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Antioxidant activity of jionoside D from Clerodendron trichotomum.
Biol Pharm Bull. 2004 Oct; 27(10):1504-8.BP

Abstract

The antioxidant property of jionoside D, isolated from Clerodendron trichotomum (Verbenaceae), was investigated. This compound showed scavenging activity of intracellular reactive oxygen species and of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as lipid peroxidation inhibitory activity. This radical scavenging activity of jionoside D protected the cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed H2O2. Furthermore, jionoside D reduced the apoptotic cells induced by H2O2, as demonstrated by the decreased number of sub G1 hypo-diploid cells and apoptotic body formation. However, it increased the activities of cellular antioxidant enzymes, superoxide dismutase and catalase. Taken together, these findings suggest that jionoside D, isolated from C. trichotomum, exhibits antioxidant properties.

Authors+Show Affiliations

Natural Products Research Institute, Seoul National University, Yeunkun dong, Chongno ku, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15467185

Citation

Chae, Sungwook, et al. "Antioxidant Activity of Jionoside D From Clerodendron Trichotomum." Biological & Pharmaceutical Bulletin, vol. 27, no. 10, 2004, pp. 1504-8.
Chae S, Kim JS, Kang KA, et al. Antioxidant activity of jionoside D from Clerodendron trichotomum. Biol Pharm Bull. 2004;27(10):1504-8.
Chae, S., Kim, J. S., Kang, K. A., Bu, H. D., Lee, Y., Hyun, J. W., & Kang, S. S. (2004). Antioxidant activity of jionoside D from Clerodendron trichotomum. Biological & Pharmaceutical Bulletin, 27(10), 1504-8.
Chae S, et al. Antioxidant Activity of Jionoside D From Clerodendron Trichotomum. Biol Pharm Bull. 2004;27(10):1504-8. PubMed PMID: 15467185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity of jionoside D from Clerodendron trichotomum. AU - Chae,Sungwook, AU - Kim,Ju Sun, AU - Kang,Kyoung Ah, AU - Bu,Hyung Deuk, AU - Lee,Youngki, AU - Hyun,Jin Won, AU - Kang,Sam Sik, PY - 2004/10/7/pubmed PY - 2005/7/9/medline PY - 2004/10/7/entrez SP - 1504 EP - 8 JF - Biological & pharmaceutical bulletin JO - Biol Pharm Bull VL - 27 IS - 10 N2 - The antioxidant property of jionoside D, isolated from Clerodendron trichotomum (Verbenaceae), was investigated. This compound showed scavenging activity of intracellular reactive oxygen species and of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as lipid peroxidation inhibitory activity. This radical scavenging activity of jionoside D protected the cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed H2O2. Furthermore, jionoside D reduced the apoptotic cells induced by H2O2, as demonstrated by the decreased number of sub G1 hypo-diploid cells and apoptotic body formation. However, it increased the activities of cellular antioxidant enzymes, superoxide dismutase and catalase. Taken together, these findings suggest that jionoside D, isolated from C. trichotomum, exhibits antioxidant properties. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/15467185/Antioxidant_activity_of_jionoside_D_from_Clerodendron_trichotomum_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/27.1504?from=PubMed DB - PRIME DP - Unbound Medicine ER -