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T2-weighted MRI in Parkinson's disease; substantia nigra pars compacta hypointensity correlates with the clinical scores.
Neurol India. 2004 Sep; 52(3):332-7.NI

Abstract

BACKGROUND

Iron accumulation in substantia nigra pars compacta (SNpc) and related intensity and volumetric changes in patients with idiopathic Parkinson's disease (PD) has been reported previously. There are only a few studies evaluating the relation between neuroradiological findings and clinical scores, with contradictory results.

AIMS

In this study we aimed to measure the iron-rich brain areas of PD patients and healthy subjects with T2-weighted magnetic resonance imaging (MRI) and to evaluate the relation between the clinical scores of PD patients and these imaging results.

METHODS AND MATERIALS

T2-weighted MRI findings were studied in 20 patients with PD and 16 healthy controls. The width of SNpc, putamen volume, and the intensity of the basal ganglia were measured. Unified Parkinson's Disease Rating Scale (UPDRS) was used for evaluating the clinical status.

STATISTICAL ANALYSES

Mann Whitney U test for group comparisons, Wilcoxon sign rank test for comparisons within the patient group, and Spearman's rank correlation coefficient for analyses of correlations were used.

RESULTS

Mean SNpc and dentate nucleus intensities were lower in PD patients than healthy subjects. Mean SNpc width and putamen volumes were lower in patients. Decrease in the intensity of mean SNpc correlated with high UPDRS and rigidity scores.

CONCLUSION

The results of our study reflect the increase in iron accumulation and oxidative stress in the SNpc in Parkinson's disease. The decrease in the intensity of SNpc correlates with poor clinical scores.

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Authors+Show Affiliations

Atasoy HT
Zonguldak Karaelmas University, Faculty of Medicine Neurology Department, Turkey. htrlatasoy@hotmail.com.
Nuyan O
No affiliation info available
Tunc T
No affiliation info available
Yorubulut M
No affiliation info available
Unal AE
No affiliation info available
Inan LE
No affiliation info available

MeSH

AgedBrain ChemistryFemaleHumansIronMagnetic Resonance ImagingMaleMiddle AgedNeurologic ExaminationNeuropsychological TestsParkinson DiseaseProspective StudiesSubstantia Nigra

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15472421

Citation

Atasoy, Huseyin Tugrul, et al. "T2-weighted MRI in Parkinson's Disease; Substantia Nigra Pars Compacta Hypointensity Correlates With the Clinical Scores." Neurology India, vol. 52, no. 3, 2004, pp. 332-7.
Atasoy HT, Nuyan O, Tunc T, et al. T2-weighted MRI in Parkinson's disease; substantia nigra pars compacta hypointensity correlates with the clinical scores. Neurol India. 2004;52(3):332-7.
Atasoy, H. T., Nuyan, O., Tunc, T., Yorubulut, M., Unal, A. E., & Inan, L. E. (2004). T2-weighted MRI in Parkinson's disease; substantia nigra pars compacta hypointensity correlates with the clinical scores. Neurology India, 52(3), 332-7.
Atasoy HT, et al. T2-weighted MRI in Parkinson's Disease; Substantia Nigra Pars Compacta Hypointensity Correlates With the Clinical Scores. Neurol India. 2004;52(3):332-7. PubMed PMID: 15472421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - T2-weighted MRI in Parkinson's disease; substantia nigra pars compacta hypointensity correlates with the clinical scores. AU - Atasoy,Huseyin Tugrul, AU - Nuyan,Oguz, AU - Tunc,Tugba, AU - Yorubulut,Mehmet, AU - Unal,Aysun E, AU - Inan,Levent E, PY - 2004/10/9/pubmed PY - 2004/12/16/medline PY - 2004/10/9/entrez SP - 332 EP - 7 JF - Neurology India JO - Neurol India VL - 52 IS - 3 N2 - BACKGROUND: Iron accumulation in substantia nigra pars compacta (SNpc) and related intensity and volumetric changes in patients with idiopathic Parkinson's disease (PD) has been reported previously. There are only a few studies evaluating the relation between neuroradiological findings and clinical scores, with contradictory results. AIMS: In this study we aimed to measure the iron-rich brain areas of PD patients and healthy subjects with T2-weighted magnetic resonance imaging (MRI) and to evaluate the relation between the clinical scores of PD patients and these imaging results. METHODS AND MATERIALS: T2-weighted MRI findings were studied in 20 patients with PD and 16 healthy controls. The width of SNpc, putamen volume, and the intensity of the basal ganglia were measured. Unified Parkinson's Disease Rating Scale (UPDRS) was used for evaluating the clinical status. STATISTICAL ANALYSES: Mann Whitney U test for group comparisons, Wilcoxon sign rank test for comparisons within the patient group, and Spearman's rank correlation coefficient for analyses of correlations were used. RESULTS: Mean SNpc and dentate nucleus intensities were lower in PD patients than healthy subjects. Mean SNpc width and putamen volumes were lower in patients. Decrease in the intensity of mean SNpc correlated with high UPDRS and rigidity scores. CONCLUSION: The results of our study reflect the increase in iron accumulation and oxidative stress in the SNpc in Parkinson's disease. The decrease in the intensity of SNpc correlates with poor clinical scores. SN - 0028-3886 UR - https://www.unboundmedicine.com/medline/citation/15472421/T2_weighted_MRI_in_Parkinson's_disease L2 - http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2004;volume=52;issue=3;spage=332;epage=337;aulast=Atasoy DB - PRIME DP - Unbound Medicine ER -