Tags

Type your tag names separated by a space and hit enter

Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans.
Clin Endocrinol (Oxf). 2004 Oct; 61(4):503-9.CE

Abstract

OBJECTIVE

Circulating ghrelin levels are increased by fasting and decreased by feeding, glucose load, insulin and somatostatin. Whether hyperglycaemia and insulin directly inhibit ghrelin secretion still remains matter of debate. The aim of the present study was therefore to investigate further the regulatory effects of glucose and insulin on ghrelin secretion.

DESIGN AND SUBJECTS

We studied the effects of glucose [oral glucose tolerance test (OGTT) 100 g orally], insulin-induced hypoglycaemia [ITT, 0.1 IU/kg insulin intravenously (i.v.)], glucagon (1 mg i.v.), arginine (0.5 mg/kg i.v.) and saline on ghrelin, GH, insulin, glucose and glucagon levels in six normal subjects.

MEASUREMENTS

In all the sessions, blood samples were collected every 15 min from 0 up to + 120 min. Ghrelin, GH, insulin, glucagon and glucose levels were assayed at each time point.

RESULTS

OGTT increased (P < 0.01) glucose and insulin while decreasing (P < 0.01) GH and ghrelin levels. ITT increased (P < 0.01) GH but decreased (P < 0.01) ghrelin levels. Glucagon increased (P < 0.01) glucose and insulin without modifying GH and ghrelin. Arginine increased (P < 0.01) GH, insulin, glucagon and glucose (P < 0.05) but did not affect ghrelin secretion.

CONCLUSIONS

Ghrelin secretion in humans is inhibited by OGTT-induced hyperglycaemia and ITT but not by glucagon and arginine, two substances able to increase insulin and glucose levels. These findings question the assumption that glucose and insulin directly regulate ghrelin secretion. On the other hand, ghrelin secretion is not associated with the GH response to ITT or arginine, indicating that the somatotroph response to these stimuli is unlikely to be mediated by ghrelin.

Authors+Show Affiliations

Division of Endocrinology, Department of Internal Medicine, Erasmus University of Rotterdam, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15473884

Citation

Broglio, Fabio, et al. "Ghrelin Secretion Is Inhibited By Glucose Load and Insulin-induced Hypoglycaemia but Unaffected By Glucagon and Arginine in Humans." Clinical Endocrinology, vol. 61, no. 4, 2004, pp. 503-9.
Broglio F, Gottero C, Prodam F, et al. Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans. Clin Endocrinol (Oxf). 2004;61(4):503-9.
Broglio, F., Gottero, C., Prodam, F., Destefanis, S., Gauna, C., Me, E., Riganti, F., Vivenza, D., Rapa, A., Martina, V., Arvat, E., Bona, G., van der Lely, A. J., & Ghigo, E. (2004). Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans. Clinical Endocrinology, 61(4), 503-9.
Broglio F, et al. Ghrelin Secretion Is Inhibited By Glucose Load and Insulin-induced Hypoglycaemia but Unaffected By Glucagon and Arginine in Humans. Clin Endocrinol (Oxf). 2004;61(4):503-9. PubMed PMID: 15473884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans. AU - Broglio,Fabio, AU - Gottero,Cristina, AU - Prodam,Flavia, AU - Destefanis,Silvia, AU - Gauna,Carlotta, AU - Me,Elisa, AU - Riganti,Fabrizio, AU - Vivenza,Daniela, AU - Rapa,Anna, AU - Martina,Valentino, AU - Arvat,Emanuela, AU - Bona,Gianni, AU - van der Lely,Aart Jan, AU - Ghigo,Ezio, PY - 2004/10/12/pubmed PY - 2005/3/2/medline PY - 2004/10/12/entrez SP - 503 EP - 9 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 61 IS - 4 N2 - OBJECTIVE: Circulating ghrelin levels are increased by fasting and decreased by feeding, glucose load, insulin and somatostatin. Whether hyperglycaemia and insulin directly inhibit ghrelin secretion still remains matter of debate. The aim of the present study was therefore to investigate further the regulatory effects of glucose and insulin on ghrelin secretion. DESIGN AND SUBJECTS: We studied the effects of glucose [oral glucose tolerance test (OGTT) 100 g orally], insulin-induced hypoglycaemia [ITT, 0.1 IU/kg insulin intravenously (i.v.)], glucagon (1 mg i.v.), arginine (0.5 mg/kg i.v.) and saline on ghrelin, GH, insulin, glucose and glucagon levels in six normal subjects. MEASUREMENTS: In all the sessions, blood samples were collected every 15 min from 0 up to + 120 min. Ghrelin, GH, insulin, glucagon and glucose levels were assayed at each time point. RESULTS: OGTT increased (P < 0.01) glucose and insulin while decreasing (P < 0.01) GH and ghrelin levels. ITT increased (P < 0.01) GH but decreased (P < 0.01) ghrelin levels. Glucagon increased (P < 0.01) glucose and insulin without modifying GH and ghrelin. Arginine increased (P < 0.01) GH, insulin, glucagon and glucose (P < 0.05) but did not affect ghrelin secretion. CONCLUSIONS: Ghrelin secretion in humans is inhibited by OGTT-induced hyperglycaemia and ITT but not by glucagon and arginine, two substances able to increase insulin and glucose levels. These findings question the assumption that glucose and insulin directly regulate ghrelin secretion. On the other hand, ghrelin secretion is not associated with the GH response to ITT or arginine, indicating that the somatotroph response to these stimuli is unlikely to be mediated by ghrelin. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/15473884/Ghrelin_secretion_is_inhibited_by_glucose_load_and_insulin_induced_hypoglycaemia_but_unaffected_by_glucagon_and_arginine_in_humans_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0300-0664&amp;date=2004&amp;volume=61&amp;issue=4&amp;spage=503 DB - PRIME DP - Unbound Medicine ER -