Tags

Type your tag names separated by a space and hit enter

Cigarette smoking and Parkinson's disease: a case-control study in a population characterized by a high prevalence of pesticide exposure.
Mov Disord 2005; 20(2):181-9MD

Abstract

Epidemiological studies have been consistent in showing that cigarette smoking is inversely associated with Parkinson's disease (PD), whereas pesticide use is positively associated with PD. However, the relationship between PD and cigarette smoking remains poorly understood. Our objective was to study the relationship between cigarette smoking and PD in a population characterized by a high prevalence of pesticide exposure. This case-control study was carried out among subjects enrolled in the Mutualite Sociale Agricole, the French health insurance organization for workers connected to the agricultural world. We included 247 cases and 676 controls matched on age, sex, and region of residency. Information on smoking was obtained through in-person interviews. Pesticide exposure was assessed using a case-by-case expert evaluation procedure. We found an inverse relationship between ever cigarette smoking and PD (odds ratio [OR] = 0.6; 95% confidence interval [CI] = 0.4-0.9). The strength of this association increased with the number of pack-years. This relationship was present even when smoking was considered as long as 40 years before PD onset. An inverse association was also present among subjects professionally exposed to pesticides (OR = 0.5; 95% CI = 0.3-0.8) and was independent of the duration of exposure among men. We confirm the inverse association between cigarette smoking and PD in a population characterized by a high prevalence of professional pesticide exposure. The relationship between PD and cigarette smoking was not significantly modified or confounded by exposure to pesticides.

Authors+Show Affiliations

Institut National de la Santé et de la Recherche Médicale Unit 360, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15468111

Citation

Galanaud, Jean-Philippe, et al. "Cigarette Smoking and Parkinson's Disease: a Case-control Study in a Population Characterized By a High Prevalence of Pesticide Exposure." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 20, no. 2, 2005, pp. 181-9.
Galanaud JP, Elbaz A, Clavel J, et al. Cigarette smoking and Parkinson's disease: a case-control study in a population characterized by a high prevalence of pesticide exposure. Mov Disord. 2005;20(2):181-9.
Galanaud, J. P., Elbaz, A., Clavel, J., Vidal, J. S., Corrèze, J. R., Alpérovitch, A., & Tzourio, C. (2005). Cigarette smoking and Parkinson's disease: a case-control study in a population characterized by a high prevalence of pesticide exposure. Movement Disorders : Official Journal of the Movement Disorder Society, 20(2), pp. 181-9.
Galanaud JP, et al. Cigarette Smoking and Parkinson's Disease: a Case-control Study in a Population Characterized By a High Prevalence of Pesticide Exposure. Mov Disord. 2005;20(2):181-9. PubMed PMID: 15468111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and Parkinson's disease: a case-control study in a population characterized by a high prevalence of pesticide exposure. AU - Galanaud,Jean-Philippe, AU - Elbaz,Alexis, AU - Clavel,Jacqueline, AU - Vidal,Jean-Sébastien, AU - Corrèze,Jean-René, AU - Alpérovitch,Annick, AU - Tzourio,Christophe, PY - 2004/10/7/pubmed PY - 2005/4/26/medline PY - 2004/10/7/entrez SP - 181 EP - 9 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 20 IS - 2 N2 - Epidemiological studies have been consistent in showing that cigarette smoking is inversely associated with Parkinson's disease (PD), whereas pesticide use is positively associated with PD. However, the relationship between PD and cigarette smoking remains poorly understood. Our objective was to study the relationship between cigarette smoking and PD in a population characterized by a high prevalence of pesticide exposure. This case-control study was carried out among subjects enrolled in the Mutualite Sociale Agricole, the French health insurance organization for workers connected to the agricultural world. We included 247 cases and 676 controls matched on age, sex, and region of residency. Information on smoking was obtained through in-person interviews. Pesticide exposure was assessed using a case-by-case expert evaluation procedure. We found an inverse relationship between ever cigarette smoking and PD (odds ratio [OR] = 0.6; 95% confidence interval [CI] = 0.4-0.9). The strength of this association increased with the number of pack-years. This relationship was present even when smoking was considered as long as 40 years before PD onset. An inverse association was also present among subjects professionally exposed to pesticides (OR = 0.5; 95% CI = 0.3-0.8) and was independent of the duration of exposure among men. We confirm the inverse association between cigarette smoking and PD in a population characterized by a high prevalence of professional pesticide exposure. The relationship between PD and cigarette smoking was not significantly modified or confounded by exposure to pesticides. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/15468111/Cigarette_smoking_and_Parkinson's_disease:_a_case_control_study_in_a_population_characterized_by_a_high_prevalence_of_pesticide_exposure_ L2 - https://doi.org/10.1002/mds.20307 DB - PRIME DP - Unbound Medicine ER -