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Clinical effectiveness of a mite allergen-impermeable bed-covering system in asthmatic mite-sensitive patients.
J Allergy Clin Immunol 2004; 114(4):858-62JA

Abstract

BACKGROUND

Exposure to allergens plays a role in the development of bronchial hyperresponsiveness and in the chronic inflammatory response seen in asthmatic patients. House dust mites (HDMs) are an important source of allergen. Reduction of these allergens might lead to better lung function and reduction of asthma symptoms.

OBJECTIVE

The effect of HDM-impermeable covers on HDM allergen levels, peak flow values, and asthma symptoms were measured. Therefore a randomized clinical trial was carried out.

METHODS

Fifty-two allergic asthmatic patients were randomly allocated to use the HDM-impermeable or placebo covers. During the study period, daily peak flow and asthma symptom scores were recorded. Dust samples were taken from the mattresses.

RESULTS

We observed a significant reduction in HDM allergen levels on the mattresses after encasing them with HDM-impermeable covers (reduction of 87% of Der p 1 in micrograms per gram of dust; P <.001). Baseline symptoms were so low that no improvement could be established. Morning peak expiratory flow is significantly higher in the intervention group compared with that seen in the placebo group during the study period (beta=20.2; P <.01).

CONCLUSIONS

HDM-impermeable covers significantly decreased the level of HDM allergens. Furthermore, morning peak flow was significantly increased during the intervention period. This study indicates that HDM allergen-avoidance measures might have beneficial effects on allergen reduction and asthma outcome.

Authors+Show Affiliations

Department of General Practice, Research Institute Caphri, Maastricht University, The Netherlands. L.vandenbemt@hag.umcn.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15480327

Citation

van den Bemt, Lisette, et al. "Clinical Effectiveness of a Mite Allergen-impermeable Bed-covering System in Asthmatic Mite-sensitive Patients." The Journal of Allergy and Clinical Immunology, vol. 114, no. 4, 2004, pp. 858-62.
van den Bemt L, van Knapen L, de Vries MP, et al. Clinical effectiveness of a mite allergen-impermeable bed-covering system in asthmatic mite-sensitive patients. J Allergy Clin Immunol. 2004;114(4):858-62.
van den Bemt, L., van Knapen, L., de Vries, M. P., Jansen, M., Cloosterman, S., & van Schayck, C. P. (2004). Clinical effectiveness of a mite allergen-impermeable bed-covering system in asthmatic mite-sensitive patients. The Journal of Allergy and Clinical Immunology, 114(4), pp. 858-62.
van den Bemt L, et al. Clinical Effectiveness of a Mite Allergen-impermeable Bed-covering System in Asthmatic Mite-sensitive Patients. J Allergy Clin Immunol. 2004;114(4):858-62. PubMed PMID: 15480327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical effectiveness of a mite allergen-impermeable bed-covering system in asthmatic mite-sensitive patients. AU - van den Bemt,Lisette, AU - van Knapen,Lieke, AU - de Vries,Marjolein P, AU - Jansen,Margreet, AU - Cloosterman,Sonja, AU - van Schayck,Constant P, PY - 2004/10/14/pubmed PY - 2004/12/31/medline PY - 2004/10/14/entrez SP - 858 EP - 62 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 114 IS - 4 N2 - BACKGROUND: Exposure to allergens plays a role in the development of bronchial hyperresponsiveness and in the chronic inflammatory response seen in asthmatic patients. House dust mites (HDMs) are an important source of allergen. Reduction of these allergens might lead to better lung function and reduction of asthma symptoms. OBJECTIVE: The effect of HDM-impermeable covers on HDM allergen levels, peak flow values, and asthma symptoms were measured. Therefore a randomized clinical trial was carried out. METHODS: Fifty-two allergic asthmatic patients were randomly allocated to use the HDM-impermeable or placebo covers. During the study period, daily peak flow and asthma symptom scores were recorded. Dust samples were taken from the mattresses. RESULTS: We observed a significant reduction in HDM allergen levels on the mattresses after encasing them with HDM-impermeable covers (reduction of 87% of Der p 1 in micrograms per gram of dust; P <.001). Baseline symptoms were so low that no improvement could be established. Morning peak expiratory flow is significantly higher in the intervention group compared with that seen in the placebo group during the study period (beta=20.2; P <.01). CONCLUSIONS: HDM-impermeable covers significantly decreased the level of HDM allergens. Furthermore, morning peak flow was significantly increased during the intervention period. This study indicates that HDM allergen-avoidance measures might have beneficial effects on allergen reduction and asthma outcome. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/15480327/Clinical_effectiveness_of_a_mite_allergen_impermeable_bed_covering_system_in_asthmatic_mite_sensitive_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674904016719 DB - PRIME DP - Unbound Medicine ER -