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Facilitation of fear extinction by D-cycloserine: theoretical and clinical implications.
Learn Mem. 2004 Sep-Oct; 11(5):510-6.LM

Abstract

Anxiety disorders are among the most common psychological disturbances in the industrialized world. Current behavioral therapy procedures for these disorders are somewhat effective, but their efficacy could be substantially improved. Because these procedures are largely based on the process of extinction, manipulations that enhance extinction may lead to improvements in treatment effectiveness. We review the evidence that D-cycloserine (DCS), a partial NMDA agonist, facilitates extinction of learned fear in rats. Although only a few studies have examined the effects of DCS on extinction of learned fear, this work suggests that this drug may have a number of potential clinical benefits. In addition, attempts at interpreting this research illustrate our limited understanding of the processes involved in extinction.

Authors+Show Affiliations

School of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia. r.richardson@unsw.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15466301

Citation

Richardson, Rick, et al. "Facilitation of Fear Extinction By D-cycloserine: Theoretical and Clinical Implications." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 11, no. 5, 2004, pp. 510-6.
Richardson R, Ledgerwood L, Cranney J. Facilitation of fear extinction by D-cycloserine: theoretical and clinical implications. Learn Mem. 2004;11(5):510-6.
Richardson, R., Ledgerwood, L., & Cranney, J. (2004). Facilitation of fear extinction by D-cycloserine: theoretical and clinical implications. Learning & Memory (Cold Spring Harbor, N.Y.), 11(5), 510-6.
Richardson R, Ledgerwood L, Cranney J. Facilitation of Fear Extinction By D-cycloserine: Theoretical and Clinical Implications. Learn Mem. 2004 Sep-Oct;11(5):510-6. PubMed PMID: 15466301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Facilitation of fear extinction by D-cycloserine: theoretical and clinical implications. AU - Richardson,Rick, AU - Ledgerwood,Lana, AU - Cranney,Jacquelyn, PY - 2004/10/7/pubmed PY - 2005/1/7/medline PY - 2004/10/7/entrez SP - 510 EP - 6 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 11 IS - 5 N2 - Anxiety disorders are among the most common psychological disturbances in the industrialized world. Current behavioral therapy procedures for these disorders are somewhat effective, but their efficacy could be substantially improved. Because these procedures are largely based on the process of extinction, manipulations that enhance extinction may lead to improvements in treatment effectiveness. We review the evidence that D-cycloserine (DCS), a partial NMDA agonist, facilitates extinction of learned fear in rats. Although only a few studies have examined the effects of DCS on extinction of learned fear, this work suggests that this drug may have a number of potential clinical benefits. In addition, attempts at interpreting this research illustrate our limited understanding of the processes involved in extinction. SN - 1072-0502 UR - https://www.unboundmedicine.com/medline/citation/15466301/Facilitation_of_fear_extinction_by_D_cycloserine:_theoretical_and_clinical_implications_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:15466301 DB - PRIME DP - Unbound Medicine ER -