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Breast-feeding reduces the risk of asthma during the first 4 years of life.
J Allergy Clin Immunol. 2004 Oct; 114(4):755-60.JA

Abstract

BACKGROUND

The evidence for a preventive effect of breast-feeding on asthma and other allergic diseases in childhood is inconclusive.

OBJECTIVE

The aim of this study was to investigate the effect of breast-feeding on asthma and sensitization to airborne allergens among children up to 4 years of age.

METHODS

A birth cohort of 4089 children was followed. Exposure data were collected at 2 months and 1 year of age. The total dose of breast milk was estimated by combining periods of exclusive and partial breast-feeding. Outcomes data were collected at 1, 2, and 4 years of age. The response rate at 4 years was 90%, and 73% participated in a clinical investigation, including blood sampling for analysis of specific IgE and lung function testing. Children with onset of wheeze during lactation (n=217) were excluded in some of the analyses to avoid disease-related modification of exposure.

RESULTS

Exclusive breast-feeding for 4 months or more reduced the risk of asthma at the age of 4 years (odds ratio [OR], 0.72; 95% CI, 0.53-0.97), irrespective of sensitization to common airborne allergens (P=.72). Excluding children with wheeze during lactation tended to strengthen the risk estimate (OR, 0.64; 95% CI, 0.46-0.88). A duration of 3 months or more of partial breast-feeding seemed to offer additional protection; exclusive breast-feeding for 3 to 4 months combined with partial breast-feeding for 3 months or more resulted in an OR of 0.44 (95% CI, 0.21-0.87). The effects tended to be stronger in children without heredity for allergy (P interaction=.36).

CONCLUSION

Breast-feeding reduces the risk of asthma during the first 4 years of life.

Authors+Show Affiliations

Department of Occupational and Environmental Health, Stockholm County Council, Sweden. inger.kull@sma.sll.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15480312

Citation

Kull, Inger, et al. "Breast-feeding Reduces the Risk of Asthma During the First 4 Years of Life." The Journal of Allergy and Clinical Immunology, vol. 114, no. 4, 2004, pp. 755-60.
Kull I, Almqvist C, Lilja G, et al. Breast-feeding reduces the risk of asthma during the first 4 years of life. J Allergy Clin Immunol. 2004;114(4):755-60.
Kull, I., Almqvist, C., Lilja, G., Pershagen, G., & Wickman, M. (2004). Breast-feeding reduces the risk of asthma during the first 4 years of life. The Journal of Allergy and Clinical Immunology, 114(4), 755-60.
Kull I, et al. Breast-feeding Reduces the Risk of Asthma During the First 4 Years of Life. J Allergy Clin Immunol. 2004;114(4):755-60. PubMed PMID: 15480312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast-feeding reduces the risk of asthma during the first 4 years of life. AU - Kull,Inger, AU - Almqvist,Catarina, AU - Lilja,Gunnar, AU - Pershagen,Göran, AU - Wickman,Magnus, PY - 2004/10/14/pubmed PY - 2004/12/31/medline PY - 2004/10/14/entrez SP - 755 EP - 60 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 114 IS - 4 N2 - BACKGROUND: The evidence for a preventive effect of breast-feeding on asthma and other allergic diseases in childhood is inconclusive. OBJECTIVE: The aim of this study was to investigate the effect of breast-feeding on asthma and sensitization to airborne allergens among children up to 4 years of age. METHODS: A birth cohort of 4089 children was followed. Exposure data were collected at 2 months and 1 year of age. The total dose of breast milk was estimated by combining periods of exclusive and partial breast-feeding. Outcomes data were collected at 1, 2, and 4 years of age. The response rate at 4 years was 90%, and 73% participated in a clinical investigation, including blood sampling for analysis of specific IgE and lung function testing. Children with onset of wheeze during lactation (n=217) were excluded in some of the analyses to avoid disease-related modification of exposure. RESULTS: Exclusive breast-feeding for 4 months or more reduced the risk of asthma at the age of 4 years (odds ratio [OR], 0.72; 95% CI, 0.53-0.97), irrespective of sensitization to common airborne allergens (P=.72). Excluding children with wheeze during lactation tended to strengthen the risk estimate (OR, 0.64; 95% CI, 0.46-0.88). A duration of 3 months or more of partial breast-feeding seemed to offer additional protection; exclusive breast-feeding for 3 to 4 months combined with partial breast-feeding for 3 months or more resulted in an OR of 0.44 (95% CI, 0.21-0.87). The effects tended to be stronger in children without heredity for allergy (P interaction=.36). CONCLUSION: Breast-feeding reduces the risk of asthma during the first 4 years of life. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/15480312/Breast_feeding_reduces_the_risk_of_asthma_during_the_first_4_years_of_life_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674904020810 DB - PRIME DP - Unbound Medicine ER -