Tags

Type your tag names separated by a space and hit enter

Prevalence of hepatitis E virus infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV by blood transfusion.
J Med Virol. 2004 Dec; 74(4):563-72.JM

Abstract

To investigate the prevalence of hepatitis E virus (HEV) infection among patients on maintenance hemodialysis, serum samples collected in January 2003 from 416 patients who had been undergoing hemodialysis for 7.6 +/- 6.3 (mean +/- standard deviation) (range, 0.3-26.0) years in a dialysis unit in Japan and serum samples that had been collected from these patients at the start of hemodialysis were tested for IgG antibodies to HEV (anti-HEV IgG) by an "in-house" enzyme-linked immunosorbent assay (ELISA). Overall, 39 patients (9.4%) had anti-HEV IgG in January 2003, and included 35 patients (8.4%) who had already been positive for anti-HEV IgG at the start of hemodialysis and 4 patients (1%) who seroconverted after initiation of hemodialysis. Periodic serum samples that had been collected from the four seroconverted patients were tested for HEV antibodies and HEV RNA. The four patients became positive for anti-HEV IgG in 1979, 1980, 1988, or 2003, and continued to be seropositive until the end of the observation period. Although anti-HEV IgM was not detectable in the four patients, three were infected transiently with apparently Japanese indigenous HEV strains of genotype 3. The patient who contracted HEV infection in 1979 had been transfused with 2 U of blood 21 days before the transient viremia: one of the two stored pilot serum samples had detectable HEV RNA with 100% identity to that recovered from the patient. Our study provides evidence of transfusion-transmitted HEV infection in Japan in 1979, and that the prevalence of de novo HEV infection during hemodialysis was low (1.1% or 4/374).

Authors+Show Affiliations

Masuko Memorial Hospital and Masuko Institute for Medical Research, Aichi-Ken, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15484278

Citation

Mitsui, Takehiro, et al. "Prevalence of Hepatitis E Virus Infection Among Hemodialysis Patients in Japan: Evidence for Infection With a Genotype 3 HEV By Blood Transfusion." Journal of Medical Virology, vol. 74, no. 4, 2004, pp. 563-72.
Mitsui T, Tsukamoto Y, Yamazaki C, et al. Prevalence of hepatitis E virus infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV by blood transfusion. J Med Virol. 2004;74(4):563-72.
Mitsui, T., Tsukamoto, Y., Yamazaki, C., Masuko, K., Tsuda, F., Takahashi, M., Nishizawa, T., & Okamoto, H. (2004). Prevalence of hepatitis E virus infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV by blood transfusion. Journal of Medical Virology, 74(4), 563-72.
Mitsui T, et al. Prevalence of Hepatitis E Virus Infection Among Hemodialysis Patients in Japan: Evidence for Infection With a Genotype 3 HEV By Blood Transfusion. J Med Virol. 2004;74(4):563-72. PubMed PMID: 15484278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of hepatitis E virus infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV by blood transfusion. AU - Mitsui,Takehiro, AU - Tsukamoto,Yukie, AU - Yamazaki,Chikao, AU - Masuko,Kazuo, AU - Tsuda,Fumio, AU - Takahashi,Masaharu, AU - Nishizawa,Tsutomu, AU - Okamoto,Hiroaki, PY - 2004/10/16/pubmed PY - 2005/1/11/medline PY - 2004/10/16/entrez SP - 563 EP - 72 JF - Journal of medical virology JO - J Med Virol VL - 74 IS - 4 N2 - To investigate the prevalence of hepatitis E virus (HEV) infection among patients on maintenance hemodialysis, serum samples collected in January 2003 from 416 patients who had been undergoing hemodialysis for 7.6 +/- 6.3 (mean +/- standard deviation) (range, 0.3-26.0) years in a dialysis unit in Japan and serum samples that had been collected from these patients at the start of hemodialysis were tested for IgG antibodies to HEV (anti-HEV IgG) by an "in-house" enzyme-linked immunosorbent assay (ELISA). Overall, 39 patients (9.4%) had anti-HEV IgG in January 2003, and included 35 patients (8.4%) who had already been positive for anti-HEV IgG at the start of hemodialysis and 4 patients (1%) who seroconverted after initiation of hemodialysis. Periodic serum samples that had been collected from the four seroconverted patients were tested for HEV antibodies and HEV RNA. The four patients became positive for anti-HEV IgG in 1979, 1980, 1988, or 2003, and continued to be seropositive until the end of the observation period. Although anti-HEV IgM was not detectable in the four patients, three were infected transiently with apparently Japanese indigenous HEV strains of genotype 3. The patient who contracted HEV infection in 1979 had been transfused with 2 U of blood 21 days before the transient viremia: one of the two stored pilot serum samples had detectable HEV RNA with 100% identity to that recovered from the patient. Our study provides evidence of transfusion-transmitted HEV infection in Japan in 1979, and that the prevalence of de novo HEV infection during hemodialysis was low (1.1% or 4/374). SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/15484278/Prevalence_of_hepatitis_E_virus_infection_among_hemodialysis_patients_in_Japan:_evidence_for_infection_with_a_genotype_3_HEV_by_blood_transfusion_ L2 - https://doi.org/10.1002/jmv.20215 DB - PRIME DP - Unbound Medicine ER -