L89F_causes_a_specific_defect_in_Rad51_independent_recombination_that_correlates_with_a_reduced_ability_of_Rad52_L89F_to_interact_with_Rad59_ L2 - https://academic.oup.com/genetics/article-lookup/doi/10.1534/genetics.104.030551 DB - PRIME DP - Unbound Medicine ER -