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Molecular basis and diagnostics of hereditary colorectal cancers.
Ann Med 2004; 36(5):379-88AM

Abstract

Hereditary colorectal cancer syndromes are classified according to the presence of unusually large number of adenomatous or hamartomatous polyps, or their absence. The latter category includes hereditary non-polyposis colorectal cancer (Lynch syndrome) and its variants Muir-Torre and Turcot's syndromes. Adenomatous polyposis syndromes include familial adenomatous polyposis (FAP) and its variants, and the recently identified MYH- (mutY homolog)-associated polyposis. Hamartomatous polyposis syndromes include juvenile polyposis, Peutz-Jeghers syndrome, and Cowden syndrome, which is now included within the broader category 'PTEN (phosphatase and tensin homolog) hamartoma tumour syndrome'. Other syndromes such as the 'hereditary breast and colon cancer' and 'familial colorectal cancer' are not yet fully characterized. This review addresses the molecular basis of these syndromes with particular reference to the recent advances in this rapidly progressive field and the applications of such knowledge in diagnosis and management.

Authors+Show Affiliations

Department of Medical Genetics, University of Helsinki, Helsinki, Finland. Wael.Abdel-Rahman@helsinkiNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15478312

Citation

Abdel-Rahman, Wael M., and Päivi Peltomäki. "Molecular Basis and Diagnostics of Hereditary Colorectal Cancers." Annals of Medicine, vol. 36, no. 5, 2004, pp. 379-88.
Abdel-Rahman WM, Peltomäki P. Molecular basis and diagnostics of hereditary colorectal cancers. Ann Med. 2004;36(5):379-88.
Abdel-Rahman, W. M., & Peltomäki, P. (2004). Molecular basis and diagnostics of hereditary colorectal cancers. Annals of Medicine, 36(5), pp. 379-88.
Abdel-Rahman WM, Peltomäki P. Molecular Basis and Diagnostics of Hereditary Colorectal Cancers. Ann Med. 2004;36(5):379-88. PubMed PMID: 15478312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular basis and diagnostics of hereditary colorectal cancers. AU - Abdel-Rahman,Wael M, AU - Peltomäki,Päivi, PY - 2004/10/14/pubmed PY - 2005/3/22/medline PY - 2004/10/14/entrez SP - 379 EP - 88 JF - Annals of medicine JO - Ann. Med. VL - 36 IS - 5 N2 - Hereditary colorectal cancer syndromes are classified according to the presence of unusually large number of adenomatous or hamartomatous polyps, or their absence. The latter category includes hereditary non-polyposis colorectal cancer (Lynch syndrome) and its variants Muir-Torre and Turcot's syndromes. Adenomatous polyposis syndromes include familial adenomatous polyposis (FAP) and its variants, and the recently identified MYH- (mutY homolog)-associated polyposis. Hamartomatous polyposis syndromes include juvenile polyposis, Peutz-Jeghers syndrome, and Cowden syndrome, which is now included within the broader category 'PTEN (phosphatase and tensin homolog) hamartoma tumour syndrome'. Other syndromes such as the 'hereditary breast and colon cancer' and 'familial colorectal cancer' are not yet fully characterized. This review addresses the molecular basis of these syndromes with particular reference to the recent advances in this rapidly progressive field and the applications of such knowledge in diagnosis and management. SN - 0785-3890 UR - https://www.unboundmedicine.com/medline/citation/15478312/Molecular_basis_and_diagnostics_of_hereditary_colorectal_cancers_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15478312.ui DB - PRIME DP - Unbound Medicine ER -