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A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59.
Genetics. 2004 Sep; 168(1):553-7.G

Abstract

We isolated a novel rad52 mutation, rad52-L89F, which specifically impairs recombination in rad51Delta cells. rad52-L89F displays phenotypes similar to rad59Delta and encodes a mutant protein impaired in its ability to interact with Rad59. These results support the idea that Rad59 acts in homologous recombination via physical interaction with Rad52.

Links

Publisher Full Text
ncbi.nlm.nih.gov
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Authors+Show Affiliations

Cortés-Ledesma F
Departamento de Genética, Facultad de Biología, Universidad de Sevilla, 41012, Spain.
Malagón F
No affiliation info available
Aguilera A
No affiliation info available

MeSH

Amino Acid SequenceDNA-Binding ProteinsElectrophoresis, Polyacrylamide GelMethyl MethanesulfonateMolecular Sequence DataMutationRad51 RecombinaseRad52 DNA Repair and Recombination ProteinRecombination, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Alignment

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15454565

Citation

Cortés-Ledesma, Felipe, et al. "A Novel Yeast Mutation, rad52-L89F, Causes a Specific Defect in Rad51-independent Recombination That Correlates With a Reduced Ability of Rad52-L89F to Interact With Rad59." Genetics, vol. 168, no. 1, 2004, pp. 553-7.
Cortés-Ledesma F, Malagón F, Aguilera A. A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59. Genetics. 2004;168(1):553-7.
Cortés-Ledesma, F., Malagón, F., & Aguilera, A. (2004). A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59. Genetics, 168(1), 553-7.
Cortés-Ledesma F, Malagón F, Aguilera A. A Novel Yeast Mutation, rad52-L89F, Causes a Specific Defect in Rad51-independent Recombination That Correlates With a Reduced Ability of Rad52-L89F to Interact With Rad59. Genetics. 2004;168(1):553-7. PubMed PMID: 15454565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59. AU - Cortés-Ledesma,Felipe, AU - Malagón,Francisco, AU - Aguilera,Andrés, PY - 2004/9/30/pubmed PY - 2005/4/13/medline PY - 2004/9/30/entrez SP - 553 EP - 7 JF - Genetics JO - Genetics VL - 168 IS - 1 N2 - We isolated a novel rad52 mutation, rad52-L89F, which specifically impairs recombination in rad51Delta cells. rad52-L89F displays phenotypes similar to rad59Delta and encodes a mutant protein impaired in its ability to interact with Rad59. These results support the idea that Rad59 acts in homologous recombination via physical interaction with Rad52. SN - 0016-6731 UR - https://www.unboundmedicine.com/medline/citation/15454565/A_novel_yeast_mutation_rad52_L89F_causes_a_specific_defect_in_Rad51_independent_recombination_that_correlates_with_a_reduced_ability_of_Rad52_L89F_to_interact_with_Rad59_ L2 - https://academic.oup.com/genetics/article-lookup/doi/10.1534/genetics.104.030551 DB - PRIME DP - Unbound Medicine ER -