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Nasopharyngeal pneumococcal carriage after combined pneumococcal conjugate and polysaccharide vaccination in children with a history of recurrent acute otitis media.
Clin Infect Dis 2004; 39(7):911-9CI

Abstract

BACKGROUND

We recently showed that vaccination with a 7-valent pneumococcal conjugate vaccine (PCV7) followed by a 23-valent pneumococcal polysaccharide vaccine (PPSV23) failed to prevent new episodes of acute otitis media (AOM) in previously unvaccinated toddlers and children with a history of recurrent AOM. We describe in detail the impact of pneumococcal vaccinations on nasopharyngeal carriage of S. pneumoniae in this study population.

METHODS

The impact of vaccination with PCV7 followed by PPSV23 on pneumococcal nasopharyngeal carriage was studied in a prospective, randomized trial involving 383 children (age range, 1-7 years) with previous AOM. Nasopharyngeal swab specimens were collected at the time of first vaccination and at 6-7-month intervals during the 26-month follow-up period.

RESULTS

Overall, pneumococcal carriage rates did not diminish, remaining at approximately 50% in both PCV7/PPSV23 and control vaccinees. A significant shift from conjugate vaccine- to nonconjugate vaccine-type pneumococci was observed in children aged 1-2 years, who received the conjugate vaccine twice before the polysaccharide vaccine was administered. Conjugate vaccine serotype carriage was not influenced in older children, who received the conjugate vaccine once before receiving the polysaccharide booster.

CONCLUSIONS

The administration of conjugate vaccines at least twice also after 2 years of age may be mandatory for reducing the carriage of conjugate vaccine serotypes in children with recurrent AOM. Polysaccharide booster vaccination did not affect nasopharyngeal colonization with serotypes not included in the conjugate vaccine.

Authors+Show Affiliations

Department of Pediatrics, Spaarne Hospital, Haarlem, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15472839

Citation

Veenhoven, Reinier H., et al. "Nasopharyngeal Pneumococcal Carriage After Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Children With a History of Recurrent Acute Otitis Media." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 39, no. 7, 2004, pp. 911-9.
Veenhoven RH, Bogaert D, Schilder AG, et al. Nasopharyngeal pneumococcal carriage after combined pneumococcal conjugate and polysaccharide vaccination in children with a history of recurrent acute otitis media. Clin Infect Dis. 2004;39(7):911-9.
Veenhoven, R. H., Bogaert, D., Schilder, A. G., Rijkers, G. T., Uiterwaal, C. S., Kiezebrink, H. H., ... Sanders, E. A. (2004). Nasopharyngeal pneumococcal carriage after combined pneumococcal conjugate and polysaccharide vaccination in children with a history of recurrent acute otitis media. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 39(7), pp. 911-9.
Veenhoven RH, et al. Nasopharyngeal Pneumococcal Carriage After Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Children With a History of Recurrent Acute Otitis Media. Clin Infect Dis. 2004 Oct 1;39(7):911-9. PubMed PMID: 15472839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasopharyngeal pneumococcal carriage after combined pneumococcal conjugate and polysaccharide vaccination in children with a history of recurrent acute otitis media. AU - Veenhoven,Reinier H, AU - Bogaert,Debby, AU - Schilder,Anne G M, AU - Rijkers,Ger T, AU - Uiterwaal,Cuno S P M, AU - Kiezebrink,Herma H, AU - van Kempen,Muriel J P, AU - Dhooge,Inge J, AU - Bruin,Jacob, AU - Ijzerman,Ed P F, AU - de Groot,Ronald, AU - Kuis,Wietse, AU - Hermans,Peter W M, AU - Sanders,Elisabeth A M, Y1 - 2004/09/01/ PY - 2004/01/29/received PY - 2004/03/31/accepted PY - 2004/10/9/pubmed PY - 2006/8/8/medline PY - 2004/10/9/entrez SP - 911 EP - 9 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 39 IS - 7 N2 - BACKGROUND: We recently showed that vaccination with a 7-valent pneumococcal conjugate vaccine (PCV7) followed by a 23-valent pneumococcal polysaccharide vaccine (PPSV23) failed to prevent new episodes of acute otitis media (AOM) in previously unvaccinated toddlers and children with a history of recurrent AOM. We describe in detail the impact of pneumococcal vaccinations on nasopharyngeal carriage of S. pneumoniae in this study population. METHODS: The impact of vaccination with PCV7 followed by PPSV23 on pneumococcal nasopharyngeal carriage was studied in a prospective, randomized trial involving 383 children (age range, 1-7 years) with previous AOM. Nasopharyngeal swab specimens were collected at the time of first vaccination and at 6-7-month intervals during the 26-month follow-up period. RESULTS: Overall, pneumococcal carriage rates did not diminish, remaining at approximately 50% in both PCV7/PPSV23 and control vaccinees. A significant shift from conjugate vaccine- to nonconjugate vaccine-type pneumococci was observed in children aged 1-2 years, who received the conjugate vaccine twice before the polysaccharide vaccine was administered. Conjugate vaccine serotype carriage was not influenced in older children, who received the conjugate vaccine once before receiving the polysaccharide booster. CONCLUSIONS: The administration of conjugate vaccines at least twice also after 2 years of age may be mandatory for reducing the carriage of conjugate vaccine serotypes in children with recurrent AOM. Polysaccharide booster vaccination did not affect nasopharyngeal colonization with serotypes not included in the conjugate vaccine. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/15472839/Nasopharyngeal_pneumococcal_carriage_after_combined_pneumococcal_conjugate_and_polysaccharide_vaccination_in_children_with_a_history_of_recurrent_acute_otitis_media_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/422651 DB - PRIME DP - Unbound Medicine ER -