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Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population.
Clin Prostate Cancer. 2004 Sep; 3(2):98-103.CP

Abstract

Shorter androgen receptor gene CAG repeat length has been associated with an increased risk of prostate cancer, an earlier age of onset, and more advanced stage of disease. Studies comparing the distribution of CAG repeat lengths within different populations have reported that racial groups with higher prostate cancer incidence also have shorter CAG repeat lengths. We evaluated CAG repeat length in 685 black men in Louisiana, South Carolina, and the District of Columbia who were participating in prostate cancer screening, comparing the 118 who were diagnosed with prostate cancer with 567 who had normal serum prostate-specific antigen levels and no evidence of cancer on digital rectal examination. The median CAG repeat length was 21 among cases and 19 among controls (P = 0.11). Cases were significantly older than controls, with a median age of 68 years compared with 54 years (P < 0.0001). After adjusting for age, we found no association between prostate cancer risk and CAG repeat length (odds ratio, 1.05; 95% CI, 0.98-1.13; P = 0.16). Dividing CAG repeat lengths into septiles and calculating the odds ratio for each revealed no specific repeat-length range with a significantly elevated or depressed risk of prostate cancer, but a trend test showed a significant association between longer CAG repeat lengths and an elevated risk of prostate cancer (P = 0.02). Neither grade nor stage was associated with CAG repeat length. This study confirms earlier reports that black men have shorter CAG repeat lengths than reported white and Asian populations. We did not find an increased risk of prostate cancer among black men with fewer CAG repeats.

Authors+Show Affiliations

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. timothy_gilligan@dfci.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15479493

Citation

Gilligan, Timothy, et al. "Absence of a Correlation of Androgen Receptor Gene CAG Repeat Length and Prostate Cancer Risk in an African-American Population." Clinical Prostate Cancer, vol. 3, no. 2, 2004, pp. 98-103.
Gilligan T, Manola J, Sartor O, et al. Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. Clin Prostate Cancer. 2004;3(2):98-103.
Gilligan, T., Manola, J., Sartor, O., Weinrich, S. P., Moul, J. W., & Kantoff, P. W. (2004). Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. Clinical Prostate Cancer, 3(2), 98-103.
Gilligan T, et al. Absence of a Correlation of Androgen Receptor Gene CAG Repeat Length and Prostate Cancer Risk in an African-American Population. Clin Prostate Cancer. 2004;3(2):98-103. PubMed PMID: 15479493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. AU - Gilligan,Timothy, AU - Manola,Judith, AU - Sartor,Oliver, AU - Weinrich,Sally P, AU - Moul,Judd W, AU - Kantoff,Philip W, PY - 2004/10/14/pubmed PY - 2004/12/16/medline PY - 2004/10/14/entrez SP - 98 EP - 103 JF - Clinical prostate cancer JO - Clin Prostate Cancer VL - 3 IS - 2 N2 - Shorter androgen receptor gene CAG repeat length has been associated with an increased risk of prostate cancer, an earlier age of onset, and more advanced stage of disease. Studies comparing the distribution of CAG repeat lengths within different populations have reported that racial groups with higher prostate cancer incidence also have shorter CAG repeat lengths. We evaluated CAG repeat length in 685 black men in Louisiana, South Carolina, and the District of Columbia who were participating in prostate cancer screening, comparing the 118 who were diagnosed with prostate cancer with 567 who had normal serum prostate-specific antigen levels and no evidence of cancer on digital rectal examination. The median CAG repeat length was 21 among cases and 19 among controls (P = 0.11). Cases were significantly older than controls, with a median age of 68 years compared with 54 years (P < 0.0001). After adjusting for age, we found no association between prostate cancer risk and CAG repeat length (odds ratio, 1.05; 95% CI, 0.98-1.13; P = 0.16). Dividing CAG repeat lengths into septiles and calculating the odds ratio for each revealed no specific repeat-length range with a significantly elevated or depressed risk of prostate cancer, but a trend test showed a significant association between longer CAG repeat lengths and an elevated risk of prostate cancer (P = 0.02). Neither grade nor stage was associated with CAG repeat length. This study confirms earlier reports that black men have shorter CAG repeat lengths than reported white and Asian populations. We did not find an increased risk of prostate cancer among black men with fewer CAG repeats. SN - 1540-0352 UR - https://www.unboundmedicine.com/medline/citation/15479493/Absence_of_a_correlation_of_androgen_receptor_gene_CAG_repeat_length_and_prostate_cancer_risk_in_an_African_American_population_ L2 - http://www.diseaseinfosearch.org/result/9175 DB - PRIME DP - Unbound Medicine ER -