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Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction.
Circulation 2004; 110(16):2349-54Circ

Abstract

BACKGROUND

Inflammation has a pathogenetic role in acute myocardial infarction (MI). Pentraxin-3 (PTX3), a long pentraxin produced in response to inflammatory stimuli and highly expressed in the heart, was shown to peak in plasma approximately 7 hours after MI. The aim of this study was to assess the prognostic value of PTX3 in MI compared with the best-known and clinically relevant biological markers.

METHODS AND RESULTS

In 724 patients with MI and ST elevation, PTX3, C-reactive protein (CRP), creatine kinase (CK), troponin T (TnT), and N-terminal pro-brain natriuretic peptide (NT-proBNP) were assayed at entry, a median of 3 hours, and the following morning, a median of 22 hours from symptom onset. With respect to outcome events occurring over 3 months after the index event, median PTX3 values were 7.08 ng/mL in event-free patients, 16.12 ng/mL in patients who died, 9.12 ng/mL in patients with nonfatal heart failure, and 6.88 ng/mL in patients with nonfatal residual ischemia (overall P<0.0001). Multivariate analysis including CRP, CK, TnT, and NT-proBNP showed that only age > or =70 years (OR, 2.11; 95% CI, 1.04 to 4.31), Killip class >1 at entry (OR, 2.20; 95% CI, 1.14 to 4.25), and PTX3 (>10.73 ng/mL) (OR, 3.55; 95% CI, 1.43 to 8.83) independently predicted 3-month mortality. Biomarkers predicting the combined end point of death and heart failure in survivors were the highest tertile of PTX3 and of NT-proBNP and a CK ratio >6.

CONCLUSIONS

In a representative contemporary sample of patients with MI with ST elevation, the acute-phase protein PTX3 but not the liver-derived short pentraxin CRP or other cardiac biomarkers (NT-proBNP, TnT, CK) predicted 3-month mortality after adjustment for major risk factors and other acute-phase prognostic markers.

Authors+Show Affiliations

Mario Negri Institute for Pharmacological Research, Milan, Italy. latini@marionegri.it.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Studies
Journal Article
Research Support, Non-U.S. Gov't
Validation Studies

Language

eng

PubMed ID

15477419

Citation

Latini, Roberto, et al. "Prognostic Significance of the Long Pentraxin PTX3 in Acute Myocardial Infarction." Circulation, vol. 110, no. 16, 2004, pp. 2349-54.
Latini R, Maggioni AP, Peri G, et al. Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. Circulation. 2004;110(16):2349-54.
Latini, R., Maggioni, A. P., Peri, G., Gonzini, L., Lucci, D., Mocarelli, P., ... Mantovani, A. (2004). Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. Circulation, 110(16), pp. 2349-54.
Latini R, et al. Prognostic Significance of the Long Pentraxin PTX3 in Acute Myocardial Infarction. Circulation. 2004 Oct 19;110(16):2349-54. PubMed PMID: 15477419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. AU - Latini,Roberto, AU - Maggioni,Aldo P, AU - Peri,Giuseppe, AU - Gonzini,Lucio, AU - Lucci,Donata, AU - Mocarelli,Paolo, AU - Vago,Luca, AU - Pasqualini,Fabio, AU - Signorini,Stefano, AU - Soldateschi,Dario, AU - Tarli,Lorenzo, AU - Schweiger,Carlo, AU - Fresco,Claudio, AU - Cecere,Rossana, AU - Tognoni,Gianni, AU - Mantovani,Alberto, AU - ,, Y1 - 2004/10/11/ PY - 2004/10/13/pubmed PY - 2005/7/7/medline PY - 2004/10/13/entrez SP - 2349 EP - 54 JF - Circulation JO - Circulation VL - 110 IS - 16 N2 - BACKGROUND: Inflammation has a pathogenetic role in acute myocardial infarction (MI). Pentraxin-3 (PTX3), a long pentraxin produced in response to inflammatory stimuli and highly expressed in the heart, was shown to peak in plasma approximately 7 hours after MI. The aim of this study was to assess the prognostic value of PTX3 in MI compared with the best-known and clinically relevant biological markers. METHODS AND RESULTS: In 724 patients with MI and ST elevation, PTX3, C-reactive protein (CRP), creatine kinase (CK), troponin T (TnT), and N-terminal pro-brain natriuretic peptide (NT-proBNP) were assayed at entry, a median of 3 hours, and the following morning, a median of 22 hours from symptom onset. With respect to outcome events occurring over 3 months after the index event, median PTX3 values were 7.08 ng/mL in event-free patients, 16.12 ng/mL in patients who died, 9.12 ng/mL in patients with nonfatal heart failure, and 6.88 ng/mL in patients with nonfatal residual ischemia (overall P<0.0001). Multivariate analysis including CRP, CK, TnT, and NT-proBNP showed that only age > or =70 years (OR, 2.11; 95% CI, 1.04 to 4.31), Killip class >1 at entry (OR, 2.20; 95% CI, 1.14 to 4.25), and PTX3 (>10.73 ng/mL) (OR, 3.55; 95% CI, 1.43 to 8.83) independently predicted 3-month mortality. Biomarkers predicting the combined end point of death and heart failure in survivors were the highest tertile of PTX3 and of NT-proBNP and a CK ratio >6. CONCLUSIONS: In a representative contemporary sample of patients with MI with ST elevation, the acute-phase protein PTX3 but not the liver-derived short pentraxin CRP or other cardiac biomarkers (NT-proBNP, TnT, CK) predicted 3-month mortality after adjustment for major risk factors and other acute-phase prognostic markers. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/15477419/Prognostic_significance_of_the_long_pentraxin_PTX3_in_acute_myocardial_infarction_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.CIR.0000145167.30987.2E?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -