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Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study.
J Allergy Clin Immunol. 2004 Oct; 114(4):807-13.JA

Abstract

BACKGROUND

Two factors thought to influence the risk of asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids. Although house dust mite allergen avoidance has been used as a preventive strategy in several trials, the effect of omega-3 fatty acid supplementation in the primary prevention of asthma and allergic disease is not known.

OBJECTIVE

To measure the effects of dietary supplementation with omega-3 fatty acids and house dust mite allergen avoidance in children with a family history of asthma.

METHODS

A total of 616 children at high risk of asthma were enrolled antenatally in a randomized controlled trial, and 526 children remained in the trial at age 3 years. The outcomes were symptoms of allergic disease and allergen sensitization.

RESULTS

There was a significant 10.0% (95% CI, 3.7-16.4) reduction in the prevalence of cough in atopic children in the active diet group (P=.003; number needed to treat, 10) but a negligible 1.1% (95% CI, -7.1 to 9.5) reduction cough among nonatopic children. There was a 7.2% (95% CI, 10.11-14.3) reduction in sensitization to house dust mite in the active allergen avoidance group (P=.05; number needed to treat, 14). No significant differences in wheeze were found with either intervention.

CONCLUSION

These results suggest that our interventions, designed to be used in simple public health campaigns, may have a role in preventing the development of allergic sensitization and airways disease in early childhood. This offers the prospect of reducing allergic disease in later life.

Authors+Show Affiliations

Discipline of Paediatrics and Child Health, Children's Hospital at Westmead Clinical School, University of Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15480319

Citation

Peat, Jennifer K., et al. "Three-year Outcomes of Dietary Fatty Acid Modification and House Dust Mite Reduction in the Childhood Asthma Prevention Study." The Journal of Allergy and Clinical Immunology, vol. 114, no. 4, 2004, pp. 807-13.
Peat JK, Mihrshahi S, Kemp AS, et al. Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study. J Allergy Clin Immunol. 2004;114(4):807-13.
Peat, J. K., Mihrshahi, S., Kemp, A. S., Marks, G. B., Tovey, E. R., Webb, K., Mellis, C. M., & Leeder, S. R. (2004). Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study. The Journal of Allergy and Clinical Immunology, 114(4), 807-13.
Peat JK, et al. Three-year Outcomes of Dietary Fatty Acid Modification and House Dust Mite Reduction in the Childhood Asthma Prevention Study. J Allergy Clin Immunol. 2004;114(4):807-13. PubMed PMID: 15480319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study. AU - Peat,Jennifer K, AU - Mihrshahi,Seema, AU - Kemp,Andrew S, AU - Marks,Guy B, AU - Tovey,Euan R, AU - Webb,Karen, AU - Mellis,Craig M, AU - Leeder,Stephen R, PY - 2004/10/14/pubmed PY - 2004/12/31/medline PY - 2004/10/14/entrez SP - 807 EP - 13 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 114 IS - 4 N2 - BACKGROUND: Two factors thought to influence the risk of asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids. Although house dust mite allergen avoidance has been used as a preventive strategy in several trials, the effect of omega-3 fatty acid supplementation in the primary prevention of asthma and allergic disease is not known. OBJECTIVE: To measure the effects of dietary supplementation with omega-3 fatty acids and house dust mite allergen avoidance in children with a family history of asthma. METHODS: A total of 616 children at high risk of asthma were enrolled antenatally in a randomized controlled trial, and 526 children remained in the trial at age 3 years. The outcomes were symptoms of allergic disease and allergen sensitization. RESULTS: There was a significant 10.0% (95% CI, 3.7-16.4) reduction in the prevalence of cough in atopic children in the active diet group (P=.003; number needed to treat, 10) but a negligible 1.1% (95% CI, -7.1 to 9.5) reduction cough among nonatopic children. There was a 7.2% (95% CI, 10.11-14.3) reduction in sensitization to house dust mite in the active allergen avoidance group (P=.05; number needed to treat, 14). No significant differences in wheeze were found with either intervention. CONCLUSION: These results suggest that our interventions, designed to be used in simple public health campaigns, may have a role in preventing the development of allergic sensitization and airways disease in early childhood. This offers the prospect of reducing allergic disease in later life. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/15480319/Three_year_outcomes_of_dietary_fatty_acid_modification_and_house_dust_mite_reduction_in_the_Childhood_Asthma_Prevention_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674904020135 DB - PRIME DP - Unbound Medicine ER -