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Screening of tissue transglutaminase antibody in healthy blood donors for celiac disease screening in the Turkish population.

Abstract

Celiac disease (CD) is a disease having the characteristic pathology of the mucosa of the small intestine. The prevalence of CD in the Turkish population has not been investigated previously. The present study was designed to determine the prevalence of CD in healthy blood donors. Serum samples of 2000 healthy blood donors presenting to Hacettepe University Faculty of Medicine Hospital Blood Bank were tested for tissue transglutaminase (tTG) IgA and IgG antibodies with enzyme-linked immunosorbent assay (ELISA; Euroimmune, Germany). The histopathological findings for the cases with positive serology were evaluated. The distribution of sex was 95.7% male, and 4.3% female. The mean age was 33 +/- 9. Among 2000 donors, 23 (1.15%) were positive for tTG IgA antibody and 3 (0.15%) were positive for tTG IgG antibody. None of the samples was positive for both antibodies. Serum total IgA was measured in two cases with only tTG IgG positivity and was found to be low in one case. Twelve subjects positive for tTG agreed to endoscopy and biopsy. Histopathological examination revealed changes classified as Marsh III-II in one, Marsh II in two, Marsh I in seven, and Marsh 0 in two donors. This was the first study conducted to determine the prevalence of tTG positivity in the Turkish population. The tTG antibody positivity prevalence in healthy blood donors was as high as 1.3%. This study shows that the prevalence of CD in the Turkish population is relatively high in comparison to that in the Western world.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine, Hacettepe University Medical Faculty Hospital, Ankara, Turkey.

    , , , , , ,

    Source

    Digestive diseases and sciences 49:9 2004 Sep pg 1479-84

    MeSH

    Adolescent
    Adult
    Age Distribution
    Aged
    Autoantibodies
    Blood Donors
    Celiac Disease
    Enzyme-Linked Immunosorbent Assay
    Female
    Global Health
    Health Surveys
    Humans
    Male
    Mass Screening
    Middle Aged
    Prevalence
    Risk Factors
    Sex Distribution
    Transglutaminases
    Turkey

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    15481323

    Citation

    Tatar, Gonca, et al. "Screening of Tissue Transglutaminase Antibody in Healthy Blood Donors for Celiac Disease Screening in the Turkish Population." Digestive Diseases and Sciences, vol. 49, no. 9, 2004, pp. 1479-84.
    Tatar G, Elsurer R, Simsek H, et al. Screening of tissue transglutaminase antibody in healthy blood donors for celiac disease screening in the Turkish population. Dig Dis Sci. 2004;49(9):1479-84.
    Tatar, G., Elsurer, R., Simsek, H., Balaban, Y. H., Hascelik, G., Ozcebe, O. I., ... Sokmensuer, C. (2004). Screening of tissue transglutaminase antibody in healthy blood donors for celiac disease screening in the Turkish population. Digestive Diseases and Sciences, 49(9), pp. 1479-84.
    Tatar G, et al. Screening of Tissue Transglutaminase Antibody in Healthy Blood Donors for Celiac Disease Screening in the Turkish Population. Dig Dis Sci. 2004;49(9):1479-84. PubMed PMID: 15481323.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Screening of tissue transglutaminase antibody in healthy blood donors for celiac disease screening in the Turkish population. AU - Tatar,Gonca, AU - Elsurer,Rengin, AU - Simsek,Halis, AU - Balaban,Yasemin H, AU - Hascelik,Gulsen, AU - Ozcebe,Osman I, AU - Buyukasik,Yahya, AU - Sokmensuer,Cenk, PY - 2004/10/16/pubmed PY - 2005/3/11/medline PY - 2004/10/16/entrez SP - 1479 EP - 84 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 49 IS - 9 N2 - Celiac disease (CD) is a disease having the characteristic pathology of the mucosa of the small intestine. The prevalence of CD in the Turkish population has not been investigated previously. The present study was designed to determine the prevalence of CD in healthy blood donors. Serum samples of 2000 healthy blood donors presenting to Hacettepe University Faculty of Medicine Hospital Blood Bank were tested for tissue transglutaminase (tTG) IgA and IgG antibodies with enzyme-linked immunosorbent assay (ELISA; Euroimmune, Germany). The histopathological findings for the cases with positive serology were evaluated. The distribution of sex was 95.7% male, and 4.3% female. The mean age was 33 +/- 9. Among 2000 donors, 23 (1.15%) were positive for tTG IgA antibody and 3 (0.15%) were positive for tTG IgG antibody. None of the samples was positive for both antibodies. Serum total IgA was measured in two cases with only tTG IgG positivity and was found to be low in one case. Twelve subjects positive for tTG agreed to endoscopy and biopsy. Histopathological examination revealed changes classified as Marsh III-II in one, Marsh II in two, Marsh I in seven, and Marsh 0 in two donors. This was the first study conducted to determine the prevalence of tTG positivity in the Turkish population. The tTG antibody positivity prevalence in healthy blood donors was as high as 1.3%. This study shows that the prevalence of CD in the Turkish population is relatively high in comparison to that in the Western world. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/15481323/Screening_of_tissue_transglutaminase_antibody_in_healthy_blood_donors_for_celiac_disease_screening_in_the_Turkish_population_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15481323.ui DB - PRIME DP - Unbound Medicine ER -