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Neutrophils as a specific target for melatonin and kynuramines: effects on cytokine release.
J Neuroimmunol. 2004 Nov; 156(1-2):146-52.JN

Abstract

A growing body of evidence suggests that the pineal hormone, melatonin, has immunomodulatory properties, although very little is known about its effect on leukocytes. Therefore, we aimed to investigate the effect of melatonin and its oxidation product N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) on cytokine production by neutrophils and peripheral blood mononuclear cells (PBMCs). AFMK (0.001-1 mM) inhibits the lipopolysaccharide (LPS)-mediated production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) more efficiently in neutrophils than PBMCs. Moreover, the inhibitory activity of AFMK is stronger than that of melatonin. Interestingly, monocytes efficiently oxidize melatonin to AFMK. We conclude that neutrophils are one of the main targets for melatonin and that at least part of the effects described for melatonin on immune cells may be due to its oxidation product, AFMK. We also consider that the oxidation of melatonin may be an important event in the cross-talking between neutrophils and monocytes.

Authors+Show Affiliations

Silva SO
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo CEP 05508-900, SP, Brazil.
Rodrigues MR
No affiliation info available
Ximenes VF
No affiliation info available
Bueno-da-Silva AE
No affiliation info available
Amarante-Mendes GP
No affiliation info available
Campa A
No affiliation info available

MeSH

Analysis of VarianceCells, CulturedCytokinesHumansKynuramineMelatoninNeutrophilsOxidation-Reduction

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15465605

Citation

Silva, S O., et al. "Neutrophils as a Specific Target for Melatonin and Kynuramines: Effects On Cytokine Release." Journal of Neuroimmunology, vol. 156, no. 1-2, 2004, pp. 146-52.
Silva SO, Rodrigues MR, Ximenes VF, et al. Neutrophils as a specific target for melatonin and kynuramines: effects on cytokine release. J Neuroimmunol. 2004;156(1-2):146-52.
Silva, S. O., Rodrigues, M. R., Ximenes, V. F., Bueno-da-Silva, A. E., Amarante-Mendes, G. P., & Campa, A. (2004). Neutrophils as a specific target for melatonin and kynuramines: effects on cytokine release. Journal of Neuroimmunology, 156(1-2), 146-52.
Silva SO, et al. Neutrophils as a Specific Target for Melatonin and Kynuramines: Effects On Cytokine Release. J Neuroimmunol. 2004;156(1-2):146-52. PubMed PMID: 15465605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neutrophils as a specific target for melatonin and kynuramines: effects on cytokine release. AU - Silva,S O, AU - Rodrigues,M R, AU - Ximenes,V F, AU - Bueno-da-Silva,A E B, AU - Amarante-Mendes,G P, AU - Campa,A, PY - 2004/03/15/received PY - 2004/07/19/revised PY - 2004/07/28/accepted PY - 2004/10/7/pubmed PY - 2004/12/16/medline PY - 2004/10/7/entrez SP - 146 EP - 52 JF - Journal of neuroimmunology JO - J Neuroimmunol VL - 156 IS - 1-2 N2 - A growing body of evidence suggests that the pineal hormone, melatonin, has immunomodulatory properties, although very little is known about its effect on leukocytes. Therefore, we aimed to investigate the effect of melatonin and its oxidation product N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) on cytokine production by neutrophils and peripheral blood mononuclear cells (PBMCs). AFMK (0.001-1 mM) inhibits the lipopolysaccharide (LPS)-mediated production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) more efficiently in neutrophils than PBMCs. Moreover, the inhibitory activity of AFMK is stronger than that of melatonin. Interestingly, monocytes efficiently oxidize melatonin to AFMK. We conclude that neutrophils are one of the main targets for melatonin and that at least part of the effects described for melatonin on immune cells may be due to its oxidation product, AFMK. We also consider that the oxidation of melatonin may be an important event in the cross-talking between neutrophils and monocytes. SN - 0165-5728 UR - https://www.unboundmedicine.com/medline/citation/15465605/Neutrophils_as_a_specific_target_for_melatonin_and_kynuramines:_effects_on_cytokine_release_ DB - PRIME DP - Unbound Medicine ER -