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Changes in DRG neurons and spinal excitability in neuropathy.
Novartis Found Symp. 2004; 261:103-10; discussion 110-5, 149-54.NF

Abstract

An intracellular signalling pathway in the dorsal root ganglion (DRG) and spinal neurons is a popular target in pain research that is relevant to the neuroplastic changes that occur during chronic pain conditions. First, we examined the phosphorylation of ERK in DRG neurons after peripheral inflammation and sciatic nerve transection without any stimulation to the receptive field. We found an activation of ERK in different populations of DRG neurons after peripheral inflammation and axotomy, which developed from alterations in target-derived nerve growth factor (NGF). We observed that the ERK signalling regulates the brain-derived neurotrophic factor (BDNF) expression in DRG neurons in both conditions. We also demonstrated that very rapid phosphorylation of ERK occurred in DRG neurons that were involved in the transmission of various noxious signals under normal conditions. Further, we examined the pERK labelling after the mechanical stimuli into the inflamed tissue and found that the pERK labelling occurred through the P2X3 receptors in the terminals. This activity-dependent activation of the ERK signal pathway may be useful for identifying which DRG neurons are involved in transmission of noxious stimuli under normal and pathological conditions.

Authors+Show Affiliations

Hyogo College of Medicine, Department of Anatomy and Neuroscience, Nishinomiya, Hyogo 663-8501, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15469046

Citation

Noguchi, Koichi, et al. "Changes in DRG Neurons and Spinal Excitability in Neuropathy." Novartis Foundation Symposium, vol. 261, 2004, pp. 103-10; discussion 110-5, 149-54.
Noguchi K, Obata K, Dai Y. Changes in DRG neurons and spinal excitability in neuropathy. Novartis Found Symp. 2004;261:103-10; discussion 110-5, 149-54.
Noguchi, K., Obata, K., & Dai, Y. (2004). Changes in DRG neurons and spinal excitability in neuropathy. Novartis Foundation Symposium, 261, 103-10; discussion 110-5, 149-54.
Noguchi K, Obata K, Dai Y. Changes in DRG Neurons and Spinal Excitability in Neuropathy. Novartis Found Symp. 2004;261:103-10; discussion 110-5, 149-54. PubMed PMID: 15469046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in DRG neurons and spinal excitability in neuropathy. AU - Noguchi,Koichi, AU - Obata,Koichi, AU - Dai,Yi, PY - 2004/10/8/pubmed PY - 2004/11/13/medline PY - 2004/10/8/entrez SP - 103-10; discussion 110-5, 149-54 JF - Novartis Foundation symposium JO - Novartis Found. Symp. VL - 261 N2 - An intracellular signalling pathway in the dorsal root ganglion (DRG) and spinal neurons is a popular target in pain research that is relevant to the neuroplastic changes that occur during chronic pain conditions. First, we examined the phosphorylation of ERK in DRG neurons after peripheral inflammation and sciatic nerve transection without any stimulation to the receptive field. We found an activation of ERK in different populations of DRG neurons after peripheral inflammation and axotomy, which developed from alterations in target-derived nerve growth factor (NGF). We observed that the ERK signalling regulates the brain-derived neurotrophic factor (BDNF) expression in DRG neurons in both conditions. We also demonstrated that very rapid phosphorylation of ERK occurred in DRG neurons that were involved in the transmission of various noxious signals under normal conditions. Further, we examined the pERK labelling after the mechanical stimuli into the inflamed tissue and found that the pERK labelling occurred through the P2X3 receptors in the terminals. This activity-dependent activation of the ERK signal pathway may be useful for identifying which DRG neurons are involved in transmission of noxious stimuli under normal and pathological conditions. SN - 1528-2511 UR - https://www.unboundmedicine.com/medline/citation/15469046/Changes_in_DRG_neurons_and_spinal_excitability_in_neuropathy_ DB - PRIME DP - Unbound Medicine ER -