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High prevalence of coeliac disease in siblings of children with type 1 diabetes.
Eur J Pediatr. 2005 Jan; 164(1):9-12.EJ

Abstract

Coeliac disease has been shown to occur more frequently among first-degree relatives of diabetic patients than in the general population. Our objective was to assess the prevalence of endomysium antibodies (EMA) in non-diabetic siblings of Czech diabetic children and to evaluate the effects of HLA-DQ polymorphisms in determining the genetic susceptibility to coeliac disease (CD) in these subjects. We investigated 240 siblings of diabetic children from 213 families (125 males and 115 females, aged 12.6+/-4.9 years, mean +/- SD). All subjects were tested for the total IgA level to exclude IgA deficiency, and for endomysium IgA to disclose CD. In five IgA-deficient subjects, anti-gliadin IgG was used instead. Small bowel biopsy was offered to subjects with confirmed positive EMA. The HLA-DQA1, -DQB1 genotypes were determined using PCR-SSP. Positive EMA were found in 9/240 (3.8%) subjects (three males, six females). The biopsy confirmed CD in six children, two had a normal mucosal finding and one refused the biopsy. The HLA-DQ2 polymorphism was more frequent among siblings with EMA (seven of nine) than in siblings without EMA (33%), corrected P = 0.031.

CONCLUSION

The 3.8% frequency of coeliac disease found in siblings of diabetic children is close to the 4.3% found previously in Czech children with type 1 diabetes mellitus and is substantially higher than the rate in the healthy children population.

Authors+Show Affiliations

Department of Paediatrics, 2nd Faculty of Medicine, V Uvalu 84, 150 06 Prague 5, Czech Republic. Zdenek.Sumnik@Lfmotol.cuni.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15480779

Citation

Sumnik, Zdenek, et al. "High Prevalence of Coeliac Disease in Siblings of Children With Type 1 Diabetes." European Journal of Pediatrics, vol. 164, no. 1, 2005, pp. 9-12.
Sumnik Z, Kolouskova S, Malcova H, et al. High prevalence of coeliac disease in siblings of children with type 1 diabetes. Eur J Pediatr. 2005;164(1):9-12.
Sumnik, Z., Kolouskova, S., Malcova, H., Vavrinec, J., Venhacova, J., Lebl, J., & Cinek, O. (2005). High prevalence of coeliac disease in siblings of children with type 1 diabetes. European Journal of Pediatrics, 164(1), 9-12.
Sumnik Z, et al. High Prevalence of Coeliac Disease in Siblings of Children With Type 1 Diabetes. Eur J Pediatr. 2005;164(1):9-12. PubMed PMID: 15480779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of coeliac disease in siblings of children with type 1 diabetes. AU - Sumnik,Zdenek, AU - Kolouskova,Stanislava, AU - Malcova,Hana, AU - Vavrinec,Jan, AU - Venhacova,Jitrenka, AU - Lebl,Jan, AU - Cinek,Ondrej, Y1 - 2004/10/07/ PY - 2004/06/01/received PY - 2004/08/28/accepted PY - 2004/10/14/pubmed PY - 2005/4/13/medline PY - 2004/10/14/entrez SP - 9 EP - 12 JF - European journal of pediatrics JO - Eur. J. Pediatr. VL - 164 IS - 1 N2 - UNLABELLED: Coeliac disease has been shown to occur more frequently among first-degree relatives of diabetic patients than in the general population. Our objective was to assess the prevalence of endomysium antibodies (EMA) in non-diabetic siblings of Czech diabetic children and to evaluate the effects of HLA-DQ polymorphisms in determining the genetic susceptibility to coeliac disease (CD) in these subjects. We investigated 240 siblings of diabetic children from 213 families (125 males and 115 females, aged 12.6+/-4.9 years, mean +/- SD). All subjects were tested for the total IgA level to exclude IgA deficiency, and for endomysium IgA to disclose CD. In five IgA-deficient subjects, anti-gliadin IgG was used instead. Small bowel biopsy was offered to subjects with confirmed positive EMA. The HLA-DQA1, -DQB1 genotypes were determined using PCR-SSP. Positive EMA were found in 9/240 (3.8%) subjects (three males, six females). The biopsy confirmed CD in six children, two had a normal mucosal finding and one refused the biopsy. The HLA-DQ2 polymorphism was more frequent among siblings with EMA (seven of nine) than in siblings without EMA (33%), corrected P = 0.031. CONCLUSION: The 3.8% frequency of coeliac disease found in siblings of diabetic children is close to the 4.3% found previously in Czech children with type 1 diabetes mellitus and is substantially higher than the rate in the healthy children population. SN - 0340-6199 UR - https://www.unboundmedicine.com/medline/citation/15480779/High_prevalence_of_coeliac_disease_in_siblings_of_children_with_type_1_diabetes_ L2 - https://dx.doi.org/10.1007/s00431-004-1547-1 DB - PRIME DP - Unbound Medicine ER -