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Hyperphosphorylated tau protein in the cerebrospinal fluid of patients with Alzheimer's disease and other dementias: preliminary findings.
Arq Neuropsiquiatr 2004; 62(3B):751-5AN

Abstract

Alzheimer's disease (AD) is pathologically characterized by the accumulation of amyloid plaques and tau-associated neurofibrillary tangles in the cerebral tissue. The search for antemortem biomarkers is intense including analysis of cerebrospinal fluid (CSF) beta-amyloid and tau proteins concentrations seeking for an accurate and early diagnosis. Levels of hyperphosphorylated tau at threonine 181 were measured in the CSF of 34 patients with AD (19 with senile AD - SAD and eight with presenile AD - PSAD) and seven with other dementias (OD). The levels of CSF phosphotau were significantly higher in the AD patients compared to OD (AUC 0.812), with no association with severity of dementia, age of onset, duration of the disease or scores in the Mini-Mental State Examination. There were no differences of phosphotau levels between SAD and PSAD patients. These findings corroborate some previous studies and indicate that CSF phosphotau may help to differentiate AD from other dementias.

Authors+Show Affiliations

Department of Neurology, University of São Paulo School of Medicine, São Paulo SP, Brazil. aphartmann@uol.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15476062

Citation

Hartmann, Ana Paula Barbosa Jeronimo, et al. "Hyperphosphorylated Tau Protein in the Cerebrospinal Fluid of Patients With Alzheimer's Disease and Other Dementias: Preliminary Findings." Arquivos De Neuro-psiquiatria, vol. 62, no. 3B, 2004, pp. 751-5.
Hartmann AP, Almeida SM, Livramento JA, et al. Hyperphosphorylated tau protein in the cerebrospinal fluid of patients with Alzheimer's disease and other dementias: preliminary findings. Arq Neuropsiquiatr. 2004;62(3B):751-5.
Hartmann, A. P., Almeida, S. M., Livramento, J. A., Nitrini, R., Takahashi, D., & Caramelli, P. (2004). Hyperphosphorylated tau protein in the cerebrospinal fluid of patients with Alzheimer's disease and other dementias: preliminary findings. Arquivos De Neuro-psiquiatria, 62(3B), pp. 751-5.
Hartmann AP, et al. Hyperphosphorylated Tau Protein in the Cerebrospinal Fluid of Patients With Alzheimer's Disease and Other Dementias: Preliminary Findings. Arq Neuropsiquiatr. 2004;62(3B):751-5. PubMed PMID: 15476062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperphosphorylated tau protein in the cerebrospinal fluid of patients with Alzheimer's disease and other dementias: preliminary findings. AU - Hartmann,Ana Paula Barbosa Jeronimo, AU - Almeida,Sérgio Monteiro de, AU - Livramento,José Antonio, AU - Nitrini,Ricardo, AU - Takahashi,Daniel, AU - Caramelli,Paulo, Y1 - 2004/10/05/ PY - 2004/10/12/pubmed PY - 2005/7/15/medline PY - 2004/10/12/entrez SP - 751 EP - 5 JF - Arquivos de neuro-psiquiatria JO - Arq Neuropsiquiatr VL - 62 IS - 3B N2 - Alzheimer's disease (AD) is pathologically characterized by the accumulation of amyloid plaques and tau-associated neurofibrillary tangles in the cerebral tissue. The search for antemortem biomarkers is intense including analysis of cerebrospinal fluid (CSF) beta-amyloid and tau proteins concentrations seeking for an accurate and early diagnosis. Levels of hyperphosphorylated tau at threonine 181 were measured in the CSF of 34 patients with AD (19 with senile AD - SAD and eight with presenile AD - PSAD) and seven with other dementias (OD). The levels of CSF phosphotau were significantly higher in the AD patients compared to OD (AUC 0.812), with no association with severity of dementia, age of onset, duration of the disease or scores in the Mini-Mental State Examination. There were no differences of phosphotau levels between SAD and PSAD patients. These findings corroborate some previous studies and indicate that CSF phosphotau may help to differentiate AD from other dementias. SN - 0004-282X UR - https://www.unboundmedicine.com/medline/citation/15476062/Hyperphosphorylated_tau_protein_in_the_cerebrospinal_fluid_of_patients_with_Alzheimer's_disease_and_other_dementias:_preliminary_findings_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000500001&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -