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Effectiveness of montelukast in the treatment of cough variant asthma.
Ann Allergy Asthma Immunol. 2004 Sep; 93(3):232-6.AA

Abstract

BACKGROUND

Antileukotriene agents have been shown to be beneficial in chronic asthma. Although patients with cough variant asthma have cough with minimal wheezing and dyspnea, airway hyperresponsiveness from chronic inflammation is believed to be the underlying mechanism.

OBJECTIVE

To evaluate the effectiveness of montelukast, a leukotriene receptor antagonist, in the treatment of cough variant asthma.

METHODS

Fourteen patients with cough variant asthma participated in a randomized, double-blind, placebo-controlled trial with a 7- to 10-day baseline period and a 4-week treatment period with montelukast, 10 mg, or placebo daily. Inclusion criteria were (1) chronic cough with a duration of at least 4 weeks with minimal or no wheezing or dyspnea and (2) forced expiratory volume in 1 second of 50% to 85% of predicted and reversibility of 12% with use of an inhaled beta-agonist or forced expiratory volume in 1 second greater than 85% and positive methacholine challenge results. Patients fulfilled the minimum criteria for cough frequency and symptom scores for randomization.

RESULTS

Eight patients received montelukast and 6 received placebo. The primary efficacy variable, mean percentage change from baseline in cough frequency, was significantly improved by the second week, and by the fourth week the mean percentage change from baseline was 75.7% for the treatment group and 20.7% for the placebo group.

CONCLUSIONS

The leukotriene receptor antagonist montelukast seems to be effective in the treatment of cough variant asthma. Larger studies are recommended to confirm this effect.

Authors+Show Affiliations

Division of Clinical Allergy and Immunology, UCLA School of Medicine, Los Angeles, California, USA.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15478381

Citation

Spector, Sheldon L., and Ricardo A. Tan. "Effectiveness of Montelukast in the Treatment of Cough Variant Asthma." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 93, no. 3, 2004, pp. 232-6.
Spector SL, Tan RA. Effectiveness of montelukast in the treatment of cough variant asthma. Ann Allergy Asthma Immunol. 2004;93(3):232-6.
Spector, S. L., & Tan, R. A. (2004). Effectiveness of montelukast in the treatment of cough variant asthma. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 93(3), 232-6.
Spector SL, Tan RA. Effectiveness of Montelukast in the Treatment of Cough Variant Asthma. Ann Allergy Asthma Immunol. 2004;93(3):232-6. PubMed PMID: 15478381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of montelukast in the treatment of cough variant asthma. AU - Spector,Sheldon L, AU - Tan,Ricardo A, PY - 2004/10/14/pubmed PY - 2004/11/2/medline PY - 2004/10/14/entrez SP - 232 EP - 6 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann Allergy Asthma Immunol VL - 93 IS - 3 N2 - BACKGROUND: Antileukotriene agents have been shown to be beneficial in chronic asthma. Although patients with cough variant asthma have cough with minimal wheezing and dyspnea, airway hyperresponsiveness from chronic inflammation is believed to be the underlying mechanism. OBJECTIVE: To evaluate the effectiveness of montelukast, a leukotriene receptor antagonist, in the treatment of cough variant asthma. METHODS: Fourteen patients with cough variant asthma participated in a randomized, double-blind, placebo-controlled trial with a 7- to 10-day baseline period and a 4-week treatment period with montelukast, 10 mg, or placebo daily. Inclusion criteria were (1) chronic cough with a duration of at least 4 weeks with minimal or no wheezing or dyspnea and (2) forced expiratory volume in 1 second of 50% to 85% of predicted and reversibility of 12% with use of an inhaled beta-agonist or forced expiratory volume in 1 second greater than 85% and positive methacholine challenge results. Patients fulfilled the minimum criteria for cough frequency and symptom scores for randomization. RESULTS: Eight patients received montelukast and 6 received placebo. The primary efficacy variable, mean percentage change from baseline in cough frequency, was significantly improved by the second week, and by the fourth week the mean percentage change from baseline was 75.7% for the treatment group and 20.7% for the placebo group. CONCLUSIONS: The leukotriene receptor antagonist montelukast seems to be effective in the treatment of cough variant asthma. Larger studies are recommended to confirm this effect. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/15478381/Effectiveness_of_montelukast_in_the_treatment_of_cough_variant_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)61493-7 DB - PRIME DP - Unbound Medicine ER -