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Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens.
Arch Pediatr Adolesc Med. 2004 Oct; 158(10):996-1001.AP

Abstract

OBJECTIVE

To investigate the effect of pet ownership and exposure to indoor allergens on lung function in 3-year-old children.

DESIGN

Birth cohort study.

SETTING

Community.

PARTICIPANTS

Children recruited prenatally and followed prospectively to age 3 years.

MAIN OUTCOME MEASURES

Specific airway resistance (sRaw) (measured with body plethysmograph) at age 3 years; skin-prick tests; data on cat and dog ownership collected prospectively; allergen levels measured in dust collected from homes (high exposure defined as mite allergens >2 microg/g in mattress, and dog >10 microg/g and cat >8 microg/g allergens on the living room floor).

RESULTS

There was no effect of cat or dog ownership at birth or age 3 years on lung function, and no association between lung function and mite, dog, or cat allergen exposure. Sensitized children exposed to high levels of sensitizing allergen had significantly poorer lung function (n = 49, sRaw kiloPascal per second [kPa/s]; geometric mean [GM], 1.20; 95% confidence interval [CI], 1.13-1.28) than children who were not sensitized and not exposed (n = 114; GM, 1.08; 95% CI, 1.04-1.12); not sensitized, but exposed (n = 282; GM, 1.07; 95% CI, 1.05-1.10); or sensitized and not exposed (n = 53; GM, 1.12; 95% CI, 1.06-1.18; P = .005). In a multivariate model, independent significant associates of lung function were maternal and paternal asthma, and the combination of sensitization and exposure to sensitizing allergen, with significant interaction between them. Lung function was substantially worse in sensitized and highly exposed children with both asthmatic parents (GM, 2.23; 95% CI, 1.68-2.97), compared with those with neither (GM, 1.09; 95% CI, 1.04-1.16) or just 1 of these features.

CONCLUSIONS

Pet ownership, sensitization without exposure, or exposure in nonsensitized individuals have no effect on lung function. However, the combination of specific sensitization and exposure to sensitizing allergen is associated with significantly poorer lung function in early life.

Authors+Show Affiliations

North West Lung Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15466689

Citation

Lowe, Lesley A., et al. "Lung Function at Age 3 Years: Effect of Pet Ownership and Exposure to Indoor Allergens." Archives of Pediatrics & Adolescent Medicine, vol. 158, no. 10, 2004, pp. 996-1001.
Lowe LA, Woodcock A, Murray CS, et al. Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens. Arch Pediatr Adolesc Med. 2004;158(10):996-1001.
Lowe, L. A., Woodcock, A., Murray, C. S., Morris, J., Simpson, A., & Custovic, A. (2004). Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens. Archives of Pediatrics & Adolescent Medicine, 158(10), 996-1001.
Lowe LA, et al. Lung Function at Age 3 Years: Effect of Pet Ownership and Exposure to Indoor Allergens. Arch Pediatr Adolesc Med. 2004;158(10):996-1001. PubMed PMID: 15466689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens. AU - Lowe,Lesley A, AU - Woodcock,Ashley, AU - Murray,Clare S, AU - Morris,Julie, AU - Simpson,Angela, AU - Custovic,Adnan, PY - 2004/10/7/pubmed PY - 2004/11/9/medline PY - 2004/10/7/entrez SP - 996 EP - 1001 JF - Archives of pediatrics & adolescent medicine JO - Arch Pediatr Adolesc Med VL - 158 IS - 10 N2 - OBJECTIVE: To investigate the effect of pet ownership and exposure to indoor allergens on lung function in 3-year-old children. DESIGN: Birth cohort study. SETTING: Community. PARTICIPANTS: Children recruited prenatally and followed prospectively to age 3 years. MAIN OUTCOME MEASURES: Specific airway resistance (sRaw) (measured with body plethysmograph) at age 3 years; skin-prick tests; data on cat and dog ownership collected prospectively; allergen levels measured in dust collected from homes (high exposure defined as mite allergens >2 microg/g in mattress, and dog >10 microg/g and cat >8 microg/g allergens on the living room floor). RESULTS: There was no effect of cat or dog ownership at birth or age 3 years on lung function, and no association between lung function and mite, dog, or cat allergen exposure. Sensitized children exposed to high levels of sensitizing allergen had significantly poorer lung function (n = 49, sRaw kiloPascal per second [kPa/s]; geometric mean [GM], 1.20; 95% confidence interval [CI], 1.13-1.28) than children who were not sensitized and not exposed (n = 114; GM, 1.08; 95% CI, 1.04-1.12); not sensitized, but exposed (n = 282; GM, 1.07; 95% CI, 1.05-1.10); or sensitized and not exposed (n = 53; GM, 1.12; 95% CI, 1.06-1.18; P = .005). In a multivariate model, independent significant associates of lung function were maternal and paternal asthma, and the combination of sensitization and exposure to sensitizing allergen, with significant interaction between them. Lung function was substantially worse in sensitized and highly exposed children with both asthmatic parents (GM, 2.23; 95% CI, 1.68-2.97), compared with those with neither (GM, 1.09; 95% CI, 1.04-1.16) or just 1 of these features. CONCLUSIONS: Pet ownership, sensitization without exposure, or exposure in nonsensitized individuals have no effect on lung function. However, the combination of specific sensitization and exposure to sensitizing allergen is associated with significantly poorer lung function in early life. SN - 1072-4710 UR - https://www.unboundmedicine.com/medline/citation/15466689/Lung_function_at_age_3_years:_effect_of_pet_ownership_and_exposure_to_indoor_allergens_ L2 - https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/archpedi.158.10.996 DB - PRIME DP - Unbound Medicine ER -