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Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study.
Am J Epidemiol 2004; 160(8):741-9AJ

Abstract

Assessment of body fat distribution, particularly visceral adipose tissue, may be important for accurate risk evaluation for cardiovascular disease in the elderly. This 1997-1998 US study examined the association of incident myocardial infarction (MI) with total adiposity (body mass index and fat mass) and body fat distribution (waist-to-thigh ratio, waist circumference, visceral and subcutaneous adipose tissue) in well-functioning men (n = 1,116) and women (n = 1,387) aged 70-79 years enrolled in the Health, Aging and Body Composition Study. There were 116 MI events (71 in men, 45 in women) during an average follow-up time of 4.6 (standard deviation, 0.9) years. No association was found between incident MI and the adiposity or fat distribution variables for men. For women, visceral adipose tissue was an independent predictor of MI (hazard ratio = 1.67, 95% confidence interval: 1.28, 2.17 per standard-deviation increase; p < 0.001). No association was found between body mass index or total fat mass and MI events in women. The association of visceral adipose tissue with MI in women was independent of high density lipoprotein cholesterol, interleukin-6 concentration, hypertension, and diabetes (hazard ratio = 1.79, 95% confidence interval: 1.24, 2.58 per standard-deviation increase; p < 0.01). The amount of adipose tissue stored in the intraabdominal cavity is an important, independent risk factor for MI in well-functioning, elderly women.

Authors+Show Affiliations

Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, NC, USA. bnicklas@wfubmc.edu <bnicklas@wfubmc.edu>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15466496

Citation

Nicklas, Barbara J., et al. "Association of Visceral Adipose Tissue With Incident Myocardial Infarction in Older Men and Women: the Health, Aging and Body Composition Study." American Journal of Epidemiology, vol. 160, no. 8, 2004, pp. 741-9.
Nicklas BJ, Penninx BW, Cesari M, et al. Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study. Am J Epidemiol. 2004;160(8):741-9.
Nicklas, B. J., Penninx, B. W., Cesari, M., Kritchevsky, S. B., Newman, A. B., Kanaya, A. M., ... Harris, T. B. (2004). Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study. American Journal of Epidemiology, 160(8), pp. 741-9.
Nicklas BJ, et al. Association of Visceral Adipose Tissue With Incident Myocardial Infarction in Older Men and Women: the Health, Aging and Body Composition Study. Am J Epidemiol. 2004 Oct 15;160(8):741-9. PubMed PMID: 15466496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study. AU - Nicklas,Barbara J, AU - Penninx,Brenda W J H, AU - Cesari,Matteo, AU - Kritchevsky,Stephen B, AU - Newman,Anne B, AU - Kanaya,Alka M, AU - Pahor,Marco, AU - Jingzhong,Ding, AU - Harris,Tamara B, AU - ,, PY - 2004/10/7/pubmed PY - 2004/11/4/medline PY - 2004/10/7/entrez SP - 741 EP - 9 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 160 IS - 8 N2 - Assessment of body fat distribution, particularly visceral adipose tissue, may be important for accurate risk evaluation for cardiovascular disease in the elderly. This 1997-1998 US study examined the association of incident myocardial infarction (MI) with total adiposity (body mass index and fat mass) and body fat distribution (waist-to-thigh ratio, waist circumference, visceral and subcutaneous adipose tissue) in well-functioning men (n = 1,116) and women (n = 1,387) aged 70-79 years enrolled in the Health, Aging and Body Composition Study. There were 116 MI events (71 in men, 45 in women) during an average follow-up time of 4.6 (standard deviation, 0.9) years. No association was found between incident MI and the adiposity or fat distribution variables for men. For women, visceral adipose tissue was an independent predictor of MI (hazard ratio = 1.67, 95% confidence interval: 1.28, 2.17 per standard-deviation increase; p < 0.001). No association was found between body mass index or total fat mass and MI events in women. The association of visceral adipose tissue with MI in women was independent of high density lipoprotein cholesterol, interleukin-6 concentration, hypertension, and diabetes (hazard ratio = 1.79, 95% confidence interval: 1.24, 2.58 per standard-deviation increase; p < 0.01). The amount of adipose tissue stored in the intraabdominal cavity is an important, independent risk factor for MI in well-functioning, elderly women. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15466496/Association_of_visceral_adipose_tissue_with_incident_myocardial_infarction_in_older_men_and_women:_the_Health_Aging_and_Body_Composition_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwh281 DB - PRIME DP - Unbound Medicine ER -