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ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure.
J Appl Physiol (1985). 2004 Nov; 97(5):1746-54.JA

Abstract

Chronic heart failure (CHF) is characterized by sympathoexcitation, and the cardiac sympathetic afferent reflex (CSAR) is a sympathoexcitatory reflex. Our previous studies have shown that the CSAR was enhanced in CHF. In addition, central angiotensin II (ANG II) is an important modulator of this reflex. This study was performed to determine whether the CSAR evoked by stimulation of cardiac sympathetic afferent nerves (CSAN) in rats with coronary ligation-induced CHF is enhanced by ANG II in the paraventricular nucleus (PVN). Under alpha-chloralose and urethane anesthesia, renal sympathetic nerve activity (RSNA) was recorded. The RSNA responses to electrical stimulation (5, 10, 20, and 30 Hz) of the CSAN were evaluated. Bilateral microinjection of the AT1-receptor antagonist losartan (50 nmol) into the PVN had no significant effects in the sham group, but it abolished the enhanced RSNA response to stimulation in the CHF group. Unilateral microinjection of three doses of ANG II (0.03, 0.3, and 3 nmol) into the PVN resulted in dose-related increases in the RSNA responses to stimulation. Although ANG II also potentiated the RSNA response to electrical stimulation in sham rats, the RSNA responses to stimulation after ANG II into the PVN in rats with CHF were much greater than in sham rats. The effects of ANG II were prevented by pretreatment with losartan into the PVN in CHF rats. These results suggest that the central gain of the CSAR is enhanced in rats with coronary ligation-induced CHF and that ANG II in the PVN augments the CSAR evoked by CSAN, which is mediated by the central angiotensin AT1 receptors in rats with CHF.

Authors+Show Affiliations

Department of Physiology, Nanjing Medical University, Nanjing 210029, Peoples Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15475555

Citation

Zhu, Guo-Qing, et al. "ANG II in the Paraventricular Nucleus Potentiates the Cardiac Sympathetic Afferent Reflex in Rats With Heart Failure." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 97, no. 5, 2004, pp. 1746-54.
Zhu GQ, Gao L, Patel KP, et al. ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure. J Appl Physiol (1985). 2004;97(5):1746-54.
Zhu, G. Q., Gao, L., Patel, K. P., Zucker, I. H., & Wang, W. (2004). ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure. Journal of Applied Physiology (Bethesda, Md. : 1985), 97(5), 1746-54.
Zhu GQ, et al. ANG II in the Paraventricular Nucleus Potentiates the Cardiac Sympathetic Afferent Reflex in Rats With Heart Failure. J Appl Physiol (1985). 2004;97(5):1746-54. PubMed PMID: 15475555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure. AU - Zhu,Guo-Qing, AU - Gao,Lie, AU - Patel,Kuashik P, AU - Zucker,Irving H, AU - Wang,Wei, PY - 2004/10/12/pubmed PY - 2005/2/26/medline PY - 2004/10/12/entrez SP - 1746 EP - 54 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 97 IS - 5 N2 - Chronic heart failure (CHF) is characterized by sympathoexcitation, and the cardiac sympathetic afferent reflex (CSAR) is a sympathoexcitatory reflex. Our previous studies have shown that the CSAR was enhanced in CHF. In addition, central angiotensin II (ANG II) is an important modulator of this reflex. This study was performed to determine whether the CSAR evoked by stimulation of cardiac sympathetic afferent nerves (CSAN) in rats with coronary ligation-induced CHF is enhanced by ANG II in the paraventricular nucleus (PVN). Under alpha-chloralose and urethane anesthesia, renal sympathetic nerve activity (RSNA) was recorded. The RSNA responses to electrical stimulation (5, 10, 20, and 30 Hz) of the CSAN were evaluated. Bilateral microinjection of the AT1-receptor antagonist losartan (50 nmol) into the PVN had no significant effects in the sham group, but it abolished the enhanced RSNA response to stimulation in the CHF group. Unilateral microinjection of three doses of ANG II (0.03, 0.3, and 3 nmol) into the PVN resulted in dose-related increases in the RSNA responses to stimulation. Although ANG II also potentiated the RSNA response to electrical stimulation in sham rats, the RSNA responses to stimulation after ANG II into the PVN in rats with CHF were much greater than in sham rats. The effects of ANG II were prevented by pretreatment with losartan into the PVN in CHF rats. These results suggest that the central gain of the CSAR is enhanced in rats with coronary ligation-induced CHF and that ANG II in the PVN augments the CSAR evoked by CSAN, which is mediated by the central angiotensin AT1 receptors in rats with CHF. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/15475555/ANG_II_in_the_paraventricular_nucleus_potentiates_the_cardiac_sympathetic_afferent_reflex_in_rats_with_heart_failure_ L2 - https://journals.physiology.org/doi/10.1152/japplphysiol.00573.2004?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -