Tags

Type your tag names separated by a space and hit enter

Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium.
Fertil Steril. 2004 Oct; 82 Suppl 3:1182-7.FS

Abstract

OBJECTIVE

To examine the ultrastructural characteristics of extracellular matrix and mature collagen fibrils in uterine leiomyomas and compare them with those in adjacent normal myometrium.

DESIGN

Analysis of paired leiomyoma-myometrium in surgical specimens.

SETTING

Research center and tertiary care center.

SUBJECT(S)

Women undergoing medically indicated hysterectomy for symptomatic uterine leiomyomas.

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

Appearance and spatial orientation of the collagen fibrils in leiomyomas compared with myometrium.

RESULT(S)

Observation of specimens at x 12,500 magnification indicated that collagen fibrils were more abundant, loosely packed, and arrayed in a nonparallel manner in leiomyomas compared with myometrium. Random areas were examined at x 6,500 to x 64,000 magnification and revealed collagen fibrils of equal diameter in both leiomyomas and myometrium. However, an ordered and regular barbed appearance was present in collagen fibrils from myometrium but was lacking in leiomyomas.

CONCLUSION(S)

Leiomyomas contain an abnormal collagen fibril structure and orientation, which suggests that the well-regulated fibril formation in myometrium is altered in leiomyomas. Alterations in collagen genes may play a role in the pathogenesis of leiomyomas.

Links

PMC Free PDF

Authors+Show Affiliations

Leppert PC
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA. leppertp@mail.nih.gov
Baginski T
No affiliation info available
Prupas C
No affiliation info available
Catherino WH
No affiliation info available
Pletcher S
No affiliation info available
Segars JH
No affiliation info available

MeSH

AdultFemaleFibrillar CollagensHumansLeiomyomaMiddle AgedMyometriumUterine Neoplasms

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15474093

Citation

Leppert, Phyllis C., et al. "Comparative Ultrastructure of Collagen Fibrils in Uterine Leiomyomas and Normal Myometrium." Fertility and Sterility, vol. 82 Suppl 3, 2004, pp. 1182-7.
Leppert PC, Baginski T, Prupas C, et al. Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium. Fertil Steril. 2004;82 Suppl 3:1182-7.
Leppert, P. C., Baginski, T., Prupas, C., Catherino, W. H., Pletcher, S., & Segars, J. H. (2004). Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium. Fertility and Sterility, 82 Suppl 3, 1182-7.
Leppert PC, et al. Comparative Ultrastructure of Collagen Fibrils in Uterine Leiomyomas and Normal Myometrium. Fertil Steril. 2004;82 Suppl 3:1182-7. PubMed PMID: 15474093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium. AU - Leppert,Phyllis C, AU - Baginski,Thomas, AU - Prupas,Cara, AU - Catherino,William H, AU - Pletcher,Susan, AU - Segars,James H, PY - 2003/12/30/received PY - 2004/04/01/revised PY - 2004/04/01/accepted PY - 2004/10/12/pubmed PY - 2004/12/16/medline PY - 2004/10/12/entrez SP - 1182 EP - 7 JF - Fertility and sterility JO - Fertil Steril VL - 82 Suppl 3 N2 - OBJECTIVE: To examine the ultrastructural characteristics of extracellular matrix and mature collagen fibrils in uterine leiomyomas and compare them with those in adjacent normal myometrium. DESIGN: Analysis of paired leiomyoma-myometrium in surgical specimens. SETTING: Research center and tertiary care center. SUBJECT(S): Women undergoing medically indicated hysterectomy for symptomatic uterine leiomyomas. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Appearance and spatial orientation of the collagen fibrils in leiomyomas compared with myometrium. RESULT(S): Observation of specimens at x 12,500 magnification indicated that collagen fibrils were more abundant, loosely packed, and arrayed in a nonparallel manner in leiomyomas compared with myometrium. Random areas were examined at x 6,500 to x 64,000 magnification and revealed collagen fibrils of equal diameter in both leiomyomas and myometrium. However, an ordered and regular barbed appearance was present in collagen fibrils from myometrium but was lacking in leiomyomas. CONCLUSION(S): Leiomyomas contain an abnormal collagen fibril structure and orientation, which suggests that the well-regulated fibril formation in myometrium is altered in leiomyomas. Alterations in collagen genes may play a role in the pathogenesis of leiomyomas. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/15474093/Comparative_ultrastructure_of_collagen_fibrils_in_uterine_leiomyomas_and_normal_myometrium_ DB - PRIME DP - Unbound Medicine ER -