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[Detection of FLT3 gene and FLT3/ITD gene mutation in chronic myeloid leukemia and its significance].
Ai Zheng. 2004 Oct; 23(10):1218-21.AZ

Abstract

BACKGROUND & OBJECTIVE

Fms-like tyrosine kinase 3 (FLT3)gene abnormal expression could be detected in most of acute myeloid leukemia (AML)patients, and 20%-30% of them have FLT3/ITD gene mutation which indicate poor prognosis. This study was to detect FLT3 gene expression, and FLT3/ITD gene mutation in chronic myeloid leukemia (CML)patients, and analyze their relationships with prognosis.

METHODS

Polymerase chain reaction (PCR)was used to detect FLT3 gene expression, and FLT3/ITD gene mutation in 53 CML patients of chronic phase,and 34 CML patients of accelerated phase or blast crisis.

RESULTS

FLT3 gene was detected in 5.7%(3/53)CML patients of chronic phase, and in 55.9% (19/34)CML patients of accelerated phase or blast crisis,the difference of FLT3 gene positive rate between these 2 groups was significant (P< 0.001). Only 2 of 87 CML patients (2.3%)were found with FLT3/ITD mutation.

CONCLUSIONS

FTL3 gene expresses mainly in CML patients of accelerated phase or blast crisis. FTL3/ITD gene mutation was seldom involved in CML patients. The CML patients with FLT3 gene expression and FTL3/ITD gene mutation may have poor prognosis.

Authors+Show Affiliations

Xu B
Department of Hematology, Nanfang Hospital, The First Military Medical University, Guangzhou, Guangdong, 510515, P.R.China. xbzj@fimmu.edu.com
Tian H
No affiliation info available
Zhou SY
No affiliation info available

MeSH

AdultAgedBlast CrisisFemaleHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, Accelerated PhaseMaleMiddle AgedMutationPrognosisProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesTandem Repeat Sequencesfms-Like Tyrosine Kinase 3

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15473940

Citation

Xu, Bing, et al. "[Detection of FLT3 Gene and FLT3/ITD Gene Mutation in Chronic Myeloid Leukemia and Its Significance]." Ai Zheng = Aizheng = Chinese Journal of Cancer, vol. 23, no. 10, 2004, pp. 1218-21.
Xu B, Tian H, Zhou SY. [Detection of FLT3 gene and FLT3/ITD gene mutation in chronic myeloid leukemia and its significance]. Ai Zheng. 2004;23(10):1218-21.
Xu, B., Tian, H., & Zhou, S. Y. (2004). [Detection of FLT3 gene and FLT3/ITD gene mutation in chronic myeloid leukemia and its significance]. Ai Zheng = Aizheng = Chinese Journal of Cancer, 23(10), 1218-21.
Xu B, Tian H, Zhou SY. [Detection of FLT3 Gene and FLT3/ITD Gene Mutation in Chronic Myeloid Leukemia and Its Significance]. Ai Zheng. 2004;23(10):1218-21. PubMed PMID: 15473940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Detection of FLT3 gene and FLT3/ITD gene mutation in chronic myeloid leukemia and its significance]. AU - Xu,Bing, AU - Tian,Hong, AU - Zhou,Shu-Yun, PY - 2004/10/12/pubmed PY - 2005/8/16/medline PY - 2004/10/12/entrez SP - 1218 EP - 21 JF - Ai zheng = Aizheng = Chinese journal of cancer JO - Ai Zheng VL - 23 IS - 10 N2 - BACKGROUND & OBJECTIVE: Fms-like tyrosine kinase 3 (FLT3)gene abnormal expression could be detected in most of acute myeloid leukemia (AML)patients, and 20%-30% of them have FLT3/ITD gene mutation which indicate poor prognosis. This study was to detect FLT3 gene expression, and FLT3/ITD gene mutation in chronic myeloid leukemia (CML)patients, and analyze their relationships with prognosis. METHODS: Polymerase chain reaction (PCR)was used to detect FLT3 gene expression, and FLT3/ITD gene mutation in 53 CML patients of chronic phase,and 34 CML patients of accelerated phase or blast crisis. RESULTS: FLT3 gene was detected in 5.7%(3/53)CML patients of chronic phase, and in 55.9% (19/34)CML patients of accelerated phase or blast crisis,the difference of FLT3 gene positive rate between these 2 groups was significant (P< 0.001). Only 2 of 87 CML patients (2.3%)were found with FLT3/ITD mutation. CONCLUSIONS: FTL3 gene expresses mainly in CML patients of accelerated phase or blast crisis. FTL3/ITD gene mutation was seldom involved in CML patients. The CML patients with FLT3 gene expression and FTL3/ITD gene mutation may have poor prognosis. UR - https://www.unboundmedicine.com/medline/citation/15473940/[Detection_of_FLT3_gene_and_FLT3/ITD_gene_mutation_in_chronic_myeloid_leukemia_and_its_significance]_ DB - PRIME DP - Unbound Medicine ER -