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Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine.
J Cardiovasc Pharmacol. 2004 Sep; 44(3):302-9.JC

Abstract

The mechanisms involved in the cardioprotector effect of red wine have not yet been completely elucidated but probably an endothelium-dependent vasodilator action may play a significant role in this effect. Experiments were undertaken to determine whether a Brazilian red wine (BRW) induces vasodilation in the mesenteric vascular bed (MVB) and an antihypertensive effect was also assessed in rats with NO-deficient hypertension. In MVB precontracted with norepinephrine, BRW (alcohol-free lyophilized) induces a long-lasting endothelium-dependent vasodilation that is not reduced by indomethacin. Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) and guanylyl cyclase by 1H-[1,2,3] oxadiazolo [4,4-a]quinoxalin-1-one (ODQ) reduces the vasodilator effect of BRW. In vessels precontracted with norepinephrine and depolarized with KCl (25 Mm) or treated with Ca-dependent K channel blockers charybdotoxin (ChTx) plus apamin, the effect of BRW was significantly reduced. However, this effect is not affected by ATP-dependent K (KATP) channel blocker (glibenclamide). The residual vasodilator effect of BRW observed in vessels pretreated with ChTx plus apamin is completely abolished by ChTx plus apamin plus L-NAME. Concentrations of atropine, pyrilamine, yohimbine, and HOE 140 that significantly reduced the vasodilator effect of acetylcholine, histamine, clonidine, and bradykinin, respectively did not change the vasodilator effect of BRW. Chronic oral administration of BRW induced a significant reduction in systolic, mean and diastolic arterial pressure in rats with L-NAME hypertension. The present results demonstrated that vasodilator effect of BRW is dependent on endothelium-derived hyperpolarizing factor (EDHF) in combination with nitric oxide (NO). The antihypertensive effect of red wine demonstrated in the present study may play a significant role on the cardioprotective action of chronic red wine consumption.

Authors+Show Affiliations

Department of Pharmacology, State University of Rio de Janeiro, Rio de Janeiro, Brazil. demoura@uerj.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15475826

Citation

de Moura, Roberto Soares, et al. "Mechanism of the Endothelium-dependent Vasodilation and the Antihypertensive Effect of Brazilian Red Wine." Journal of Cardiovascular Pharmacology, vol. 44, no. 3, 2004, pp. 302-9.
de Moura RS, Miranda DZ, Pinto AC, et al. Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine. J Cardiovasc Pharmacol. 2004;44(3):302-9.
de Moura, R. S., Miranda, D. Z., Pinto, A. C., Sicca, R. F., Souza, M. A., Rubenich, L. M., Carvalho, L. C., Rangel, B. M., Tano, T., Madeira, S. V., & Resende, A. C. (2004). Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine. Journal of Cardiovascular Pharmacology, 44(3), 302-9.
de Moura RS, et al. Mechanism of the Endothelium-dependent Vasodilation and the Antihypertensive Effect of Brazilian Red Wine. J Cardiovasc Pharmacol. 2004;44(3):302-9. PubMed PMID: 15475826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine. AU - de Moura,Roberto Soares, AU - Miranda,Daniel Z, AU - Pinto,Ana Cláudia A, AU - Sicca,Raquel F, AU - Souza,Marcelo A V, AU - Rubenich,Lorna M S, AU - Carvalho,Lenize C R M, AU - Rangel,Bruno M, AU - Tano,Tania, AU - Madeira,Socorro V F, AU - Resende,Angela C, PY - 2004/10/12/pubmed PY - 2005/1/5/medline PY - 2004/10/12/entrez SP - 302 EP - 9 JF - Journal of cardiovascular pharmacology JO - J Cardiovasc Pharmacol VL - 44 IS - 3 N2 - The mechanisms involved in the cardioprotector effect of red wine have not yet been completely elucidated but probably an endothelium-dependent vasodilator action may play a significant role in this effect. Experiments were undertaken to determine whether a Brazilian red wine (BRW) induces vasodilation in the mesenteric vascular bed (MVB) and an antihypertensive effect was also assessed in rats with NO-deficient hypertension. In MVB precontracted with norepinephrine, BRW (alcohol-free lyophilized) induces a long-lasting endothelium-dependent vasodilation that is not reduced by indomethacin. Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) and guanylyl cyclase by 1H-[1,2,3] oxadiazolo [4,4-a]quinoxalin-1-one (ODQ) reduces the vasodilator effect of BRW. In vessels precontracted with norepinephrine and depolarized with KCl (25 Mm) or treated with Ca-dependent K channel blockers charybdotoxin (ChTx) plus apamin, the effect of BRW was significantly reduced. However, this effect is not affected by ATP-dependent K (KATP) channel blocker (glibenclamide). The residual vasodilator effect of BRW observed in vessels pretreated with ChTx plus apamin is completely abolished by ChTx plus apamin plus L-NAME. Concentrations of atropine, pyrilamine, yohimbine, and HOE 140 that significantly reduced the vasodilator effect of acetylcholine, histamine, clonidine, and bradykinin, respectively did not change the vasodilator effect of BRW. Chronic oral administration of BRW induced a significant reduction in systolic, mean and diastolic arterial pressure in rats with L-NAME hypertension. The present results demonstrated that vasodilator effect of BRW is dependent on endothelium-derived hyperpolarizing factor (EDHF) in combination with nitric oxide (NO). The antihypertensive effect of red wine demonstrated in the present study may play a significant role on the cardioprotective action of chronic red wine consumption. SN - 0160-2446 UR - https://www.unboundmedicine.com/medline/citation/15475826/Mechanism_of_the_endothelium_dependent_vasodilation_and_the_antihypertensive_effect_of_Brazilian_red_wine_ L2 - https://doi.org/10.1097/01.fjc.0000133060.10597.3c DB - PRIME DP - Unbound Medicine ER -