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[Indication of surgical therapy for Parkinson's disease].
Nihon Rinsho. 2004 Sep; 62(9):1691-5.NR

Abstract

We review the current status of surgical treatment of Parkinson's disease (PD). The advantages of deep brain stimulation (DBS) over ablative surgery include reversibility and controllability of stimulation. In addition, DBS carries a smaller risk of side effects, especially when employed bilaterally. DBS of the thalamus is useful to control tremor which is unresponsive to medication. DBS of the globus pallidus internus (GPi) or the subthalamic nucleus (STN) is useful to control wearing off of motor symptoms which is difficult to manage with medication alone. DBS of STN and GPi improves motor function mainly during the off-period. DBS of STN attenuates levodopa-induced dyskinesia through reduction of dopa requirement, whereas DBS of GPi attenuates dopa-induced dyskinesia directly. DBS of STN is also useful to control symptoms of PD in patients who are intolerant to dopa. However, DBS of either STN or GPi cannot reverse advanced symptoms of PD, which are unresponsive to dopa.

Authors+Show Affiliations

Department of Neurological Surgery, Nihon University School of Medicine and Division of Applied System Neuroscience, Graduate School of Medical Science.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

15462386

Citation

Katayama, Yoichi, and Kazutaka Kobayashi. "[Indication of Surgical Therapy for Parkinson's Disease]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 62, no. 9, 2004, pp. 1691-5.
Katayama Y, Kobayashi K. [Indication of surgical therapy for Parkinson's disease]. Nihon Rinsho. 2004;62(9):1691-5.
Katayama, Y., & Kobayashi, K. (2004). [Indication of surgical therapy for Parkinson's disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 62(9), 1691-5.
Katayama Y, Kobayashi K. [Indication of Surgical Therapy for Parkinson's Disease]. Nihon Rinsho. 2004;62(9):1691-5. PubMed PMID: 15462386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Indication of surgical therapy for Parkinson's disease]. AU - Katayama,Yoichi, AU - Kobayashi,Kazutaka, PY - 2004/10/7/pubmed PY - 2004/11/9/medline PY - 2004/10/7/entrez SP - 1691 EP - 5 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nihon Rinsho VL - 62 IS - 9 N2 - We review the current status of surgical treatment of Parkinson's disease (PD). The advantages of deep brain stimulation (DBS) over ablative surgery include reversibility and controllability of stimulation. In addition, DBS carries a smaller risk of side effects, especially when employed bilaterally. DBS of the thalamus is useful to control tremor which is unresponsive to medication. DBS of the globus pallidus internus (GPi) or the subthalamic nucleus (STN) is useful to control wearing off of motor symptoms which is difficult to manage with medication alone. DBS of STN and GPi improves motor function mainly during the off-period. DBS of STN attenuates levodopa-induced dyskinesia through reduction of dopa requirement, whereas DBS of GPi attenuates dopa-induced dyskinesia directly. DBS of STN is also useful to control symptoms of PD in patients who are intolerant to dopa. However, DBS of either STN or GPi cannot reverse advanced symptoms of PD, which are unresponsive to dopa. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/15462386/[Indication_of_surgical_therapy_for_Parkinson's_disease]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -
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