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Vitamin B6 level is associated with symptoms of depression.

Abstract

BACKGROUND

A low level of vitamin B6 might theoretically cause depression as vitamin B6 is a cofactor in the tryptophan-serotonin pathway. In the present study, we examined the association between depression and the phosphate derivative of vitamin B6 in plasma, pyridoxal phosphate (PLP).

METHODS

In 140 individuals, symptoms of depression were evaluated by the Major Depression Inventory, and biochemical markers of vitamin B deficiency were measured.

RESULTS

We found that 18 (13%) individuals were depressed. A low plasma level of PLP was significantly associated with the depression score (p=0.002). No significant association was found between depression and plasma vitamin B12 (p=0.13), plasma methylmalonic acid (p=0.67), erythrocyte folate (p=0.77), and plasma total homocysteine (p=0.16).

CONCLUSION

Our study suggests that a low level of plasma PLP is associated with symptoms of depression. Randomized trials are now justified and needed in order to examine whether treatment with vitamin B6 may improve symptoms of depression.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Biochemistry, Aarhus University Hospital, AKH, Aarhus, Denmark. am.hvas@dadlnet.dk

    , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Cross-Sectional Studies
    Depressive Disorder
    Female
    Humans
    Male
    Middle Aged
    Pyridoxal Phosphate
    Risk Factors
    Vitamin B 6 Deficiency

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15479988

    Citation

    Hvas, Anne-Mette, et al. "Vitamin B6 Level Is Associated With Symptoms of Depression." Psychotherapy and Psychosomatics, vol. 73, no. 6, 2004, pp. 340-3.
    Hvas AM, Juul S, Bech P, et al. Vitamin B6 level is associated with symptoms of depression. Psychother Psychosom. 2004;73(6):340-3.
    Hvas, A. M., Juul, S., Bech, P., & Nexø, E. (2004). Vitamin B6 level is associated with symptoms of depression. Psychotherapy and Psychosomatics, 73(6), pp. 340-3.
    Hvas AM, et al. Vitamin B6 Level Is Associated With Symptoms of Depression. Psychother Psychosom. 2004;73(6):340-3. PubMed PMID: 15479988.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin B6 level is associated with symptoms of depression. AU - Hvas,Anne-Mette, AU - Juul,Svend, AU - Bech,Per, AU - Nexø,Ebba, PY - 2004/10/14/pubmed PY - 2005/1/15/medline PY - 2004/10/14/entrez SP - 340 EP - 3 JF - Psychotherapy and psychosomatics JO - Psychother Psychosom VL - 73 IS - 6 N2 - BACKGROUND: A low level of vitamin B6 might theoretically cause depression as vitamin B6 is a cofactor in the tryptophan-serotonin pathway. In the present study, we examined the association between depression and the phosphate derivative of vitamin B6 in plasma, pyridoxal phosphate (PLP). METHODS: In 140 individuals, symptoms of depression were evaluated by the Major Depression Inventory, and biochemical markers of vitamin B deficiency were measured. RESULTS: We found that 18 (13%) individuals were depressed. A low plasma level of PLP was significantly associated with the depression score (p=0.002). No significant association was found between depression and plasma vitamin B12 (p=0.13), plasma methylmalonic acid (p=0.67), erythrocyte folate (p=0.77), and plasma total homocysteine (p=0.16). CONCLUSION: Our study suggests that a low level of plasma PLP is associated with symptoms of depression. Randomized trials are now justified and needed in order to examine whether treatment with vitamin B6 may improve symptoms of depression. SN - 0033-3190 UR - https://www.unboundmedicine.com/medline/citation/15479988/full_citation L2 - https://www.karger.com?DOI=10.1159/000080386 DB - PRIME DP - Unbound Medicine ER -