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Effects of eplerenone, a selective aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy.
Pharmacology. 2005 Feb; 73(2):81-8.P

Abstract

Aldosterone blockade reduces morbidity and mortality in patients with heart failure. We studied the effects of eplerenone, a novel aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy after autoimmune myocarditis. Twenty-eight days after immunization, the surviving Lewis rats were randomized to 1 month's oral treatment with low-dose eplerenone (group L), high-dose eplerenone (group H) or vehicle (group V). Five of 15 (33%) rats in group V and 3 of 15 (20%) rats in group L died during the course of treatment. High-dose eplerenone significantly reduced cardiomyocyte hypertrophy, heart weight and heart weight to body weight ratio. Eplerenone improved left ventricular function in a dose-dependent manner. Central venous pressure and left ventricular end-diastolic pressure were lower, and +/-dP/dt and fractional shortening were higher in group H than group V. Eplerenone also attenuated myocardial fibrosis and reduced left ventricular mRNA expressions of TGF-beta(1) and collagen-III. Our results indicate that treatment with eplerenone improved left ventricular dysfunction and attenuated left ventricular remodeling in rats with heart failure.

Authors+Show Affiliations

Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata-shi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15467302

Citation

Wahed, Mir Imam Ibne, et al. "Effects of Eplerenone, a Selective Aldosterone Blocker, On the Progression of Left Ventricular Dysfunction and Remodeling in Rats With Dilated Cardiomyopathy." Pharmacology, vol. 73, no. 2, 2005, pp. 81-8.
Wahed MI, Watanabe K, Ma M, et al. Effects of eplerenone, a selective aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy. Pharmacology. 2005;73(2):81-8.
Wahed, M. I., Watanabe, K., Ma, M., Yamaguchi, K., Takahashi, T., Tachikawa, H., Kodama, M., & Aizawa, Y. (2005). Effects of eplerenone, a selective aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy. Pharmacology, 73(2), 81-8.
Wahed MI, et al. Effects of Eplerenone, a Selective Aldosterone Blocker, On the Progression of Left Ventricular Dysfunction and Remodeling in Rats With Dilated Cardiomyopathy. Pharmacology. 2005;73(2):81-8. PubMed PMID: 15467302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of eplerenone, a selective aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy. AU - Wahed,Mir Imam Ibne, AU - Watanabe,Kenichi, AU - Ma,Meilei, AU - Yamaguchi,Kenichi, AU - Takahashi,Toshihiro, AU - Tachikawa,Hitoshi, AU - Kodama,Makoto, AU - Aizawa,Yushifusa, Y1 - 2004/10/01/ PY - 2004/05/17/received PY - 2004/08/05/accepted PY - 2004/10/7/pubmed PY - 2005/4/5/medline PY - 2004/10/7/entrez SP - 81 EP - 8 JF - Pharmacology JO - Pharmacology VL - 73 IS - 2 N2 - Aldosterone blockade reduces morbidity and mortality in patients with heart failure. We studied the effects of eplerenone, a novel aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy after autoimmune myocarditis. Twenty-eight days after immunization, the surviving Lewis rats were randomized to 1 month's oral treatment with low-dose eplerenone (group L), high-dose eplerenone (group H) or vehicle (group V). Five of 15 (33%) rats in group V and 3 of 15 (20%) rats in group L died during the course of treatment. High-dose eplerenone significantly reduced cardiomyocyte hypertrophy, heart weight and heart weight to body weight ratio. Eplerenone improved left ventricular function in a dose-dependent manner. Central venous pressure and left ventricular end-diastolic pressure were lower, and +/-dP/dt and fractional shortening were higher in group H than group V. Eplerenone also attenuated myocardial fibrosis and reduced left ventricular mRNA expressions of TGF-beta(1) and collagen-III. Our results indicate that treatment with eplerenone improved left ventricular dysfunction and attenuated left ventricular remodeling in rats with heart failure. SN - 0031-7012 UR - https://www.unboundmedicine.com/medline/citation/15467302/Effects_of_eplerenone_a_selective_aldosterone_blocker_on_the_progression_of_left_ventricular_dysfunction_and_remodeling_in_rats_with_dilated_cardiomyopathy_ L2 - https://www.karger.com?DOI=10.1159/000081267 DB - PRIME DP - Unbound Medicine ER -