Tags

Type your tag names separated by a space and hit enter

Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjects.
Br J Nutr. 2004 Sep; 92(3):477-83.BJ

Abstract

High doses of n-3 PUFA found in fish oils can reduce the circulating concentration of triacylglycerol (TG), which may contribute to the positive impact of these fatty acids on the risk of CVD. The present study aimed to establish the differential impact of EPA and docosahexaenoic (DHA) on plasma lipids and apo in adults. Forty-two normolipidaemic adult subjects completed a double-blind placebo controlled parallel study, receiving an EPA-rich oil (4.8 g EPA/d), DHA-rich oil (4.9 g DHA/d) or olive oil as control, for a period of 4 weeks. No effects of treatment on total cholesterol, LDL-cholesterol or HDL-cholesterol were evident. There was a significant 22 % reduction in TG level relative to the control value following the DHA treatment (P=0.032), with the 15 % decrease in the EPA group failing to reach significance (P=0.258). There were no significant inter-group differences in response to treatment for plasma apoA1, -C3 or -E levels, although a significant 15 % within-group increase in apoE was evident in the EPA (P=0.006) and DHA (P=0.003) groups. In addition, a within-group decrease in the apoA1:HDL-cholesterol ratio was observed in the DHA group, suggesting a positive impact of DHA on HDL particle size. The DHA intervention resulted in a significant increase in the proportion of EPA P=0.000 and DHA P=0.000 in plasma phospholipids, whilst significant increases in EPA P=0.000 and docosapentaenoic acid P=0.002, but not DHA P=0.193, were evident following EPA supplementation (P<0.05). Our present results indicate that DHA may be more efficacious than EPA in improving the plasma lipid profile.

Authors+Show Affiliations

Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15469651

Citation

Buckley, Richard, et al. "Circulating Triacylglycerol and apoE Levels in Response to EPA and Docosahexaenoic Acid Supplementation in Adult Human Subjects." The British Journal of Nutrition, vol. 92, no. 3, 2004, pp. 477-83.
Buckley R, Shewring B, Turner R, et al. Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjects. Br J Nutr. 2004;92(3):477-83.
Buckley, R., Shewring, B., Turner, R., Yaqoob, P., & Minihane, A. M. (2004). Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjects. The British Journal of Nutrition, 92(3), 477-83.
Buckley R, et al. Circulating Triacylglycerol and apoE Levels in Response to EPA and Docosahexaenoic Acid Supplementation in Adult Human Subjects. Br J Nutr. 2004;92(3):477-83. PubMed PMID: 15469651.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating triacylglycerol and apoE levels in response to EPA and docosahexaenoic acid supplementation in adult human subjects. AU - Buckley,Richard, AU - Shewring,Bethan, AU - Turner,Rufus, AU - Yaqoob,Parveen, AU - Minihane,Anne M, PY - 2004/10/8/pubmed PY - 2004/11/2/medline PY - 2004/10/8/entrez SP - 477 EP - 83 JF - The British journal of nutrition JO - Br J Nutr VL - 92 IS - 3 N2 - High doses of n-3 PUFA found in fish oils can reduce the circulating concentration of triacylglycerol (TG), which may contribute to the positive impact of these fatty acids on the risk of CVD. The present study aimed to establish the differential impact of EPA and docosahexaenoic (DHA) on plasma lipids and apo in adults. Forty-two normolipidaemic adult subjects completed a double-blind placebo controlled parallel study, receiving an EPA-rich oil (4.8 g EPA/d), DHA-rich oil (4.9 g DHA/d) or olive oil as control, for a period of 4 weeks. No effects of treatment on total cholesterol, LDL-cholesterol or HDL-cholesterol were evident. There was a significant 22 % reduction in TG level relative to the control value following the DHA treatment (P=0.032), with the 15 % decrease in the EPA group failing to reach significance (P=0.258). There were no significant inter-group differences in response to treatment for plasma apoA1, -C3 or -E levels, although a significant 15 % within-group increase in apoE was evident in the EPA (P=0.006) and DHA (P=0.003) groups. In addition, a within-group decrease in the apoA1:HDL-cholesterol ratio was observed in the DHA group, suggesting a positive impact of DHA on HDL particle size. The DHA intervention resulted in a significant increase in the proportion of EPA P=0.000 and DHA P=0.000 in plasma phospholipids, whilst significant increases in EPA P=0.000 and docosapentaenoic acid P=0.002, but not DHA P=0.193, were evident following EPA supplementation (P<0.05). Our present results indicate that DHA may be more efficacious than EPA in improving the plasma lipid profile. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/15469651/Circulating_triacylglycerol_and_apoE_levels_in_response_to_EPA_and_docosahexaenoic_acid_supplementation_in_adult_human_subjects_ L2 - https://www.cambridge.org/core/product/identifier/S0007114504001928/type/journal_article DB - PRIME DP - Unbound Medicine ER -