Tags

Type your tag names separated by a space and hit enter

The pathophysiology of irritable bowel syndrome.
Minerva Med. 2004 Oct; 95(5):419-26.MM

Abstract

Recent studies have provided evidence to suggest a possible role for mucosal immune activation in the pathophysiology of irritable bowel syndrome (IBS). On the other hand, novel findings using functional brain-imaging techniques support the concept that altered perception of visceral stimuli plays a key role in IBS symptom generation. These seemingly contradictory findings have revived the discussion about the relative contribution of peripheral versus central mechanisms in the symptom generation of IBS. In this review, we will provide evidence for the hypothesis that, in the absence of changes in visceral perception and alterations in endogenous pain modulation systems, chronic inflammatory mucosal changes in the gut are not a plausible mechanism to explain the presence of chronic abdominal pain, a clinical hallmark of IBS.

Authors+Show Affiliations

Center of Neurovisceral Sciences and Women's Health (CNS), Division of Digestive Diseases and Brain Research Institute, Department of Medicine, Los Angeles, CA, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15467517

Citation

Schwetz, I, et al. "The Pathophysiology of Irritable Bowel Syndrome." Minerva Medica, vol. 95, no. 5, 2004, pp. 419-26.
Schwetz I, Bradesi S, Mayer EA. The pathophysiology of irritable bowel syndrome. Minerva Med. 2004;95(5):419-26.
Schwetz, I., Bradesi, S., & Mayer, E. A. (2004). The pathophysiology of irritable bowel syndrome. Minerva Medica, 95(5), 419-26.
Schwetz I, Bradesi S, Mayer EA. The Pathophysiology of Irritable Bowel Syndrome. Minerva Med. 2004;95(5):419-26. PubMed PMID: 15467517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The pathophysiology of irritable bowel syndrome. AU - Schwetz,I, AU - Bradesi,S, AU - Mayer,E A, PY - 2004/10/7/pubmed PY - 2004/12/16/medline PY - 2004/10/7/entrez SP - 419 EP - 26 JF - Minerva medica JO - Minerva Med VL - 95 IS - 5 N2 - Recent studies have provided evidence to suggest a possible role for mucosal immune activation in the pathophysiology of irritable bowel syndrome (IBS). On the other hand, novel findings using functional brain-imaging techniques support the concept that altered perception of visceral stimuli plays a key role in IBS symptom generation. These seemingly contradictory findings have revived the discussion about the relative contribution of peripheral versus central mechanisms in the symptom generation of IBS. In this review, we will provide evidence for the hypothesis that, in the absence of changes in visceral perception and alterations in endogenous pain modulation systems, chronic inflammatory mucosal changes in the gut are not a plausible mechanism to explain the presence of chronic abdominal pain, a clinical hallmark of IBS. SN - 0026-4806 UR - https://www.unboundmedicine.com/medline/citation/15467517/The_pathophysiology_of_irritable_bowel_syndrome_ L2 - http://www.diseaseinfosearch.org/result/3876 DB - PRIME DP - Unbound Medicine ER -