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Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women.

Abstract

OBJECTIVE

To examine the feasibility of using phylloquinone intake as a marker for coronary heart disease (CHD) and stroke risk in women.

DESIGN AND SETTING

Nurses' Health Study, a prospective cohort study during 1984-2000. Dietary data were collected in 1984, 1986, 1990, and 1994 using a validated semiquantitative food frequency questionnaire.

SUBJECTS

A total of 72 874 female nurses, aged 38-65 y, without previously diagnosed angina, myocardial infarction (MI), stroke, or cancer at baseline.

MAIN OUTCOME MEASURES

Incidence of nonfatal MI, CHD deaths, total CHD events, ischemic, and total strokes.

RESULTS

There were 1679 CHD events (1201 nonfatal) and 1009 strokes (567 ischemic). After adjustment for age and lifestyle factors associated with cardiovascular disease risk, the multivariate relative risks (RR) (95% CI) of total CHD from the lowest to the highest quintile category of phylloquinone intake were 1 (reference), 0.80 (0.69-0.94), 0.86 (0.74-1.00), 0.77 (0.66-0.99), and 0.79 (0.68-0.92), P for trend=0.01. Further adjustment for dietary intakes of saturated fat, polyunsaturated fat, trans fatty acids, eicosapentaenoic, and docosahexaenoic acids, cereal fiber, and folate attenuated the association (RR comparing extreme quintiles 0.84 [0.71-1.00], P for trend=0.12). Incidence rates of total or ischemic strokes were not associated with phylloquinone intake.

CONCLUSION

The data suggest that high phylloquinone intake may be a marker for low CHD risk. Dietary and lifestyle patterns associated with phylloquinone intakes, rather than intake of the nutrient itself, might account for all or part of the weak association. .

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  • Authors+Show Affiliations

    ,

    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. arja.erkkila@uku.fi

    , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Biomarkers
    Cohort Studies
    Coronary Disease
    Diet
    Dietary Fats
    Dietary Fiber
    Female
    Folic Acid
    Follow-Up Studies
    Humans
    Incidence
    Life Style
    Middle Aged
    Nutrition Surveys
    Prospective Studies
    Risk
    Stroke
    Surveys and Questionnaires
    Vitamin K 1

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15454972

    Citation

    Erkkilä, A T., et al. "Phylloquinone Intake as a Marker for Coronary Heart Disease Risk but Not Stroke in Women." European Journal of Clinical Nutrition, vol. 59, no. 2, 2005, pp. 196-204.
    Erkkilä AT, Booth SL, Hu FB, et al. Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women. Eur J Clin Nutr. 2005;59(2):196-204.
    Erkkilä, A. T., Booth, S. L., Hu, F. B., Jacques, P. F., Manson, J. E., Rexrode, K. M., ... Lichtenstein, A. H. (2005). Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women. European Journal of Clinical Nutrition, 59(2), pp. 196-204.
    Erkkilä AT, et al. Phylloquinone Intake as a Marker for Coronary Heart Disease Risk but Not Stroke in Women. Eur J Clin Nutr. 2005;59(2):196-204. PubMed PMID: 15454972.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Phylloquinone intake as a marker for coronary heart disease risk but not stroke in women. AU - Erkkilä,A T, AU - Booth,S L, AU - Hu,F B, AU - Jacques,P F, AU - Manson,J E, AU - Rexrode,K M, AU - Stampfer,M J, AU - Lichtenstein,A H, PY - 2004/9/30/pubmed PY - 2005/5/6/medline PY - 2004/9/30/entrez SP - 196 EP - 204 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 2 N2 - OBJECTIVE: To examine the feasibility of using phylloquinone intake as a marker for coronary heart disease (CHD) and stroke risk in women. DESIGN AND SETTING: Nurses' Health Study, a prospective cohort study during 1984-2000. Dietary data were collected in 1984, 1986, 1990, and 1994 using a validated semiquantitative food frequency questionnaire. SUBJECTS: A total of 72 874 female nurses, aged 38-65 y, without previously diagnosed angina, myocardial infarction (MI), stroke, or cancer at baseline. MAIN OUTCOME MEASURES: Incidence of nonfatal MI, CHD deaths, total CHD events, ischemic, and total strokes. RESULTS: There were 1679 CHD events (1201 nonfatal) and 1009 strokes (567 ischemic). After adjustment for age and lifestyle factors associated with cardiovascular disease risk, the multivariate relative risks (RR) (95% CI) of total CHD from the lowest to the highest quintile category of phylloquinone intake were 1 (reference), 0.80 (0.69-0.94), 0.86 (0.74-1.00), 0.77 (0.66-0.99), and 0.79 (0.68-0.92), P for trend=0.01. Further adjustment for dietary intakes of saturated fat, polyunsaturated fat, trans fatty acids, eicosapentaenoic, and docosahexaenoic acids, cereal fiber, and folate attenuated the association (RR comparing extreme quintiles 0.84 [0.71-1.00], P for trend=0.12). Incidence rates of total or ischemic strokes were not associated with phylloquinone intake. CONCLUSION: The data suggest that high phylloquinone intake may be a marker for low CHD risk. Dietary and lifestyle patterns associated with phylloquinone intakes, rather than intake of the nutrient itself, might account for all or part of the weak association. . SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15454972/Phylloquinone_intake_as_a_marker_for_coronary_heart_disease_risk_but_not_stroke_in_women_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602058 DB - PRIME DP - Unbound Medicine ER -