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Comparison of posterior capsule opacification between the 1-piece and 3-piece Acrysof intraocular lenses: two-year results of a randomized trial.
Ophthalmology. 2004 Oct; 111(10):1840-6.O

Abstract

PURPOSE

To compare intensity of posterior capsule opacification (PCO) between the 1-piece and 3-piece haptic designs of an open-loop hydrophobic acrylic intraocular lens (IOL).

DESIGN

A randomized, patient- and examiner-masked clinical trial with intraindividual comparison.

PARTICIPANTS

Fifty-two patients with bilateral age-related cataract (104 eyes).

METHODS

Each patient had cataract surgery in both eyes and received a 1-piece Acrysof IOL in one eye and a 3-piece Acrysof IOL in the fellow eye. Follow-up examinations were at 1 week, 1 month, 6 months, 1 year, and 2 years. Patients were examined at the slit lamp, visual acuity (VA) was determined, and standardized high-resolution digital retroillumination images of the posterior capsule were taken. The intensity of PCO was assessed subjectively at the slit lamp and objectively using automated image analysis software.

MAIN OUTCOME MEASURE

Posterior capsule opacification score (scale, 0-10).

RESULTS

There was no significant difference between IOL styles in best-corrected VA, rhexis/IOL overlap, capsular folds, and amount of anterior capsule opacification during the follow-up period. One year postoperatively, the amount of regeneratory PCO was higher for the 1-piece Acrysof eyes (image analysis software score: 1.3) than for the 3-piece Acrysof eyes (score: 0.9; P = 0.002). However, 2 years postoperatively, there was no significant difference between the 2 IOL styles (1-piece: 1.5; 3-piece: 1.3; P = 0.3). Neodymium:yttrium-aluminum-garnet capsulotomy was not performed in the study.

CONCLUSION

One year postoperatively, the 1-piece Acrysof showed slightly more regeneratory PCO than the 3-piece Acrysof. However, 2 years postoperatively, the barrier effect of the 1-piece design was comparable to that of the 3-piece haptic design, with low PCO intensity.

Authors+Show Affiliations

Department of Ophthalmology, Medical University Vienna, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15465544

Citation

Sacu, Stefan, et al. "Comparison of Posterior Capsule Opacification Between the 1-piece and 3-piece Acrysof Intraocular Lenses: Two-year Results of a Randomized Trial." Ophthalmology, vol. 111, no. 10, 2004, pp. 1840-6.
Sacu S, Findl O, Menapace R, et al. Comparison of posterior capsule opacification between the 1-piece and 3-piece Acrysof intraocular lenses: two-year results of a randomized trial. Ophthalmology. 2004;111(10):1840-6.
Sacu, S., Findl, O., Menapace, R., Buehl, W., & Wirtitsch, M. (2004). Comparison of posterior capsule opacification between the 1-piece and 3-piece Acrysof intraocular lenses: two-year results of a randomized trial. Ophthalmology, 111(10), 1840-6.
Sacu S, et al. Comparison of Posterior Capsule Opacification Between the 1-piece and 3-piece Acrysof Intraocular Lenses: Two-year Results of a Randomized Trial. Ophthalmology. 2004;111(10):1840-6. PubMed PMID: 15465544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of posterior capsule opacification between the 1-piece and 3-piece Acrysof intraocular lenses: two-year results of a randomized trial. AU - Sacu,Stefan, AU - Findl,Oliver, AU - Menapace,Rupert, AU - Buehl,Wolf, AU - Wirtitsch,Mathias, PY - 2003/12/26/received PY - 2004/03/05/accepted PY - 2004/10/7/pubmed PY - 2004/10/22/medline PY - 2004/10/7/entrez SP - 1840 EP - 6 JF - Ophthalmology JO - Ophthalmology VL - 111 IS - 10 N2 - PURPOSE: To compare intensity of posterior capsule opacification (PCO) between the 1-piece and 3-piece haptic designs of an open-loop hydrophobic acrylic intraocular lens (IOL). DESIGN: A randomized, patient- and examiner-masked clinical trial with intraindividual comparison. PARTICIPANTS: Fifty-two patients with bilateral age-related cataract (104 eyes). METHODS: Each patient had cataract surgery in both eyes and received a 1-piece Acrysof IOL in one eye and a 3-piece Acrysof IOL in the fellow eye. Follow-up examinations were at 1 week, 1 month, 6 months, 1 year, and 2 years. Patients were examined at the slit lamp, visual acuity (VA) was determined, and standardized high-resolution digital retroillumination images of the posterior capsule were taken. The intensity of PCO was assessed subjectively at the slit lamp and objectively using automated image analysis software. MAIN OUTCOME MEASURE: Posterior capsule opacification score (scale, 0-10). RESULTS: There was no significant difference between IOL styles in best-corrected VA, rhexis/IOL overlap, capsular folds, and amount of anterior capsule opacification during the follow-up period. One year postoperatively, the amount of regeneratory PCO was higher for the 1-piece Acrysof eyes (image analysis software score: 1.3) than for the 3-piece Acrysof eyes (score: 0.9; P = 0.002). However, 2 years postoperatively, there was no significant difference between the 2 IOL styles (1-piece: 1.5; 3-piece: 1.3; P = 0.3). Neodymium:yttrium-aluminum-garnet capsulotomy was not performed in the study. CONCLUSION: One year postoperatively, the 1-piece Acrysof showed slightly more regeneratory PCO than the 3-piece Acrysof. However, 2 years postoperatively, the barrier effect of the 1-piece design was comparable to that of the 3-piece haptic design, with low PCO intensity. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/15465544/Comparison_of_posterior_capsule_opacification_between_the_1_piece_and_3_piece_Acrysof_intraocular_lenses:_two_year_results_of_a_randomized_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(04)00561-5 DB - PRIME DP - Unbound Medicine ER -