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Amygdala and "emotional" modulation of the relative use of multiple memory systems.
Neurobiol Learn Mem. 2004 Nov; 82(3):243-52.NL

Abstract

The basolateral amygdala modulates the cognitive and habit memory processes mediated by the hippocampus and caudate nucleus, respectively. The present experiments used a plus-maze task that can be acquired using either hippocampus-dependent "place" learning or caudate-dependent "response" learning to examine whether peripheral or intra-basolateral amygdala injection of anxiogenic drugs would bias rats towards the use of a particular memory system. In Experiment 1, adult male Long-Evans rats were trained to swim from the same start point to an escape platform located in a consistent goal arm, and received pre-training peripheral injections of the alpha(2)-adrenoceptor antagonists yohimbine (2.5 or 5.0 mg/kg), RS 79948-197 (0.05, 0.1, or 0.2 mg/kg), or vehicle. On a drug-free probe trial from a novel start point administered 24h following acquisition, vehicle treated rats predominantly displayed hippocampus-dependent place learning, whereas rats previously treated with yohimbine (2.5, 5.0 mg/kg) or RS 79948-197 (0.1 mg/kg) predominantly displayed caudate-dependent response learning. In Experiment 2, rats receiving pre-training intra-basolateral amygdala infusions of RS 79948-197 (0.1 microg/0.5 microl) also predominantly displayed response learning on a drug-free probe trial. The findings indicate (1) peripheral injections of anxiogenic drugs can influence the relative use of multiple memory systems in a manner that favors caudate-dependent habit learning over hippocampus-dependent cognitive learning, and (2) intra-basolateral amygdala infusion of anxiogenic drugs is sufficient to produce this modulatory influence of emotional state on the use of multiple memory systems.

Authors+Show Affiliations

Department of Psychology, Texas A and M University, USA. gp@psyc.tamu.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15464407

Citation

Packard, Mark G., and Jeffrey C. Wingard. "Amygdala and "emotional" Modulation of the Relative Use of Multiple Memory Systems." Neurobiology of Learning and Memory, vol. 82, no. 3, 2004, pp. 243-52.
Packard MG, Wingard JC. Amygdala and "emotional" modulation of the relative use of multiple memory systems. Neurobiol Learn Mem. 2004;82(3):243-52.
Packard, M. G., & Wingard, J. C. (2004). Amygdala and "emotional" modulation of the relative use of multiple memory systems. Neurobiology of Learning and Memory, 82(3), 243-52.
Packard MG, Wingard JC. Amygdala and "emotional" Modulation of the Relative Use of Multiple Memory Systems. Neurobiol Learn Mem. 2004;82(3):243-52. PubMed PMID: 15464407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Amygdala and "emotional" modulation of the relative use of multiple memory systems. AU - Packard,Mark G, AU - Wingard,Jeffrey C, PY - 2004/03/19/received PY - 2004/06/16/revised PY - 2004/06/23/accepted PY - 2004/10/7/pubmed PY - 2005/1/14/medline PY - 2004/10/7/entrez SP - 243 EP - 52 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 82 IS - 3 N2 - The basolateral amygdala modulates the cognitive and habit memory processes mediated by the hippocampus and caudate nucleus, respectively. The present experiments used a plus-maze task that can be acquired using either hippocampus-dependent "place" learning or caudate-dependent "response" learning to examine whether peripheral or intra-basolateral amygdala injection of anxiogenic drugs would bias rats towards the use of a particular memory system. In Experiment 1, adult male Long-Evans rats were trained to swim from the same start point to an escape platform located in a consistent goal arm, and received pre-training peripheral injections of the alpha(2)-adrenoceptor antagonists yohimbine (2.5 or 5.0 mg/kg), RS 79948-197 (0.05, 0.1, or 0.2 mg/kg), or vehicle. On a drug-free probe trial from a novel start point administered 24h following acquisition, vehicle treated rats predominantly displayed hippocampus-dependent place learning, whereas rats previously treated with yohimbine (2.5, 5.0 mg/kg) or RS 79948-197 (0.1 mg/kg) predominantly displayed caudate-dependent response learning. In Experiment 2, rats receiving pre-training intra-basolateral amygdala infusions of RS 79948-197 (0.1 microg/0.5 microl) also predominantly displayed response learning on a drug-free probe trial. The findings indicate (1) peripheral injections of anxiogenic drugs can influence the relative use of multiple memory systems in a manner that favors caudate-dependent habit learning over hippocampus-dependent cognitive learning, and (2) intra-basolateral amygdala infusion of anxiogenic drugs is sufficient to produce this modulatory influence of emotional state on the use of multiple memory systems. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/15464407/Amygdala_and_"emotional"_modulation_of_the_relative_use_of_multiple_memory_systems_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(04)00076-0 DB - PRIME DP - Unbound Medicine ER -