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Prevalence in a Tunisian Arabic population of factor VII DNA variants and relation to factor VII plasma levels.
Clin Chim Acta. 2004 Nov; 349(1-2):199-202.CC

Abstract

BACKGROUND

A raised plasma factor VII (FVII) level is a risk factor for coronary heart disease. DNA variants have been described to be associated with alteration in FVII levels. The prevalence of FVII polymorphisms is unknown in the Tunisian Arab population.

METHODS

In a group of 240 healthy Tunisians, we examined the relationship between levels of FVII coagulant activity (FVIIc) and two polymorphisms in the FVII gene. One polymorphism alters arginine at position 353 to glutamine (R/Q) and the other is a 10 base pair insertion (0/10 bp).

RESULTS

The FVII distribution was in accordance with the Hardy-Weinberg equilibrium. The allele frequencies of Q and 10 bp were 0.212 and 0.235, respectively. There were significant differences in these allelic frequencies between Tunisian and other populations (p<0.001). We observed lower FVIIc levels among subjects with the Q allele compared to RR subjects (RR: 98.17%, RQ/QQ: 57.41%, p<0.0001). For the 0/10 polymorphism, no statistically difference was observed.

CONCLUSION

The prevalence of the Q allele which was found to be associated with lower plasma FVIIc levels is high in Tunisian population. Further analyses should yield information on the protective role of carrying the Q allele for coronary heart disease.

Authors+Show Affiliations

Faculty of Medicine, 99-UR/08-39, Monastir, Tunisia. mednour@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15469874

Citation

Nour, Mohamed, et al. "Prevalence in a Tunisian Arabic Population of Factor VII DNA Variants and Relation to Factor VII Plasma Levels." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 349, no. 1-2, 2004, pp. 199-202.
Nour M, Slama FB, Monastiri K, et al. Prevalence in a Tunisian Arabic population of factor VII DNA variants and relation to factor VII plasma levels. Clin Chim Acta. 2004;349(1-2):199-202.
Nour, M., Slama, F. B., Monastiri, K., Hammami, M., & Helal, A. N. (2004). Prevalence in a Tunisian Arabic population of factor VII DNA variants and relation to factor VII plasma levels. Clinica Chimica Acta; International Journal of Clinical Chemistry, 349(1-2), 199-202.
Nour M, et al. Prevalence in a Tunisian Arabic Population of Factor VII DNA Variants and Relation to Factor VII Plasma Levels. Clin Chim Acta. 2004;349(1-2):199-202. PubMed PMID: 15469874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence in a Tunisian Arabic population of factor VII DNA variants and relation to factor VII plasma levels. AU - Nour,Mohamed, AU - Slama,Foued Belhaj, AU - Monastiri,Kamel, AU - Hammami,Mohamed, AU - Helal,Ahmed Noureddine, PY - 2004/06/10/received PY - 2004/06/24/revised PY - 2004/06/24/accepted PY - 2004/10/8/pubmed PY - 2005/3/2/medline PY - 2004/10/8/entrez SP - 199 EP - 202 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 349 IS - 1-2 N2 - BACKGROUND: A raised plasma factor VII (FVII) level is a risk factor for coronary heart disease. DNA variants have been described to be associated with alteration in FVII levels. The prevalence of FVII polymorphisms is unknown in the Tunisian Arab population. METHODS: In a group of 240 healthy Tunisians, we examined the relationship between levels of FVII coagulant activity (FVIIc) and two polymorphisms in the FVII gene. One polymorphism alters arginine at position 353 to glutamine (R/Q) and the other is a 10 base pair insertion (0/10 bp). RESULTS: The FVII distribution was in accordance with the Hardy-Weinberg equilibrium. The allele frequencies of Q and 10 bp were 0.212 and 0.235, respectively. There were significant differences in these allelic frequencies between Tunisian and other populations (p<0.001). We observed lower FVIIc levels among subjects with the Q allele compared to RR subjects (RR: 98.17%, RQ/QQ: 57.41%, p<0.0001). For the 0/10 polymorphism, no statistically difference was observed. CONCLUSION: The prevalence of the Q allele which was found to be associated with lower plasma FVIIc levels is high in Tunisian population. Further analyses should yield information on the protective role of carrying the Q allele for coronary heart disease. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/15469874/Prevalence_in_a_Tunisian_Arabic_population_of_factor_VII_DNA_variants_and_relation_to_factor_VII_plasma_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(04)00358-4 DB - PRIME DP - Unbound Medicine ER -