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Antralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity.
J Gastroenterol Hepatol. 2004 Nov; 19(11):1257-63.JG

Abstract

BACKGROUND AND AIMS

Helicobacter pylori infection is linked with increased antralization at the gastric incisura. The present study aimed to determine if antralization is associated with altered gastric epithelial apoptosis and proliferation and with seropositivity of the cytotoxin-associated gene product A (CagA) of H. pylori.

METHODS

Gastric biopsies taken from the antrum, incisura, body and fundus of 75 patients (34 male, 41 female; mean age 59.5 years) were used for diagnosis of H. pylori infection and assessments of histological changes. Apoptosis and Ki-67 expression in epithelial cells were determined for the antral, incisura and body biopsies by immunohistochemistry. Serum samples were tested by enzyme-linked immunosorbent assays for anti-H. pylori and anti-CagA IgG antibodies.

RESULTS

Apoptotic index (AI) and Ki-67 proliferation index (PI) were greater in the presence (vs absence) of H. pylori infection at the antrum, incisura and body (all P < 0.001), and topographically associated with chronic gastritis and gastric atrophy/intestinal metaplasia at the antrum and incisura (all P < 0.001). Moreover, AI and PI were greater in the presence (vs absence) of antralization at the incisura (20.2 +/- 0.9 vs 11.4 +/- 0.1.1 and 48.9 +/- 2.5 vs 29.9 +/- 2.5, both P < 0.001). CagA seroprevalence was 41% in the 39 infected patients. CagA seropositivity was associated with gastric atrophy/intestinal metaplasia at the antrum (chi(2) = 4.67, P = 0.03) and incisura (chi(2) = 4.88, P = 0.03), but not associated with gastric epithelial apoptosis and Ki-67 expression, nor with antralization at the incisura.

CONCLUSIONS

Antralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity.

Authors+Show Affiliations

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15482532

Citation

Xia, Harry Hua-Xiang, et al. "Antralization of Gastric Incisura Is Topographically Associated With Increased Gastric Epithelial Apoptosis and Proliferation, but Not With CagA Seropositivity." Journal of Gastroenterology and Hepatology, vol. 19, no. 11, 2004, pp. 1257-63.
Xia HH, Wong BC, Zhang GS, et al. Antralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity. J Gastroenterol Hepatol. 2004;19(11):1257-63.
Xia, H. H., Wong, B. C., Zhang, G. S., Yang, Y., Wyatt, J. M., Adams, S., Cheung, K., Lam, S. K., & Talley, N. J. (2004). Antralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity. Journal of Gastroenterology and Hepatology, 19(11), 1257-63.
Xia HH, et al. Antralization of Gastric Incisura Is Topographically Associated With Increased Gastric Epithelial Apoptosis and Proliferation, but Not With CagA Seropositivity. J Gastroenterol Hepatol. 2004;19(11):1257-63. PubMed PMID: 15482532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity. AU - Xia,Harry Hua-Xiang, AU - Wong,Benjamin Chun-Yu, AU - Zhang,Gui-Shui, AU - Yang,Yi, AU - Wyatt,Jenny Ma, AU - Adams,Stuart, AU - Cheung,Karen, AU - Lam,Shiu Kum, AU - Talley,Nicholas J, PY - 2004/10/16/pubmed PY - 2005/3/23/medline PY - 2004/10/16/entrez SP - 1257 EP - 63 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 19 IS - 11 N2 - BACKGROUND AND AIMS: Helicobacter pylori infection is linked with increased antralization at the gastric incisura. The present study aimed to determine if antralization is associated with altered gastric epithelial apoptosis and proliferation and with seropositivity of the cytotoxin-associated gene product A (CagA) of H. pylori. METHODS: Gastric biopsies taken from the antrum, incisura, body and fundus of 75 patients (34 male, 41 female; mean age 59.5 years) were used for diagnosis of H. pylori infection and assessments of histological changes. Apoptosis and Ki-67 expression in epithelial cells were determined for the antral, incisura and body biopsies by immunohistochemistry. Serum samples were tested by enzyme-linked immunosorbent assays for anti-H. pylori and anti-CagA IgG antibodies. RESULTS: Apoptotic index (AI) and Ki-67 proliferation index (PI) were greater in the presence (vs absence) of H. pylori infection at the antrum, incisura and body (all P < 0.001), and topographically associated with chronic gastritis and gastric atrophy/intestinal metaplasia at the antrum and incisura (all P < 0.001). Moreover, AI and PI were greater in the presence (vs absence) of antralization at the incisura (20.2 +/- 0.9 vs 11.4 +/- 0.1.1 and 48.9 +/- 2.5 vs 29.9 +/- 2.5, both P < 0.001). CagA seroprevalence was 41% in the 39 infected patients. CagA seropositivity was associated with gastric atrophy/intestinal metaplasia at the antrum (chi(2) = 4.67, P = 0.03) and incisura (chi(2) = 4.88, P = 0.03), but not associated with gastric epithelial apoptosis and Ki-67 expression, nor with antralization at the incisura. CONCLUSIONS: Antralization of gastric incisura is topographically associated with increased gastric epithelial apoptosis and proliferation, but not with CagA seropositivity. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/15482532/Antralization_of_gastric_incisura_is_topographically_associated_with_increased_gastric_epithelial_apoptosis_and_proliferation_but_not_with_CagA_seropositivity_ DB - PRIME DP - Unbound Medicine ER -