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Effects of melatonin on acute necrotizing pancreatitis in rats.
Z Gastroenterol. 2004 Sep; 42(9):967-72.ZG

Abstract

The aim of this study was to investigate the influence of melatonin on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. The induction of ANP resulted in significant increases in mortality rate, pancreatic necrosis and increased serum activity of amylase, alanine aspartate transferase (ALT), interleukin 6 (IL-6), lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid, serum concentration of urea, tissue activity of myeloperoxidase (MPO) and malondialdehyde (MDA) in the pancreas and lung, and significant decrease of concentrations of calcium, blood pressure, urine output and pO (2). Melatonin inhibited the changes in blood pressure, urine output, pO (2), serum concentration of urea, and calcium, tissue activity of MPO and MDA in the pancreas and lung, LDH level in BAL fluid, and partially reduced serum activity of IL-6. Melatonin did not change serum activity of amylase, ALT, pancreatic damage and the mortality rate. The use of melatonin has a limited value on the course of ANP. It may be useful as a supportive treatment during ANP.

Authors+Show Affiliations

Alhan E
Department of Surgery, Karadeniz Technical University, Trabzon, Turkey. alhan@meds.ktu.edu
Kalyoncu NI
No affiliation info available
Kural BV
No affiliation info available
Erçin C
No affiliation info available

MeSH

AnimalsAntioxidantsClinical Enzyme TestsData Interpretation, StatisticalDisease Models, AnimalFree Radical ScavengersFree RadicalsHemodynamicsLipid PeroxidationMaleMelatoninMultiple Organ FailurePancreasPancreatitis, Acute NecrotizingRatsRats, Sprague-DawleyTime Factors

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

15455265

Citation

Alhan, E, et al. "Effects of Melatonin On Acute Necrotizing Pancreatitis in Rats." Zeitschrift Fur Gastroenterologie, vol. 42, no. 9, 2004, pp. 967-72.
Alhan E, Kalyoncu NI, Kural BV, et al. Effects of melatonin on acute necrotizing pancreatitis in rats. Z Gastroenterol. 2004;42(9):967-72.
Alhan, E., Kalyoncu, N. I., Kural, B. V., & Erçin, C. (2004). Effects of melatonin on acute necrotizing pancreatitis in rats. Zeitschrift Fur Gastroenterologie, 42(9), 967-72.
Alhan E, et al. Effects of Melatonin On Acute Necrotizing Pancreatitis in Rats. Z Gastroenterol. 2004;42(9):967-72. PubMed PMID: 15455265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of melatonin on acute necrotizing pancreatitis in rats. AU - Alhan,E, AU - Kalyoncu,N I, AU - Kural,B V, AU - Erçin,C, PY - 2004/9/30/pubmed PY - 2004/12/21/medline PY - 2004/9/30/entrez SP - 967 EP - 72 JF - Zeitschrift fur Gastroenterologie JO - Z Gastroenterol VL - 42 IS - 9 N2 - The aim of this study was to investigate the influence of melatonin on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. The induction of ANP resulted in significant increases in mortality rate, pancreatic necrosis and increased serum activity of amylase, alanine aspartate transferase (ALT), interleukin 6 (IL-6), lactate dehydrogenase (LDH) in bronchoalveolar lavage (BAL) fluid, serum concentration of urea, tissue activity of myeloperoxidase (MPO) and malondialdehyde (MDA) in the pancreas and lung, and significant decrease of concentrations of calcium, blood pressure, urine output and pO (2). Melatonin inhibited the changes in blood pressure, urine output, pO (2), serum concentration of urea, and calcium, tissue activity of MPO and MDA in the pancreas and lung, LDH level in BAL fluid, and partially reduced serum activity of IL-6. Melatonin did not change serum activity of amylase, ALT, pancreatic damage and the mortality rate. The use of melatonin has a limited value on the course of ANP. It may be useful as a supportive treatment during ANP. SN - 0044-2771 UR - https://www.unboundmedicine.com/medline/citation/15455265/Effects_of_melatonin_on_acute_necrotizing_pancreatitis_in_rats_ DB - PRIME DP - Unbound Medicine ER -