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Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis.
Haematologica. 2004 Oct; 89(10):1194-8.H

Abstract

BACKGROUND AND OBJECTIVES

The diagnosis of polycythemia vera (PV) is based on clinical and biological criteria defined by either the Polycythemia Vera Study Group (PVSG) or the World Health Organization (WHO). Both the PVSG and WHO PV criteria have proved helpful and are extensively used, yet diagnostic strategies and scheduling of biological investigations vary. We assessed the value of measuring serum erythropoietin (Epo) as a first intention diagnostic test in patients with absolute erythrocytosis (AE).

DESIGN AND METHODS

Serum and bone marrow (BM) samples of 241 patients with a suspicion of erythrocytosis were collected in 8 hospital centers. One hundred and ninety had an absolute erythrocytosis (116 had PV, 66 had secondary erythrocytosis and 4 had idiopathic erythrocytosis). Serum Epo was assayed (ELISA) in 186. Statistical analysis (ROC curves) was used to define serum Epo thresholds that were specific for PV and secondary erythrocytosis and to analyze the diagnostic value of a low or high serum Epo level.

RESULTS

A large majority of PV patients (87% or 101/116) had a serum Epo level below the normal range in healthy patients (3.3 IU/L), giving this value a specificity of 97% with a 97.8% positive predictive value for the diagnosis of PV. Statistical analysis (ROC curves) defined two thresholds allowing a specific and direct diagnosis of 65.6% (65/99) of untreated PV (Epo < 1.4 IU/L) and 19.7% (13/66) of those with secondary erythrocytosis (Epo > 13.7 IU/L).

INTERPRETATION AND CONCLUSIONS

Based on these data, we propose that measurement of serum Epo level, a simple, reliable and inexpensive test, should be considered as a first intention diagnostic test for patients with absolute erythrocytosis.

Authors+Show Affiliations

Laboratories of Hematology of Centre Hospitalier Universitaire, Grenoble, France. pmossuz@chu-grenoble.fr <pmossuz@chu-grenoble.fr>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15477203

Citation

Mossuz, Pascal, et al. "Diagnostic Value of Serum Erythropoietin Level in Patients With Absolute Erythrocytosis." Haematologica, vol. 89, no. 10, 2004, pp. 1194-8.
Mossuz P, Girodon F, Donnard M, et al. Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis. Haematologica. 2004;89(10):1194-8.
Mossuz, P., Girodon, F., Donnard, M., Latger-Cannard, V., Dobo, I., Boiret, N., Lecron, J. C., Binquet, C., Barro, C., Hermouet, S., & Praloran, V. (2004). Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis. Haematologica, 89(10), 1194-8.
Mossuz P, et al. Diagnostic Value of Serum Erythropoietin Level in Patients With Absolute Erythrocytosis. Haematologica. 2004;89(10):1194-8. PubMed PMID: 15477203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis. AU - Mossuz,Pascal, AU - Girodon,François, AU - Donnard,Magali, AU - Latger-Cannard,Véronique, AU - Dobo,Irène, AU - Boiret,Nathalie, AU - Lecron,Jean Claude, AU - Binquet,Christine, AU - Barro,Claire, AU - Hermouet,Sylvie, AU - Praloran,Vincent, PY - 2004/10/13/pubmed PY - 2006/6/17/medline PY - 2004/10/13/entrez SP - 1194 EP - 8 JF - Haematologica JO - Haematologica VL - 89 IS - 10 N2 - BACKGROUND AND OBJECTIVES: The diagnosis of polycythemia vera (PV) is based on clinical and biological criteria defined by either the Polycythemia Vera Study Group (PVSG) or the World Health Organization (WHO). Both the PVSG and WHO PV criteria have proved helpful and are extensively used, yet diagnostic strategies and scheduling of biological investigations vary. We assessed the value of measuring serum erythropoietin (Epo) as a first intention diagnostic test in patients with absolute erythrocytosis (AE). DESIGN AND METHODS: Serum and bone marrow (BM) samples of 241 patients with a suspicion of erythrocytosis were collected in 8 hospital centers. One hundred and ninety had an absolute erythrocytosis (116 had PV, 66 had secondary erythrocytosis and 4 had idiopathic erythrocytosis). Serum Epo was assayed (ELISA) in 186. Statistical analysis (ROC curves) was used to define serum Epo thresholds that were specific for PV and secondary erythrocytosis and to analyze the diagnostic value of a low or high serum Epo level. RESULTS: A large majority of PV patients (87% or 101/116) had a serum Epo level below the normal range in healthy patients (3.3 IU/L), giving this value a specificity of 97% with a 97.8% positive predictive value for the diagnosis of PV. Statistical analysis (ROC curves) defined two thresholds allowing a specific and direct diagnosis of 65.6% (65/99) of untreated PV (Epo < 1.4 IU/L) and 19.7% (13/66) of those with secondary erythrocytosis (Epo > 13.7 IU/L). INTERPRETATION AND CONCLUSIONS: Based on these data, we propose that measurement of serum Epo level, a simple, reliable and inexpensive test, should be considered as a first intention diagnostic test for patients with absolute erythrocytosis. SN - 1592-8721 UR - https://www.unboundmedicine.com/medline/citation/15477203/Diagnostic_value_of_serum_erythropoietin_level_in_patients_with_absolute_erythrocytosis_ L2 - https://antibodies.cancer.gov/detail/CPTC-TIMP1-2 DB - PRIME DP - Unbound Medicine ER -