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[Effects of genistein on bone mineral density and biomechanical properties and morphometric parameters in ovariectomized rats].
Wei Sheng Yan Jiu. 2004 Jul; 33(4):464-6.WS

Abstract

OBJECTIVE

To investigate the effects of genistein on bone mineral density and biomechanical properties and morphometric parameters in ovariectomized rats.

METHODS

Forty-seven Wistar rats were randomly allocated into six groups: sham-operated (sham), ovarietomized (ovx), ovarietomized supplied with diethyl stilbestrol (E, 20 microg/kg BW) or genistetin (25, 50, 100 mg/kg BW). After the rats had been fed for three months, the bone mineral density and biomechanical properties and histomorphometric parameters of the rats was analysed.

RESULTS

The trabecular bone volume and the mean trabecular plate density and bone density of ovariectomized rats were significantly decreased, while the mean trabecular plate space increased compared with sham animals. After three months supplementation to ovariectomized rats, trabecular bone volume and mean trabecular plate density increased.

CONCLUSION

Genistein can reduced bone loss on ovariecromized rats.

Authors+Show Affiliations

Department of Nutrition, General Hospital of Chinese PLA, Beijing 100853, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15461278

Citation

Zhang, Yuehong, et al. "[Effects of Genistein On Bone Mineral Density and Biomechanical Properties and Morphometric Parameters in Ovariectomized Rats]." Wei Sheng Yan Jiu = Journal of Hygiene Research, vol. 33, no. 4, 2004, pp. 464-6.
Zhang Y, Jin H, Xu Z, et al. [Effects of genistein on bone mineral density and biomechanical properties and morphometric parameters in ovariectomized rats]. Wei Sheng Yan Jiu. 2004;33(4):464-6.
Zhang, Y., Jin, H., Xu, Z., Nan, W., Wang, X., Xue, C., & Gao, L. (2004). [Effects of genistein on bone mineral density and biomechanical properties and morphometric parameters in ovariectomized rats]. Wei Sheng Yan Jiu = Journal of Hygiene Research, 33(4), 464-6.
Zhang Y, et al. [Effects of Genistein On Bone Mineral Density and Biomechanical Properties and Morphometric Parameters in Ovariectomized Rats]. Wei Sheng Yan Jiu. 2004;33(4):464-6. PubMed PMID: 15461278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of genistein on bone mineral density and biomechanical properties and morphometric parameters in ovariectomized rats]. AU - Zhang,Yuehong, AU - Jin,Hong, AU - Xu,Zhiqin, AU - Nan,Wenkao, AU - Wang,Xianyuan, AU - Xue,Changyong, AU - Gao,Lanxing, PY - 2004/10/6/pubmed PY - 2006/7/28/medline PY - 2004/10/6/entrez SP - 464 EP - 6 JF - Wei sheng yan jiu = Journal of hygiene research JO - Wei Sheng Yan Jiu VL - 33 IS - 4 N2 - OBJECTIVE: To investigate the effects of genistein on bone mineral density and biomechanical properties and morphometric parameters in ovariectomized rats. METHODS: Forty-seven Wistar rats were randomly allocated into six groups: sham-operated (sham), ovarietomized (ovx), ovarietomized supplied with diethyl stilbestrol (E, 20 microg/kg BW) or genistetin (25, 50, 100 mg/kg BW). After the rats had been fed for three months, the bone mineral density and biomechanical properties and histomorphometric parameters of the rats was analysed. RESULTS: The trabecular bone volume and the mean trabecular plate density and bone density of ovariectomized rats were significantly decreased, while the mean trabecular plate space increased compared with sham animals. After three months supplementation to ovariectomized rats, trabecular bone volume and mean trabecular plate density increased. CONCLUSION: Genistein can reduced bone loss on ovariecromized rats. SN - 1000-8020 UR - https://www.unboundmedicine.com/medline/citation/15461278/[Effects_of_genistein_on_bone_mineral_density_and_biomechanical_properties_and_morphometric_parameters_in_ovariectomized_rats]_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -